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C5A5P1

- C5A5P1_THEGJ

UniProt

C5A5P1 - C5A5P1_THEGJ

Protein

Proline--tRNA ligase

Gene

proS

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

    Catalytic activityi

    ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proline-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prolyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTGAM593117:GHFT-1074-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
    Alternative name(s):
    Prolyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:proSUniRule annotationImported
    Ordered Locus Names:TGAM_1051Imported
    OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)Imported
    Taxonomic identifieri593117 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000001488: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    PTM / Processingi

    Proteomic databases

    PaxDbiC5A5P1.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi593117.TGAM_1051.

    Family & Domainsi

    Domaini

    Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0442.
    HOGENOMiHOG000167538.
    KOiK01881.
    OMAiNDWEIKG.

    Family and domain databases

    Gene3Di3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_01571. Pro_tRNA_synth_type3.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view]
    PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01046. TRNASYNTHPRO.
    SMARTiSM00946. ProRS-C_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C5A5P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVKREKWS NEFSEWYNEL LETAGIIDKR YPVKGMNVWL PYGLKIMRNI    50
    EKFIHSEMAR TGHEEVLFPA LIPETEFQKE AEHIKGFEDE VYWVTHAGLD 100
    PLDVRLILRP TSETAMYSMF SLWIRSHADL PFKVYQIVNV YRYETKHTRP 150
    LIRVREISRF FEAHTAHVDF EDAERQIKED LEIFDRLAKF LALPYVISRR 200
    PDWDKFPGAF YSLGAEIMMP DGRTLQIGTM HNYKQNFAKA YNIQYETETG 250
    DHEYVHQTTF GMSERLLAAV IAVHGDDSGM VLPPTIAPIQ VVIVPIPKKD 300
    ANVDVFAYAR EIAEELGKAG FRVHVDERDI RPGRKYYDWE LKGVPLRIEV 350
    GPRDVEGRKA VLARRDTFEK VTVERDAIVE EVKKTLDAIH ENLYQRAKEF 400
    LESHIKRVDT IEEAKAVFED RRGIVEIPWC GDEECGLKME EELDAKMLGT 450
    PYPEEKAREG IEGKKCPVCG REAKFIARFA RTY 483
    Length:483
    Mass (Da):56,181
    Last modified:July 28, 2009 - v1
    Checksum:i89A3DA57FD926675
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33553.1.
    RefSeqiYP_002959417.1. NC_012804.1.

    Genome annotation databases

    EnsemblBacteriaiACS33553; ACS33553; TGAM_1051.
    GeneIDi7986925.
    KEGGitga:TGAM_1051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33553.1 .
    RefSeqi YP_002959417.1. NC_012804.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 593117.TGAM_1051.

    Proteomic databases

    PaxDbi C5A5P1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS33553 ; ACS33553 ; TGAM_1051 .
    GeneIDi 7986925.
    KEGGi tga:TGAM_1051.

    Phylogenomic databases

    eggNOGi COG0442.
    HOGENOMi HOG000167538.
    KOi K01881.
    OMAi NDWEIKG.

    Enzyme and pathway databases

    BioCyci TGAM593117:GHFT-1074-MONOMER.

    Family and domain databases

    Gene3Di 3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_01571. Pro_tRNA_synth_type3.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view ]
    PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01046. TRNASYNTHPRO.
    SMARTi SM00946. ProRS-C_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
      Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
      Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15229 / JCM 11827 / EJ3Imported.

    Entry informationi

    Entry nameiC5A5P1_THEGJ
    AccessioniPrimary (citable) accession number: C5A5P1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3