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C5A4H7

- PUR5_THEGJ

UniProt

C5A4H7 - PUR5_THEGJ

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTGAM593117:GHFT-652-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:TGAM_0637
    OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
    Taxonomic identifieri593117 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000001488: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212831Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi593117.TGAM_0637.

    Structurei

    3D structure databases

    ProteinModelPortaliC5A4H7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiAMNAASH.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_A. AIRS_A.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C5A4H7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTYAQAGVD DEKTVRALKN IIGLARETFK FRRGKPGEPA ENLGHYSALL    50
    DFGNFYLAMT TDGVGTKVLV AEAVGKFNTI GIDMIAMNVN DLLCVGAEPI 100
    ALVDYLAVRE PDEKIFAEIA KGLYAGAEKA GIAIVGGETA VMPDLINGFD 150
    LAGTAIGIVE KGKVITGEEM RPDDAVIGIS SSGIHSNGLT LARKLLIPKY 200
    GLDYEYEGRK LWEWLLEPTR IYVRAVLELL ERVEVHGLAH ITGGGLINLK 250
    RLTNYGFSLE MPPIEGIFKL IHENGVPLEE MFRVFNMGVG FVAIVPPEEK 300
    EEALGILNKY YESFELGRVT KEPGIRVENY GIKL 334
    Length:334
    Mass (Da):36,546
    Last modified:July 28, 2009 - v1
    Checksum:i557319430623B608
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33139.1.
    RefSeqiYP_002959003.1. NC_012804.1.

    Genome annotation databases

    EnsemblBacteriaiACS33139; ACS33139; TGAM_0637.
    GeneIDi7988851.
    KEGGitga:TGAM_0637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001398 Genomic DNA. Translation: ACS33139.1 .
    RefSeqi YP_002959003.1. NC_012804.1.

    3D structure databases

    ProteinModelPortali C5A4H7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 593117.TGAM_0637.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS33139 ; ACS33139 ; TGAM_0637 .
    GeneIDi 7988851.
    KEGGi tga:TGAM_0637.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi AMNAASH.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci TGAM593117:GHFT-652-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_A. AIRS_A.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea."
      Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F.
      Genome Biol. 10:R70.1-R70.23(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 15229 / JCM 11827 / EJ3.

    Entry informationi

    Entry nameiPUR5_THEGJ
    AccessioniPrimary (citable) accession number: C5A4H7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3