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Protein

Ribonuclease Z

Gene

rnz

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc 1; catalyticUniRule annotation1
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Active sitei65Proton acceptorUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi137Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 2; catalyticUniRule annotation1
Metal bindingi263Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1114-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:TGAM_1082
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002160201 – 314Ribonuclease ZAdd BLAST314

Proteomic databases

PaxDbiC5A5S2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1082

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501 Archaea
COG1234 LUCA
HOGENOMiHOG000272419
KOiK00784
OMAiGTQRQMM
OrthoDBiPOG093Z04VY

Family and domain databases

CDDicd07717 RNaseZ_ZiPD-like_MBL-fold, 1 hit
Gene3Di3.60.15.10, 1 hit
HAMAPiMF_01818 RNase_Z_BN, 1 hit
InterProiView protein in InterPro
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
IPR013471 RNase_Z/BN
PfamiView protein in Pfam
PF00753 Lactamase_B, 1 hit
PF12706 Lactamase_B_2, 1 hit
SMARTiView protein in SMART
SM00849 Lactamase_B, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
TIGRFAMsiTIGR02651 RNase_Z, 1 hit

Sequencei

Sequence statusi: Complete.

C5A5S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQVIFLGSG GIMPTRERNV PAIALRYKGE IILFDVGEGT IRQMNSAKLS
60 70 80 90 100
PMRVEKIFIT HFHGDHYLGL GGLIQTMNLW NREKPLHIYG PKYTFEFVQN
110 120 130 140 150
FLNSGFFRPG FEVHVHELGE TRLKFKDYEI WSFKVEHGIP ALGYVFKEKD
160 170 180 190 200
KRGKFLPEKL AQYGLRPGPI LGKLEKDGKI EWNGQVIRLE DVTGPRRRGV
210 220 230 240 250
KVVYTGDTEP CERVRLFAER ADLLIHDATY LSDGDRGDSY HSTVEEACET
260 270 280 290 300
ARRAKVKLLA LFHRAFRYTY DEYLSGASKI CQETGVNFVI PRDFDVLTYK
310
SGEWKRENLL EEGK
Length:314
Mass (Da):36,171
Last modified:July 28, 2009 - v1
Checksum:iE0484B5C5C2719F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS33584.1
RefSeqiWP_015858697.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS33584; ACS33584; TGAM_1082
GeneIDi7986956
KEGGitga:TGAM_1082
PATRICifig|593117.10.peg.1081

Similar proteinsi

Entry informationi

Entry nameiRNZ_THEGJ
AccessioniPrimary (citable) accession number: C5A5S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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