ID   C5A3B2_THEGJ            Unreviewed;       476 AA.
AC   C5A3B2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Alpha-amylase (AmyA) {ECO:0000313|EMBL:ACS32724.1};
DE            EC=3.2.1.1 {ECO:0000313|EMBL:ACS32724.1};
GN   Name=amyA-1 {ECO:0000313|EMBL:ACS32724.1};
GN   OrderedLocusNames=TGAM_0222 {ECO:0000313|EMBL:ACS32724.1};
OS   Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=593117 {ECO:0000313|EMBL:ACS32724.1, ECO:0000313|Proteomes:UP000001488};
RN   [1] {ECO:0000313|EMBL:ACS32724.1, ECO:0000313|Proteomes:UP000001488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15229 / JCM 11827 / EJ3
RC   {ECO:0000313|Proteomes:UP000001488};
RX   PubMed=19558674; DOI=10.1186/gb-2009-10-6-r70;
RA   Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M.,
RA   Anthouard V., Forterre P., Wincker P., Confalonieri F.;
RT   "Genome analysis and genome-wide proteomics of Thermococcus gammatolerans,
RT   the most radioresistant organism known amongst the Archaea.";
RL   Genome Biol. 10:R70.1-R70.23(2007).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family.
CC       {ECO:0000256|ARBA:ARBA00008061}.
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DR   EMBL; CP001398; ACS32724.1; -; Genomic_DNA.
DR   AlphaFoldDB; C5A3B2; -.
DR   STRING; 593117.TGAM_0222; -.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   PaxDb; 593117-TGAM_0222; -.
DR   KEGG; tga:TGAM_0222; -.
DR   PATRIC; fig|593117.10.peg.225; -.
DR   eggNOG; arCOG02954; Archaea.
DR   HOGENOM; CLU_024572_3_0_2; -.
DR   Proteomes; UP000001488; Chromosome.
DR   GO; GO:0004556; F:alpha-amylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd11314; AmyAc_arch_bac_plant_AmyA; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR013776; A-amylase_thermo.
DR   InterPro; IPR015237; Alpha-amylase_C_pro.
DR   InterPro; IPR006046; Alpha_amylase.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR43447; ALPHA-AMYLASE; 1.
DR   PANTHER; PTHR43447:SF49; ALPHA-AMYLASE; 1.
DR   Pfam; PF09154; Alpha-amy_C_pro; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   PIRSF; PIRSF001021; Alph-amls_thrmst; 1.
DR   PRINTS; PR00110; ALPHAAMYLASE.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:ACS32724.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ACS32724.1}.
FT   DOMAIN          50..395
FT                   /note="Glycosyl hydrolase family 13 catalytic"
FT                   /evidence="ECO:0000259|SMART:SM00642"
SQ   SEQUENCE   476 AA;  54452 MW;  A42B04BB626447C5 CRC64;
     MGVVPALSQG GMEMRRYTRV LILLMALFLL AGLYYPSASA AKYSELEQGG VIMQAFYWDV
     PAGGIWWDTI RQKIPEWYDA GISAIWIPPA SKGMGGAYSM GYDPYDYFDL GEFYQKGTVE
     TRFGSKEELV NMISTAHRYG IKVIADIVIN HRAGGDLEWN PYVGDYTWTD FSQVASGKYK
     AHYMDFHPNN YSTSDEGTFG GFPDIDHLVP FNKYWLWASD ESYAAYLRSI GVDAWRFDYV
     KGYGAWVVKD WLSWWGGWAV GEYWDTDVNA LLNWAYDSGA KVFDFPLYYK MDEAFDNKNI
     PALVYAIQNG GTVVSRDPFK AVTFVANHDT NIIWNKYPAY AFILTYEGQP VIFYRDYEEW
     LNKDKLNNLI WIHEHLAGGS TKILYYDDDE LIFMREGYGD RPGLITYINL GSGWAERWVN
     VGSKFAGYTI HEYTGNLGGW VDRYVYYNGW VKLTAPPHDP ANGYYGYSVW SYAGVG
//