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C5ACE8 (C5ACE8_BURGB) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP-Rule MF_00178
Short name=DMRL synthase HAMAP-Rule MF_00178
Short name=LS HAMAP-Rule MF_00178
Short name=Lumazine synthase HAMAP-Rule MF_00178
EC=2.5.1.78 HAMAP-Rule MF_00178
Gene names
Name:ribH HAMAP-Rule MF_00178
Ordered Locus Names:bglu_1g07930 EMBL ACR27978.1
OrganismBurkholderia glumae (strain BGR1) [Complete proteome] [HAMAP] EMBL ACR27978.1
Taxonomic identifier626418 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia ›

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin By similarity. HAMAP-Rule MF_00178 SAAS SAAS002180

Catalytic activity

1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate. HAMAP-Rule MF_00178 SAAS SAAS002180 RuleBase RU003795

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2. HAMAP-Rule MF_00178 SAAS SAAS002180 RuleBase RU003795

Sequence similarities

Belongs to the DMRL synthase family. HAMAP-Rule MF_00178 RuleBase RU003795

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region58 – 6035-amino-6-(D-ribitylamino)uracil binding By similarity HAMAP-Rule MF_00178
Region82 – 8435-amino-6-(D-ribitylamino)uracil binding By similarity HAMAP-Rule MF_00178
Region87 – 8821-deoxy-L-glycero-tetrulose 4-phosphate binding By similarity HAMAP-Rule MF_00178

Sites

Active site901Proton donor By similarity HAMAP-Rule MF_00178
Binding site2415-amino-6-(D-ribitylamino)uracil By similarity HAMAP-Rule MF_00178
Binding site11515-amino-6-(D-ribitylamino)uracil; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00178
Binding site12911-deoxy-L-glycero-tetrulose 4-phosphate By similarity HAMAP-Rule MF_00178

Sequences

Sequence LengthMass (Da)Tools
C5ACE8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 74FC89EFE2360096

FASTA17018,462
        10         20         30         40         50         60 
MEIGQYQPNL EGEGLRIGIV QSRFNEPVCN GLADACVEEL ERLGVAGEDV LLVTVPGALE 

        70         80         90        100        110        120 
IPLALQKLAE SNQFDALIAL GAVIRGETYH FELVSNESGA GISRIALDFN TPVANAVLTT 

       130        140        150        160        170 
ENDEQAIARM TEKGRDAART AVEMANLTMT LDQLNEDEED EDEDDEEERA

« Hide

References

[1]"Complete genome sequence of Burkholderia glumae BGR1."
Lim J., Lee T.H., Nahm B.H., Choi Y.D., Kim M., Hwang I.
J. Bacteriol. 191:3758-3759(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BGR1 EMBL ACR27978.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001503 Genomic DNA. Translation: ACR27978.1.
RefSeqYP_002910682.1. NC_012724.2.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING626418.bglu_1g07930.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR27978; ACR27978; bglu_1g07930.
GeneID7907244.
KEGGbgl:bglu_1g07930.
PATRIC19108920. VBIBurGlu130723_3551.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0054.
HOGENOMHOG000229250.
KOK00794.
OMATALEMVS.
ProtClustDBPRK00061.

Enzyme and pathway databases

BioCycBGLU626418:GJI5-812-MONOMER.
UniPathwayUPA00275; UER00404.

Family and domain databases

Gene3D3.40.50.960. 1 hit.
HAMAPMF_00178. Lumazine_synth.
InterProIPR002180. DMRL_synthase.
[Graphical view]
PANTHERPTHR21058. PTHR21058. 1 hit.
PfamPF00885. DMRL_synthase. 1 hit.
[Graphical view]
SUPFAMSSF52121. DMRL_synthase. 1 hit.
TIGRFAMsTIGR00114. lumazine-synth. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC5ACE8_BURGB
AccessionPrimary (citable) accession number: C5ACE8
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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