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C5A5R8

- GPI_THEGJ

UniProt

C5A5R8 - GPI_THEGJ

Protein

Glucose-6-phosphate isomerase

Gene

pgiA

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi88 – 881IronUniRule annotation
    Metal bindingi90 – 901IronUniRule annotation
    Metal bindingi97 – 971IronUniRule annotation
    Metal bindingi136 – 1361IronUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: InterPro

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciTGAM593117:GHFT-1102-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiAUniRule annotation
    Ordered Locus Names:TGAM_1078
    OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
    Taxonomic identifieri593117 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000001488: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 189189Glucose-6-phosphate isomerasePRO_1000215221Add
    BLAST

    Proteomic databases

    PaxDbiC5A5R8.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi593117.TGAM_1078.

    Structurei

    3D structure databases

    ProteinModelPortaliC5A5R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal-type GPI family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2140.
    HOGENOMiHOG000243903.
    KOiK06859.
    OMAiYPADAGH.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_01410. G6P_isomerase_arch.
    InterProiIPR010551. G6P_isomerase_prok.
    IPR016758. G6P_isomerase_subgr.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF06560. GPI. 1 hit.
    [Graphical view]
    PIRSFiPIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5A5R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYKRPFGVK IDLETGVIPG AKRIVRKLSD MRGYFVDEEA YEKLLREDPV    50
    VYEVYAIEQE EREGDLNFAT TVLYPGKVGK EFFFTKGHYH AKADRAEIYY 100
    ALKGKGGMLL QTPEGEAEWI PMEPGTVVYV PPYWAHRTVN TGGEPFVFLA 150
    IYPADAGHDY GSIKEKGFSK IVIDEGGEVK IVDNPRWSV 189
    Length:189
    Mass (Da):21,433
    Last modified:July 28, 2009 - v1
    Checksum:i1640DB8BE08DA244
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33580.1.
    RefSeqiWP_015858693.1. NC_012804.1.
    YP_002959444.1. NC_012804.1.

    Genome annotation databases

    EnsemblBacteriaiACS33580; ACS33580; TGAM_1078.
    GeneIDi7986952.
    KEGGitga:TGAM_1078.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33580.1 .
    RefSeqi WP_015858693.1. NC_012804.1.
    YP_002959444.1. NC_012804.1.

    3D structure databases

    ProteinModelPortali C5A5R8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 593117.TGAM_1078.

    Proteomic databases

    PaxDbi C5A5R8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS33580 ; ACS33580 ; TGAM_1078 .
    GeneIDi 7986952.
    KEGGi tga:TGAM_1078.

    Phylogenomic databases

    eggNOGi COG2140.
    HOGENOMi HOG000243903.
    KOi K06859.
    OMAi YPADAGH.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci TGAM593117:GHFT-1102-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_01410. G6P_isomerase_arch.
    InterProi IPR010551. G6P_isomerase_prok.
    IPR016758. G6P_isomerase_subgr.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF06560. GPI. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF019325. Glucose-6-phosphate_isomerase. 1 hit.
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
      Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
      Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15229 / JCM 11827 / EJ3.

    Entry informationi

    Entry nameiGPI_THEGJ
    AccessioniPrimary (citable) accession number: C5A5R8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3