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Protein

Ribonuclease Z

Gene

rnz

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Zinc 1; catalyticUniRule annotation1
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Active sitei65Proton acceptorUniRule annotation1
Metal bindingi65Zinc 2; catalyticUniRule annotation1
Metal bindingi66Zinc 2; catalyticUniRule annotation1
Metal bindingi137Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 1; catalyticUniRule annotation1
Metal bindingi207Zinc 2; catalyticUniRule annotation1
Metal bindingi263Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:TGAM_1082
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002160201 – 314Ribonuclease ZAdd BLAST314

Proteomic databases

PaxDbiC5A5S2.
PRIDEiC5A5S2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1082.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

C5A5S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQVIFLGSG GIMPTRERNV PAIALRYKGE IILFDVGEGT IRQMNSAKLS
60 70 80 90 100
PMRVEKIFIT HFHGDHYLGL GGLIQTMNLW NREKPLHIYG PKYTFEFVQN
110 120 130 140 150
FLNSGFFRPG FEVHVHELGE TRLKFKDYEI WSFKVEHGIP ALGYVFKEKD
160 170 180 190 200
KRGKFLPEKL AQYGLRPGPI LGKLEKDGKI EWNGQVIRLE DVTGPRRRGV
210 220 230 240 250
KVVYTGDTEP CERVRLFAER ADLLIHDATY LSDGDRGDSY HSTVEEACET
260 270 280 290 300
ARRAKVKLLA LFHRAFRYTY DEYLSGASKI CQETGVNFVI PRDFDVLTYK
310
SGEWKRENLL EEGK
Length:314
Mass (Da):36,171
Last modified:July 28, 2009 - v1
Checksum:iE0484B5C5C2719F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA. Translation: ACS33584.1.
RefSeqiWP_015858697.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS33584; ACS33584; TGAM_1082.
GeneIDi7986956.
KEGGitga:TGAM_1082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA. Translation: ACS33584.1.
RefSeqiWP_015858697.1. NC_012804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi593117.TGAM_1082.

Proteomic databases

PaxDbiC5A5S2.
PRIDEiC5A5S2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS33584; ACS33584; TGAM_1082.
GeneIDi7986956.
KEGGitga:TGAM_1082.

Phylogenomic databases

eggNOGiarCOG00501. Archaea.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNZ_THEGJ
AccessioniPrimary (citable) accession number: C5A5S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.