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C5ATZ1

- C5ATZ1_METEA

UniProt

C5ATZ1 - C5ATZ1_METEA

Protein

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Gene

murF

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.UniRule annotation
    Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

    Catalytic activityi

    ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Source: InterPro
    3. UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMEXT272630:GBY6-4812-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligaseUniRule annotation (EC:6.3.2.10UniRule annotation)
    Gene namesi
    Name:murFImported
    Ordered Locus Names:MexAM1_META1p5086Imported
    OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)Imported
    Taxonomic identifieri272630 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
    ProteomesiUP000009081: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation
    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Interactioni

    Protein-protein interaction databases

    STRINGi272630.MexAM1_META1p5086.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MurCDEF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0770.
    HOGENOMiHOG000268120.
    KOiK01929.
    OMAiPGNRNNE.
    OrthoDBiEOG6PKFCR.

    Family and domain databases

    Gene3Di3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProiIPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view]
    PANTHERiPTHR23135:SF3. PTHR23135:SF3. 1 hit.
    PfamiPF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsiTIGR01143. murF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5ATZ1-1 [UniParc]FASTAAdd to Basket

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    MSDAPLWTPA ALEAATGGRL IGAPRAVTGA SIDTRSLEPG DLFFAIRGEA    50
    RDGHDFVRAA LEKGAGAAVV AEARAKEFEG AGPVLAVPGE GDDPVLDAMR 100
    RLGLAARART GAAIVAVTGS VGKTGTKEAL RHVLSAQGAT HASVASYNNH 150
    WGVPLTLTRM LEDTRFGVFE IGMNHGAEIL PLTAMVRPDV ALITTVEPVH 200
    IEHFRSLSAI ADAKGEIFSG LKPGGVAVIN RDNPNYERLL AHAQASRAGR 250
    VITFGEHAAA DVCAHRILTR PDVSVVDATV MGVPVTYQLG TPGRHVAMNS 300
    LGVLACIHAL GADLARAALS LASLKPPVGR GERTALRIGD GEAFLVDESY 350
    NANPASIRAA LSTLAGIDTG AKGRRIAVLG DMKELGAAGE ALHRELADAV 400
    AANGIDLVFA VGPLMAHLFE ALPMPVRGTA APTAEGVTDA VLATLRSGDA 450
    VMVKGSNSMR MVRIVEAVKA RYAVAPDPRE ASLNAVR 487
    Length:487
    Mass (Da):50,405
    Last modified:July 28, 2009 - v1
    Checksum:i946DA594CB00F681
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001510 Genomic DNA. Translation: ACS42690.1.
    RefSeqiYP_002965967.1. NC_012808.1.

    Genome annotation databases

    EnsemblBacteriaiACS42690; ACS42690; MexAM1_META1p5086.
    GeneIDi7994853.
    KEGGimea:Mex_1p5086.
    PATRICi22515823. VBIMetExt101010_4960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001510 Genomic DNA. Translation: ACS42690.1 .
    RefSeqi YP_002965967.1. NC_012808.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272630.MexAM1_META1p5086.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS42690 ; ACS42690 ; MexAM1_META1p5086 .
    GeneIDi 7994853.
    KEGGi mea:Mex_1p5086.
    PATRICi 22515823. VBIMetExt101010_4960.

    Phylogenomic databases

    eggNOGi COG0770.
    HOGENOMi HOG000268120.
    KOi K01929.
    OMAi PGNRNNE.
    OrthoDBi EOG6PKFCR.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci MEXT272630:GBY6-4812-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.10. 1 hit.
    3.40.1390.10. 1 hit.
    3.90.190.20. 1 hit.
    InterProi IPR004101. Mur_ligase_C.
    IPR013221. Mur_ligase_cen.
    IPR000713. Mur_ligase_N.
    IPR005863. UDP-N-AcMur-pentapeptide_synth.
    [Graphical view ]
    PANTHERi PTHR23135:SF3. PTHR23135:SF3. 1 hit.
    Pfami PF01225. Mur_ligase. 1 hit.
    PF02875. Mur_ligase_C. 1 hit.
    PF08245. Mur_ligase_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53244. SSF53244. 1 hit.
    SSF53623. SSF53623. 1 hit.
    SSF63418. SSF63418. 1 hit.
    TIGRFAMsi TIGR01143. murF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14718 / DSM 1338 / AM1Imported.

    Entry informationi

    Entry nameiC5ATZ1_METEA
    AccessioniPrimary (citable) accession number: C5ATZ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3