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C5AA24

- C5AA24_BURGB

UniProt

C5AA24 - C5AA24_BURGB

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Protein
Acetyl-coenzyme A synthetase
Gene
acsA, bglu_1g25360
Organism
Burkholderia glumae (strain BGR1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Coenzyme A By similarityUniRule annotation
Binding sitei397 – 3971Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei512 – 5121Substrate By similarityUniRule annotation
Binding sitei528 – 5281Substrate By similarityUniRule annotation
Active sitei530 – 5301 By similarityUniRule annotation
Binding sitei536 – 5361Coenzyme A By similarityUniRule annotation
Binding sitei539 – 5391Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi552 – 5521Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei600 – 6001Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGLU626418:GJI5-2579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:bglu_1g25360Imported
OrganismiBurkholderia glumae (strain BGR1)Imported
Taxonomic identifieri626418 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000002187: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi626418.bglu_1g25360.

Structurei

3D structure databases

ProteinModelPortaliC5AA24.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiAWIWYRD.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5AA24-1 [UniParc]FASTAAdd to Basket

« Hide

MSAIESVLHE RRQFAPPASV EQAANISGMD AYRALVDEAG RDYEGFWARL    50
ARESLDWHKP FSSVLDESNA PFYKWFEDGE LNASYNCLDR HVAAGRGERV 100
AVIFEADDGT VTRVTYAELL ARVCRLANAL KARGIGRGDR VIIYIPMSIE 150
GIVAMQACAR IGATHSVVFG GFSAKSLNER LVDVGACALI TADEQVRGGK 200
TLPIKSIADD AIAMGGCEAV KSVIVYRRTG GEVAWHEGRD LWLDEITANQ 250
PDTCEPEWVG AEHPLFILYT SGSTGKPKGL QHSTGGYLLW AALTMDWTFD 300
RKPDDVFWCT ADIGWITGHT YITYGPLATC STQVVFEGVP TYPNAGRFWK 350
MVADHKVTVF YTAPTAIRSL IKASGADEAA HPSRYDLSSL RIIGTVGEPI 400
NPESWMWYHK NVGGERCPIV DTWFQTETGG HMITPLPGAT PTVPGSCTLG 450
LPGIMAAVVD ETGQDVPNGQ GGILVIKRPW PAMARTIWGD PDRFRKSYFP 500
DELGGRLYLA GDGTVRDKDT GYFTIMGRID DVLNVSGHRL GTMEIESALV 550
SHELVAEAAV VGRPDDMTGE AVVAFVVLKR TRPEGEEAQQ IAKMLRDWVG 600
KEIGPIAKPK DIRFGDNLPK TRSGKIMRRL LRSLAKGEAV TQDTSTLENP 650
AILEQLAEAR 660
Length:660
Mass (Da):72,189
Last modified:July 28, 2009 - v1
Checksum:i2C43F2FA5C9CF54C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001503 Genomic DNA. Translation: ACR29612.1.
RefSeqiWP_015876482.1. NC_012724.2.
YP_002912316.1. NC_012724.2.

Genome annotation databases

EnsemblBacteriaiACR29612; ACR29612; bglu_1g25360.
GeneIDi7906710.
KEGGibgl:bglu_1g25360.
PATRICi19112782. VBIBurGlu130723_5450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001503 Genomic DNA. Translation: ACR29612.1 .
RefSeqi WP_015876482.1. NC_012724.2.
YP_002912316.1. NC_012724.2.

3D structure databases

ProteinModelPortali C5AA24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 626418.bglu_1g25360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR29612 ; ACR29612 ; bglu_1g25360 .
GeneIDi 7906710.
KEGGi bgl:bglu_1g25360.
PATRICi 19112782. VBIBurGlu130723_5450.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi AWIWYRD.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci BGLU626418:GJI5-2579-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Burkholderia glumae BGR1."
    Lim J., Lee T.H., Nahm B.H., Choi Y.D., Kim M., Hwang I.
    J. Bacteriol. 191:3758-3759(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BGR1Imported.

Entry informationi

Entry nameiC5AA24_BURGB
AccessioniPrimary (citable) accession number: C5AA24
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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