SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C5ATZ1

- C5ATZ1_METEA

UniProt

C5ATZ1 - C5ATZ1_METEA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Gene
murF, MexAM1_META1p5086
Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activityi

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC
  3. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-4812-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
Gene namesi
Name:murFImported
Ordered Locus Names:MexAM1_META1p5086Imported
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)Imported
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
ProteomesiUP000009081: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p5086.

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0770.
HOGENOMiHOG000268120.
KOiK01929.
OMAiPGNRNNE.
OrthoDBiEOG6PKFCR.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamiPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsiTIGR01143. murF. 1 hit.

Sequencei

Sequence statusi: Complete.

C5ATZ1-1 [UniParc]FASTAAdd to Basket

« Hide

MSDAPLWTPA ALEAATGGRL IGAPRAVTGA SIDTRSLEPG DLFFAIRGEA    50
RDGHDFVRAA LEKGAGAAVV AEARAKEFEG AGPVLAVPGE GDDPVLDAMR 100
RLGLAARART GAAIVAVTGS VGKTGTKEAL RHVLSAQGAT HASVASYNNH 150
WGVPLTLTRM LEDTRFGVFE IGMNHGAEIL PLTAMVRPDV ALITTVEPVH 200
IEHFRSLSAI ADAKGEIFSG LKPGGVAVIN RDNPNYERLL AHAQASRAGR 250
VITFGEHAAA DVCAHRILTR PDVSVVDATV MGVPVTYQLG TPGRHVAMNS 300
LGVLACIHAL GADLARAALS LASLKPPVGR GERTALRIGD GEAFLVDESY 350
NANPASIRAA LSTLAGIDTG AKGRRIAVLG DMKELGAAGE ALHRELADAV 400
AANGIDLVFA VGPLMAHLFE ALPMPVRGTA APTAEGVTDA VLATLRSGDA 450
VMVKGSNSMR MVRIVEAVKA RYAVAPDPRE ASLNAVR 487
Length:487
Mass (Da):50,405
Last modified:July 28, 2009 - v1
Checksum:i946DA594CB00F681
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001510 Genomic DNA. Translation: ACS42690.1.
RefSeqiYP_002965967.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS42690; ACS42690; MexAM1_META1p5086.
GeneIDi7994853.
KEGGimea:Mex_1p5086.
PATRICi22515823. VBIMetExt101010_4960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001510 Genomic DNA. Translation: ACS42690.1 .
RefSeqi YP_002965967.1. NC_012808.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 272630.MexAM1_META1p5086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS42690 ; ACS42690 ; MexAM1_META1p5086 .
GeneIDi 7994853.
KEGGi mea:Mex_1p5086.
PATRICi 22515823. VBIMetExt101010_4960.

Phylogenomic databases

eggNOGi COG0770.
HOGENOMi HOG000268120.
KOi K01929.
OMAi PGNRNNE.
OrthoDBi EOG6PKFCR.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MEXT272630:GBY6-4812-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.10. 1 hit.
3.40.1390.10. 1 hit.
3.90.190.20. 1 hit.
InterProi IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view ]
PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
Pfami PF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view ]
SUPFAMi SSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
SSF63418. SSF63418. 1 hit.
TIGRFAMsi TIGR01143. murF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1.

Entry informationi

Entry nameiC5ATZ1_METEA
AccessioniPrimary (citable) accession number: C5ATZ1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi