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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1768-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TGAM_1701
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126701 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PaxDbiC5A7J1
PRIDEiC5A7J1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1701

Structurei

3D structure databases

ProteinModelPortaliC5A7J1
SMRiC5A7J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C5A7J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKHYLPNLA HREEMLREIG FASIDELFSD VPEGMLKEFN LPGGKSEYEV
60 70 80 90 100
FIELNETLSK NKTALEMPSF LGAGTYFHYI PAHVKYLIER SEFLTAYTPY
110 120 130 140 150
QPEISQGMLQ ALFEYQSMMA ELYGLPVVNS SMYDWGTSIA EAALMTVRLH
160 170 180 190 200
RGKRKRFVIP KAISPEKKAV IETYTRGANL EIVEVPWDES GRLDIEKLKE
210 220 230 240 250
AVEDSAGVYV EMANFFGLVE ENVREIGEIA HEAGAYFVVG ADPTMLGIFE
260 270 280 290 300
APGELGADIA VGEASYLGNP MNFGGPRAGV FAVRNDKKLI RQMPGRIIGM
310 320 330 340 350
TRDAEGKRAF VMTLQTREQH IRRAKATSNI CSNEALVAVA SAIHLATLGP
360 370 380 390 400
KGLRELGEVI LKNTAYLKKR LSEVAEIPFE GLYFKDVPVK FKRPYGEIHE
410 420 430 440
ALLAKGIHGG YYIGKHFPEL GETALFAATE TTRKEWVHAL IEALKEVA
Length:448
Mass (Da):49,888
Last modified:July 28, 2009 - v1
Checksum:i2003338C2380E378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS34203.1
RefSeqiWP_015859313.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS34203; ACS34203; TGAM_1701
GeneIDi7987420
KEGGitga:TGAM_1701
PATRICifig|593117.10.peg.1708

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THEGJ
AccessioniPrimary (citable) accession number: C5A7J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health