Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

murF

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Alternative name(s):
D-alanyl-D-alanine-adding enzymeUniRule annotation
Gene namesi
Name:murFUniRule annotationImported
Ordered Locus Names:MexAM1_META1p5086Imported
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)Imported
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p5086

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 106Mur_ligaseInterPro annotationAdd BLAST80
Domaini117 – 306Mur_ligase_MInterPro annotationAdd BLAST190
Domaini344 – 409Mur_ligase_CInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the MurCDEF family. MurF subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107EES Bacteria
COG0770 LUCA
HOGENOMiHOG000268120
KOiK01929
OMAiSYNNHWG

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_02019 MurF, 1 hit
InterProiView protein in InterPro
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
IPR035911 MurE/MurF_N
IPR005863 UDP-N-AcMur_synth
PfamiView protein in Pfam
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
SSF63418 SSF63418, 1 hit
TIGRFAMsiTIGR01143 murF, 1 hit

Sequencei

Sequence statusi: Complete.

C5ATZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAPLWTPA ALEAATGGRL IGAPRAVTGA SIDTRSLEPG DLFFAIRGEA
60 70 80 90 100
RDGHDFVRAA LEKGAGAAVV AEARAKEFEG AGPVLAVPGE GDDPVLDAMR
110 120 130 140 150
RLGLAARART GAAIVAVTGS VGKTGTKEAL RHVLSAQGAT HASVASYNNH
160 170 180 190 200
WGVPLTLTRM LEDTRFGVFE IGMNHGAEIL PLTAMVRPDV ALITTVEPVH
210 220 230 240 250
IEHFRSLSAI ADAKGEIFSG LKPGGVAVIN RDNPNYERLL AHAQASRAGR
260 270 280 290 300
VITFGEHAAA DVCAHRILTR PDVSVVDATV MGVPVTYQLG TPGRHVAMNS
310 320 330 340 350
LGVLACIHAL GADLARAALS LASLKPPVGR GERTALRIGD GEAFLVDESY
360 370 380 390 400
NANPASIRAA LSTLAGIDTG AKGRRIAVLG DMKELGAAGE ALHRELADAV
410 420 430 440 450
AANGIDLVFA VGPLMAHLFE ALPMPVRGTA APTAEGVTDA VLATLRSGDA
460 470 480
VMVKGSNSMR MVRIVEAVKA RYAVAPDPRE ASLNAVR
Length:487
Mass (Da):50,405
Last modified:July 28, 2009 - v1
Checksum:i946DA594CB00F681
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001510 Genomic DNA Translation: ACS42690.1
RefSeqiWP_003603656.1, NC_012808.1

Genome annotation databases

EnsemblBacteriaiACS42690; ACS42690; MexAM1_META1p5086
KEGGimea:Mex_1p5086

Similar proteinsi

Entry informationi

Entry nameiC5ATZ1_METEA
AccessioniPrimary (citable) accession number: C5ATZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health