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Protein

Proline--tRNA ligase

Gene

proS

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1083-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotationImported
Ordered Locus Names:TGAM_1051Imported
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)Imported
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiC5A5P1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1051

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 283AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST243

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00402 Archaea
COG0442 LUCA
HOGENOMiHOG000167538
KOiK01881
OMAiEVYWVTH
OrthoDBiPOG093Z01RZ

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

C5A5P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVKREKWS NEFSEWYNEL LETAGIIDKR YPVKGMNVWL PYGLKIMRNI
60 70 80 90 100
EKFIHSEMAR TGHEEVLFPA LIPETEFQKE AEHIKGFEDE VYWVTHAGLD
110 120 130 140 150
PLDVRLILRP TSETAMYSMF SLWIRSHADL PFKVYQIVNV YRYETKHTRP
160 170 180 190 200
LIRVREISRF FEAHTAHVDF EDAERQIKED LEIFDRLAKF LALPYVISRR
210 220 230 240 250
PDWDKFPGAF YSLGAEIMMP DGRTLQIGTM HNYKQNFAKA YNIQYETETG
260 270 280 290 300
DHEYVHQTTF GMSERLLAAV IAVHGDDSGM VLPPTIAPIQ VVIVPIPKKD
310 320 330 340 350
ANVDVFAYAR EIAEELGKAG FRVHVDERDI RPGRKYYDWE LKGVPLRIEV
360 370 380 390 400
GPRDVEGRKA VLARRDTFEK VTVERDAIVE EVKKTLDAIH ENLYQRAKEF
410 420 430 440 450
LESHIKRVDT IEEAKAVFED RRGIVEIPWC GDEECGLKME EELDAKMLGT
460 470 480
PYPEEKAREG IEGKKCPVCG REAKFIARFA RTY
Length:483
Mass (Da):56,181
Last modified:July 28, 2009 - v1
Checksum:i89A3DA57FD926675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS33553.1
RefSeqiWP_015858667.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS33553; ACS33553; TGAM_1051
GeneIDi7986925
KEGGitga:TGAM_1051
PATRICifig|593117.10.peg.1048

Similar proteinsi

Entry informationi

Entry nameiC5A5P1_THEGJ
AccessioniPrimary (citable) accession number: C5A5P1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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