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C5A7J0

- GCSPB_THEGJ

UniProt

C5A7J0 - GCSPB_THEGJ

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, TGAM_1700
Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTGAM593117:GHFT-1731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:TGAM_1700
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000001488: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000212679Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei273 – 2731N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PaxDbiC5A7J0.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi593117.TGAM_1700.

Structurei

3D structure databases

ProteinModelPortaliC5A7J0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiLGETPWD.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C5A7J0-1 [UniParc]FASTAAdd to Basket

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MFRQAKWDEP LIFELSREGR VGYTLPKPIE DLEVEIPEKI RRKSKLDLPE    50
LSEPEIVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE EMAAHPGVAY 100
IHPYQDERTV QGALKIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVSI 150
IRTYHIDNGE PQRDEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTVDL 200
EALENAVGER TAGLMLTNPN TLGIFEDEIL EIAKIVHKAG GLLYYDGANL 250
NAVLGKVRPG DMGFDIVHLN LHKTFSTPHG GGGPGSGPVG VKDFLKDYLP 300
VPLVGYDEEN DRYYLDYNVP KSIGKVKELY GNFAVMVRAL VYLKVMGRDG 350
LKNASEIAVL NANYLTRKLL GTRGYELPGK KLRKHETVFS AEPMKKETGV 400
TAMDVAKRLL DFGMHAPTVY FPLIVHEALM IEPTETVSKE ELDAYVEALK 450
RISDEAYTNP EVVKSAPHNT AVRRVDDVMA VKKPVISWRM YLELKEKGEI 500
NY 502
Length:502
Mass (Da):56,100
Last modified:July 28, 2009 - v1
Checksum:iAFA1836BFAA7BF8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS34202.1.
RefSeqiWP_015859312.1. NC_012804.1.
YP_002960066.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS34202; ACS34202; TGAM_1700.
GeneIDi7987419.
KEGGitga:TGAM_1700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS34202.1 .
RefSeqi WP_015859312.1. NC_012804.1.
YP_002960066.1. NC_012804.1.

3D structure databases

ProteinModelPortali C5A7J0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 593117.TGAM_1700.

Proteomic databases

PaxDbi C5A7J0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS34202 ; ACS34202 ; TGAM_1700 .
GeneIDi 7987419.
KEGGi tga:TGAM_1700.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi LGETPWD.

Enzyme and pathway databases

BioCyci TGAM593117:GHFT-1731-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
    Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
    Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15229 / JCM 11827 / EJ3.

Entry informationi

Entry nameiGCSPB_THEGJ
AccessioniPrimary (citable) accession number: C5A7J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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