Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C5ATZ1 (C5ATZ1_METEA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136

EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF EMBL ACS42690.1
Ordered Locus Names:MexAM1_META1p5086 EMBL ACS42690.1
OrganismMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1) [Complete proteome] [HAMAP] EMBL ACS42690.1
Taxonomic identifier272630 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
C5ATZ1 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 946DA594CB00F681

FASTA48750,405
        10         20         30         40         50         60 
MSDAPLWTPA ALEAATGGRL IGAPRAVTGA SIDTRSLEPG DLFFAIRGEA RDGHDFVRAA 

        70         80         90        100        110        120 
LEKGAGAAVV AEARAKEFEG AGPVLAVPGE GDDPVLDAMR RLGLAARART GAAIVAVTGS 

       130        140        150        160        170        180 
VGKTGTKEAL RHVLSAQGAT HASVASYNNH WGVPLTLTRM LEDTRFGVFE IGMNHGAEIL 

       190        200        210        220        230        240 
PLTAMVRPDV ALITTVEPVH IEHFRSLSAI ADAKGEIFSG LKPGGVAVIN RDNPNYERLL 

       250        260        270        280        290        300 
AHAQASRAGR VITFGEHAAA DVCAHRILTR PDVSVVDATV MGVPVTYQLG TPGRHVAMNS 

       310        320        330        340        350        360 
LGVLACIHAL GADLARAALS LASLKPPVGR GERTALRIGD GEAFLVDESY NANPASIRAA 

       370        380        390        400        410        420 
LSTLAGIDTG AKGRRIAVLG DMKELGAAGE ALHRELADAV AANGIDLVFA VGPLMAHLFE 

       430        440        450        460        470        480 
ALPMPVRGTA APTAEGVTDA VLATLRSGDA VMVKGSNSMR MVRIVEAVKA RYAVAPDPRE 


ASLNAVR 

« Hide

References

[1]"Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources."
Vuilleumier S., Chistoserdova L., Lee M.C., Bringel F., Lajus A., Zhou Y., Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W., Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E. expand/collapse author list , Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D., Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J., Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C., Lidstrom M.E.
PLoS ONE 4:E5584-E5584(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14718 / DSM 1338 / AM1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001510 Genomic DNA. Translation: ACS42690.1.
RefSeqYP_002965967.1. NC_012808.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272630.MexAM1_META1p5086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS42690; ACS42690; MexAM1_META1p5086.
GeneID7994853.
KEGGmea:Mex_1p5086.
PATRIC22515823. VBIMetExt101010_4960.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268120.
KOK01929.
OMAANHLGEI.
OrthoDBEOG6PKFCR.
ProtClustDBCLSK2332278.

Enzyme and pathway databases

BioCycMEXT272630:GBY6-4812-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5ATZ1_METEA
AccessionPrimary (citable) accession number: C5ATZ1
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)