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Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgiA)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88IronUniRule annotation1
Metal bindingi90IronUniRule annotation1
Metal bindingi97IronUniRule annotation1
Metal bindingi136IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1110-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiAUniRule annotation
Ordered Locus Names:TGAM_1078
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002152211 – 189Glucose-6-phosphate isomeraseAdd BLAST189

Proteomic databases

PaxDbiC5A5R8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1078

Structurei

3D structure databases

ProteinModelPortaliC5A5R8
SMRiC5A5R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal-type GPI family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02602 Archaea
COG2140 LUCA
HOGENOMiHOG000243903
KOiK06859
OMAiYPADAGH
OrthoDBiPOG093Z0BUP

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_01410 G6P_isomerase_arch, 1 hit
InterProiView protein in InterPro
IPR016758 G6P_isomerase_archaea/bacteria
IPR010551 G6P_isomerase_prok
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF06560 GPI, 1 hit
PIRSFiPIRSF019325 Glucose-6-phosphate_isomerase, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

C5A5R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYKRPFGVK IDLETGVIPG AKRIVRKLSD MRGYFVDEEA YEKLLREDPV
60 70 80 90 100
VYEVYAIEQE EREGDLNFAT TVLYPGKVGK EFFFTKGHYH AKADRAEIYY
110 120 130 140 150
ALKGKGGMLL QTPEGEAEWI PMEPGTVVYV PPYWAHRTVN TGGEPFVFLA
160 170 180
IYPADAGHDY GSIKEKGFSK IVIDEGGEVK IVDNPRWSV
Length:189
Mass (Da):21,433
Last modified:July 28, 2009 - v1
Checksum:i1640DB8BE08DA244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS33580.1
RefSeqiWP_015858693.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS33580; ACS33580; TGAM_1078
GeneIDi7986952
KEGGitga:TGAM_1078
PATRICifig|593117.10.peg.1077

Similar proteinsi

Entry informationi

Entry nameiGPI_THEGJ
AccessioniPrimary (citable) accession number: C5A5R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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