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C5A7J1

- GCSPA_THEGJ

UniProt

C5A7J1 - GCSPA_THEGJ

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciTGAM593117:GHFT-1732-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TGAM_1701
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000001488: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000212670Add
BLAST

Proteomic databases

PaxDbiC5A7J1.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1701.

Structurei

3D structure databases

ProteinModelPortaliC5A7J1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiGLEVANC.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C5A7J1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKHYLPNLA HREEMLREIG FASIDELFSD VPEGMLKEFN LPGGKSEYEV
60 70 80 90 100
FIELNETLSK NKTALEMPSF LGAGTYFHYI PAHVKYLIER SEFLTAYTPY
110 120 130 140 150
QPEISQGMLQ ALFEYQSMMA ELYGLPVVNS SMYDWGTSIA EAALMTVRLH
160 170 180 190 200
RGKRKRFVIP KAISPEKKAV IETYTRGANL EIVEVPWDES GRLDIEKLKE
210 220 230 240 250
AVEDSAGVYV EMANFFGLVE ENVREIGEIA HEAGAYFVVG ADPTMLGIFE
260 270 280 290 300
APGELGADIA VGEASYLGNP MNFGGPRAGV FAVRNDKKLI RQMPGRIIGM
310 320 330 340 350
TRDAEGKRAF VMTLQTREQH IRRAKATSNI CSNEALVAVA SAIHLATLGP
360 370 380 390 400
KGLRELGEVI LKNTAYLKKR LSEVAEIPFE GLYFKDVPVK FKRPYGEIHE
410 420 430 440
ALLAKGIHGG YYIGKHFPEL GETALFAATE TTRKEWVHAL IEALKEVA
Length:448
Mass (Da):49,888
Last modified:July 28, 2009 - v1
Checksum:i2003338C2380E378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS34203.1.
RefSeqiYP_002960067.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS34203; ACS34203; TGAM_1701.
GeneIDi7987420.
KEGGitga:TGAM_1701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS34203.1 .
RefSeqi YP_002960067.1. NC_012804.1.

3D structure databases

ProteinModelPortali C5A7J1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 593117.TGAM_1701.

Proteomic databases

PaxDbi C5A7J1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS34203 ; ACS34203 ; TGAM_1701 .
GeneIDi 7987420.
KEGGi tga:TGAM_1701.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi GLEVANC.

Enzyme and pathway databases

BioCyci TGAM593117:GHFT-1732-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
    Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
    Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15229 / JCM 11827 / EJ3.

Entry informationi

Entry nameiGCSPA_THEGJ
AccessioniPrimary (citable) accession number: C5A7J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3