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C5A5P1

- C5A5P1_THEGJ

UniProt

C5A5P1 - C5A5P1_THEGJ

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Protein

Proline--tRNA ligase

Gene
proS, TGAM_1051
Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) By similarity.UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. proline-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. prolyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTGAM593117:GHFT-1074-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetase
Gene namesi
Name:proSUniRule annotationImported
Ordered Locus Names:TGAM_1051Imported
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)Imported
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000001488: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiC5A5P1.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1051.

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension By similarity.UniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0442.
HOGENOMiHOG000167538.
KOiK01881.
OMAiNDWEIKG.

Family and domain databases

Gene3Di3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view]
PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PRINTSiPR01046. TRNASYNTHPRO.
SMARTiSM00946. ProRS-C_1. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5A5P1-1 [UniParc]FASTAAdd to Basket

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MAKVKREKWS NEFSEWYNEL LETAGIIDKR YPVKGMNVWL PYGLKIMRNI    50
EKFIHSEMAR TGHEEVLFPA LIPETEFQKE AEHIKGFEDE VYWVTHAGLD 100
PLDVRLILRP TSETAMYSMF SLWIRSHADL PFKVYQIVNV YRYETKHTRP 150
LIRVREISRF FEAHTAHVDF EDAERQIKED LEIFDRLAKF LALPYVISRR 200
PDWDKFPGAF YSLGAEIMMP DGRTLQIGTM HNYKQNFAKA YNIQYETETG 250
DHEYVHQTTF GMSERLLAAV IAVHGDDSGM VLPPTIAPIQ VVIVPIPKKD 300
ANVDVFAYAR EIAEELGKAG FRVHVDERDI RPGRKYYDWE LKGVPLRIEV 350
GPRDVEGRKA VLARRDTFEK VTVERDAIVE EVKKTLDAIH ENLYQRAKEF 400
LESHIKRVDT IEEAKAVFED RRGIVEIPWC GDEECGLKME EELDAKMLGT 450
PYPEEKAREG IEGKKCPVCG REAKFIARFA RTY 483
Length:483
Mass (Da):56,181
Last modified:July 28, 2009 - v1
Checksum:i89A3DA57FD926675
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS33553.1.
RefSeqiYP_002959417.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS33553; ACS33553; TGAM_1051.
GeneIDi7986925.
KEGGitga:TGAM_1051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001398 Genomic DNA. Translation: ACS33553.1 .
RefSeqi YP_002959417.1. NC_012804.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 593117.TGAM_1051.

Proteomic databases

PaxDbi C5A5P1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS33553 ; ACS33553 ; TGAM_1051 .
GeneIDi 7986925.
KEGGi tga:TGAM_1051.

Phylogenomic databases

eggNOGi COG0442.
HOGENOMi HOG000167538.
KOi K01881.
OMAi NDWEIKG.

Enzyme and pathway databases

BioCyci TGAM593117:GHFT-1074-MONOMER.

Family and domain databases

Gene3Di 3.30.110.30. 1 hit.
3.40.50.800. 1 hit.
HAMAPi MF_01571. Pro_tRNA_synth_type3.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR002316. Pro-tRNA-ligase_IIa.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
[Graphical view ]
PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
Pfami PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view ]
PRINTSi PR01046. TRNASYNTHPRO.
SMARTi SM00946. ProRS-C_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
    Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
    Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15229 / JCM 11827 / EJ3.

Entry informationi

Entry nameiC5A5P1_THEGJ
AccessioniPrimary (citable) accession number: C5A5P1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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