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C5AA24

- C5AA24_BURGB

UniProt

C5AA24 - C5AA24_BURGB

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Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Burkholderia glumae (strain BGR1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Coenzyme AUniRule annotation
Binding sitei512 – 5121ATPUniRule annotation
Binding sitei528 – 5281ATPUniRule annotation
Binding sitei536 – 5361Coenzyme A; via carbonyl oxygenUniRule annotation
Binding sitei539 – 5391ATPUniRule annotation
Metal bindingi550 – 5501Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi552 – 5521Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi555 – 5551Magnesium; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi397 – 3993ATPUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGLU626418:GJI5-2579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:bglu_1g25360Imported
OrganismiBurkholderia glumae (strain BGR1)Imported
Taxonomic identifieri626418 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000002187: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251N6-acetyllysineUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi626418.bglu_1g25360.

Structurei

3D structure databases

ProteinModelPortaliC5AA24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni197 – 2004Coenzyme A bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiAWIWYRD.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5AA24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAIESVLHE RRQFAPPASV EQAANISGMD AYRALVDEAG RDYEGFWARL
60 70 80 90 100
ARESLDWHKP FSSVLDESNA PFYKWFEDGE LNASYNCLDR HVAAGRGERV
110 120 130 140 150
AVIFEADDGT VTRVTYAELL ARVCRLANAL KARGIGRGDR VIIYIPMSIE
160 170 180 190 200
GIVAMQACAR IGATHSVVFG GFSAKSLNER LVDVGACALI TADEQVRGGK
210 220 230 240 250
TLPIKSIADD AIAMGGCEAV KSVIVYRRTG GEVAWHEGRD LWLDEITANQ
260 270 280 290 300
PDTCEPEWVG AEHPLFILYT SGSTGKPKGL QHSTGGYLLW AALTMDWTFD
310 320 330 340 350
RKPDDVFWCT ADIGWITGHT YITYGPLATC STQVVFEGVP TYPNAGRFWK
360 370 380 390 400
MVADHKVTVF YTAPTAIRSL IKASGADEAA HPSRYDLSSL RIIGTVGEPI
410 420 430 440 450
NPESWMWYHK NVGGERCPIV DTWFQTETGG HMITPLPGAT PTVPGSCTLG
460 470 480 490 500
LPGIMAAVVD ETGQDVPNGQ GGILVIKRPW PAMARTIWGD PDRFRKSYFP
510 520 530 540 550
DELGGRLYLA GDGTVRDKDT GYFTIMGRID DVLNVSGHRL GTMEIESALV
560 570 580 590 600
SHELVAEAAV VGRPDDMTGE AVVAFVVLKR TRPEGEEAQQ IAKMLRDWVG
610 620 630 640 650
KEIGPIAKPK DIRFGDNLPK TRSGKIMRRL LRSLAKGEAV TQDTSTLENP
660
AILEQLAEAR
Length:660
Mass (Da):72,189
Last modified:July 28, 2009 - v1
Checksum:i2C43F2FA5C9CF54C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001503 Genomic DNA. Translation: ACR29612.1.
RefSeqiWP_015876482.1. NC_012724.2.
YP_002912316.1. NC_012724.2.

Genome annotation databases

EnsemblBacteriaiACR29612; ACR29612; bglu_1g25360.
GeneIDi7906710.
KEGGibgl:bglu_1g25360.
PATRICi19112782. VBIBurGlu130723_5450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001503 Genomic DNA. Translation: ACR29612.1 .
RefSeqi WP_015876482.1. NC_012724.2.
YP_002912316.1. NC_012724.2.

3D structure databases

ProteinModelPortali C5AA24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 626418.bglu_1g25360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR29612 ; ACR29612 ; bglu_1g25360 .
GeneIDi 7906710.
KEGGi bgl:bglu_1g25360.
PATRICi 19112782. VBIBurGlu130723_5450.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi AWIWYRD.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci BGLU626418:GJI5-2579-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Burkholderia glumae BGR1."
    Lim J., Lee T.-H., Nahm B.H., Choi Y.D., Kim M., Hwang I.
    J. Bacteriol. 191:3758-3759(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BGR1Imported.

Entry informationi

Entry nameiC5AA24_BURGB
AccessioniPrimary (citable) accession number: C5AA24
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3