C5A4S1 (APGM_THEGJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	TGAM_0731

Organism

Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) [Complete proteome] [HAMAP]

Taxonomic identifier

593117 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_1000215197

Sequences

	Sequence		Length	Mass (Da)
	C5A4S1 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 8347227446B0332F	FASTA	411	45,583
	10 20 30 40 50 60 MKKRKGLLII LDGLGDRPIK EFGGKTPLEY AKTPNMDKLA KLGILGQQDP IKPGQPAGSD 70 80 90 100 110 120 TAHLSIFGYD PYKVYRGRGF LEALGVGLDL DEDDLAFRVN FATIENGIIT DRRAGRISTE 130 140 150 160 170 180 EAHELAKAIQ ENVKLPVDFI FVGATGHRAV LVLKGMAKGY RVGENDPHEA GKPPHRFTWE 190 200 210 220 230 240 DEESKRVAEI LEEFVRQAHE VLERHPINEK RRKEGKPVAN YLLIRGAGTY PDIPMKFTEQ 250 260 270 280 290 300 WKVRAGAVIA VSLVKGVARA IGFDVYTPEG ATGEYNTDEM AKAKKTVELL KEYDFVFLHF 310 320 330 340 350 360 KPTDAAGHDN NPKLKAEMIE KADRMIGYII EHINLEDVVI AITGDHSTPC EVMNHSGDPV 370 380 390 400 410 PLLIVGGGVR PDHTESFGER ECMRGGLGRI RGHDIVPVMM DLMNRSEKFG A

References

[1]

"Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea." Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F. Genome Biol. 10:R70.1-R70.23(2007) [PubMed: 19558674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15229 / JCM 11827 / EJ3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001398 Genomic DNA. Translation: ACS33233.1.
RefSeq	YP_002959097.1. NC_012804.1.
3D structure databases
ProteinModelPortal	C5A4S1.
ModBase	Search...
Protein-protein interaction databases
STRING	C5A4S1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7987705.
GenomeReviews	Gene locus TGAM_0731 in contig CP001398_GR.
KEGG	tga:TGAM_0731.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DIAFRCN.
ProtClustDB	PRK04024.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_THEGJ

Accession

Primary (citable) accession number: C5A4S1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program