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Protein

Probable dCTP deaminase

Gene

dcd

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-512-MONOMER.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:TGAM_0490
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002033681 – 157Probable dCTP deaminaseAdd BLAST157

Proteomic databases

PaxDbiC5A430.
PRIDEiC5A430.

Interactioni

Protein-protein interaction databases

STRINGi593117.TGAM_0490.

Structurei

3D structure databases

ProteinModelPortaliC5A430.
SMRiC5A430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048. Archaea.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiRTSWIRK.
OrthoDBiPOG093Z0C6C.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR036157. dUTPase-like_sf.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

C5A430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLPDWKIEK EILIEPFSKE SLQPAGYDLR VGKEAYVEGK LIDVEEAGNV
60 70 80 90 100
IIPPKKHALI LTLERVKLPD DVMGDMKIRS SLAREGILGS FAWVDPGWDG
110 120 130 140 150
NLTLMLFNAS NEPVVLEYGE RFVQIAFIRL EEPAKRPYRG NYQGSRRIAL

SKRRVRK
Length:157
Mass (Da):17,940
Last modified:July 28, 2009 - v1
Checksum:i084A801CD72259F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA. Translation: ACS32992.1.
RefSeqiWP_015858110.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS32992; ACS32992; TGAM_0490.
GeneIDi7987358.
KEGGitga:TGAM_0490.
PATRICifig|593117.10.peg.486.

Similar proteinsi

Entry informationi

Entry nameiDCD_THEGJ
AccessioniPrimary (citable) accession number: C5A430
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome