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C5AW45

- C5AW45_METEA

UniProt

C5AW45 - C5AW45_METEA

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Protein

Porphobilinogen deaminase

Gene

hemC

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.UniRule annotationSAAS annotation

Catalytic activityi

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3.UniRule annotationSAAS annotation

Cofactori

Binds 1 dipyrromethane group covalently.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. hydroxymethylbilane synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidyl-pyrromethane cofactor linkage Source: InterPro
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-5033-MONOMER.
UniPathwayiUPA00251; UER00319.

Names & Taxonomyi

Protein namesi
Recommended name:
Porphobilinogen deaminaseUniRule annotation (EC:2.5.1.61UniRule annotation)
Short name:
PBGUniRule annotation
Alternative name(s):
Hydroxymethylbilane synthaseUniRule annotation
Pre-uroporphyrinogen synthaseUniRule annotation
Gene namesi
Name:hemCUniRule annotationImported
Ordered Locus Names:MexAM1_META1p5307Imported
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)Imported
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000009081: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei229 – 2291S-(dipyrrolylmethanemethyl)cysteineUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p5307.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMBS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0181.
HOGENOMiHOG000228588.
KOiK01749.
OMAiGAICIES.
OrthoDBiEOG6HB9Z6.

Family and domain databases

Gene3Di3.30.160.40. 1 hit.
HAMAPiMF_00260. Porphobil_deam.
InterProiIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
PANTHERiPTHR11557. PTHR11557. 1 hit.
PfamiPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFiPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSiPR00151. PORPHBDMNASE.
SUPFAMiSSF54782. SSF54782. 1 hit.
TIGRFAMsiTIGR00212. hemC. 1 hit.
PROSITEiPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5AW45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALAQTGMVR DRIVAANPGL ETEIVVVSTV ADRVLDRPLS EIGGKGLFTK
60 70 80 90 100
ELEQALFADE IDVAVHSMKD VETWLPDGLA IACILERDDP RDAFLSANGA
110 120 130 140 150
NGLADLPPGA RVGTSSLRRG AQVLMHRPDL TIVPLRGNAN TRMRKLEAGE
160 170 180 190 200
CDATLLALAG LQRLGMADVA RSVLSVEEML PAVAQGALGI ECRAGDDAIR
210 220 230 240 250
ALLAPVACAT TTTALDAERG LLAELDGSCR TPIAALAQVK GDRISLDGLL
260 270 280 290
FLPDGSRHWA VHREGLAADA DAIGREAGAE LKRAAGDVYF AHLK
Length:294
Mass (Da):30,937
Last modified:July 28, 2009 - v1
Checksum:i0CACDBB3D9D0AFD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001510 Genomic DNA. Translation: ACS42908.1.
RefSeqiYP_002966185.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS42908; ACS42908; MexAM1_META1p5307.
GeneIDi7995074.
KEGGimea:Mex_1p5307.
PATRICi22516259. VBIMetExt101010_5175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001510 Genomic DNA. Translation: ACS42908.1 .
RefSeqi YP_002966185.1. NC_012808.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272630.MexAM1_META1p5307.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS42908 ; ACS42908 ; MexAM1_META1p5307 .
GeneIDi 7995074.
KEGGi mea:Mex_1p5307.
PATRICi 22516259. VBIMetExt101010_5175.

Phylogenomic databases

eggNOGi COG0181.
HOGENOMi HOG000228588.
KOi K01749.
OMAi GAICIES.
OrthoDBi EOG6HB9Z6.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00319 .
BioCyci MEXT272630:GBY6-5033-MONOMER.

Family and domain databases

Gene3Di 3.30.160.40. 1 hit.
HAMAPi MF_00260. Porphobil_deam.
InterProi IPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view ]
PANTHERi PTHR11557. PTHR11557. 1 hit.
Pfami PF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSi PR00151. PORPHBDMNASE.
SUPFAMi SSF54782. SSF54782. 1 hit.
TIGRFAMsi TIGR00212. hemC. 1 hit.
PROSITEi PS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1Imported.

Entry informationi

Entry nameiC5AW45_METEA
AccessioniPrimary (citable) accession number: C5AW45
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethane group.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3