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C5AW45 (C5AW45_METEA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase HAMAP-Rule MF_00260

Short name=PBG HAMAP-Rule MF_00260
EC=2.5.1.61 HAMAP-Rule MF_00260
Alternative name(s):
Hydroxymethylbilane synthase HAMAP-Rule MF_00260
Pre-uroporphyrinogen synthase HAMAP-Rule MF_00260
Gene names
Name:hemC HAMAP-Rule MF_00260 EMBL ACS42908.1
Ordered Locus Names:MexAM1_META1p5307 EMBL ACS42908.1
OrganismMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP] EMBL ACS42908.1
Taxonomic identifier272630 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps By similarity. HAMAP-Rule MF_00260 SAAS SAAS000860

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP-Rule MF_00260 SAAS SAAS000860

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP-Rule MF_00260 SAAS SAAS000860

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. HAMAP-Rule MF_00260 SAAS SAAS000860

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group By similarity. HAMAP-Rule MF_00260

Sequence similarities

Belongs to the HMBS family. HAMAP-Rule MF_00260

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue2291S-(dipyrrolylmethanemethyl)cysteine By similarity HAMAP-Rule MF_00260

Sequences

Sequence LengthMass (Da)Tools
C5AW45 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 0CACDBB3D9D0AFD0

FASTA29430,937
        10         20         30         40         50         60 
MALAQTGMVR DRIVAANPGL ETEIVVVSTV ADRVLDRPLS EIGGKGLFTK ELEQALFADE 

        70         80         90        100        110        120 
IDVAVHSMKD VETWLPDGLA IACILERDDP RDAFLSANGA NGLADLPPGA RVGTSSLRRG 

       130        140        150        160        170        180 
AQVLMHRPDL TIVPLRGNAN TRMRKLEAGE CDATLLALAG LQRLGMADVA RSVLSVEEML 

       190        200        210        220        230        240 
PAVAQGALGI ECRAGDDAIR ALLAPVACAT TTTALDAERG LLAELDGSCR TPIAALAQVK 

       250        260        270        280        290 
GDRISLDGLL FLPDGSRHWA VHREGLAADA DAIGREAGAE LKRAAGDVYF AHLK 

« Hide

References

[1]"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources."
Vuilleumier S., Chistoserdova L., Lee M.C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. expand/collapse author list , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E.
PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14718 / DSM 1338 / AM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001510 Genomic DNA. Translation: ACS42908.1.
RefSeqYP_002966185.1. NC_012808.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272630.MexAM1_META1p5307.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS42908; ACS42908; MexAM1_META1p5307.
GeneID7995074.
KEGGmea:Mex_1p5307.
PATRIC22516259. VBIMetExt101010_5175.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0181.
HOGENOMHOG000228588.
KOK01749.
OMAPLRGNAN.
OrthoDBEOG6HB9Z6.
ProtClustDBCLSK2332407.

Enzyme and pathway databases

BioCycMEXT272630:GBY6-5033-MONOMER.
UniPathwayUPA00251; UER00319.

Family and domain databases

Gene3D3.30.160.40. 1 hit.
HAMAPMF_00260. Porphobil_deam.
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERPTHR11557. PTHR11557. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. SSF54782. 1 hit.
TIGRFAMsTIGR00212. hemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC5AW45_METEA
AccessionPrimary (citable) accession number: C5AW45
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)