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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1767-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:TGAM_1700
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126791 – 502Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiC5A7J0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1700

Structurei

3D structure databases

ProteinModelPortaliC5A7J0
SMRiC5A7J0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00076 Archaea
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG093Z01WJ

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C5A7J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRQAKWDEP LIFELSREGR VGYTLPKPIE DLEVEIPEKI RRKSKLDLPE
60 70 80 90 100
LSEPEIVKHY TRLSEMNYGV DSGIYPLGSC TMKYNPKINE EMAAHPGVAY
110 120 130 140 150
IHPYQDERTV QGALKIMWEL EQWLKEITGM DRFTLQPAAG ANGEFTGVSI
160 170 180 190 200
IRTYHIDNGE PQRDEMLVPD SAHGTNPASA AMAGFKVIEI PSNENGTVDL
210 220 230 240 250
EALENAVGER TAGLMLTNPN TLGIFEDEIL EIAKIVHKAG GLLYYDGANL
260 270 280 290 300
NAVLGKVRPG DMGFDIVHLN LHKTFSTPHG GGGPGSGPVG VKDFLKDYLP
310 320 330 340 350
VPLVGYDEEN DRYYLDYNVP KSIGKVKELY GNFAVMVRAL VYLKVMGRDG
360 370 380 390 400
LKNASEIAVL NANYLTRKLL GTRGYELPGK KLRKHETVFS AEPMKKETGV
410 420 430 440 450
TAMDVAKRLL DFGMHAPTVY FPLIVHEALM IEPTETVSKE ELDAYVEALK
460 470 480 490 500
RISDEAYTNP EVVKSAPHNT AVRRVDDVMA VKKPVISWRM YLELKEKGEI

NY
Length:502
Mass (Da):56,100
Last modified:July 28, 2009 - v1
Checksum:iAFA1836BFAA7BF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS34202.1
RefSeqiWP_015859312.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS34202; ACS34202; TGAM_1700
GeneIDi7987419
KEGGitga:TGAM_1700
PATRICifig|593117.10.peg.1707

Similar proteinsi

Entry informationi

Entry nameiGCSPB_THEGJ
AccessioniPrimary (citable) accession number: C5A7J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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