C5A366 (DEOC_THEGJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	TGAM_0176

Organism

Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) [Complete proteome] [HAMAP]

Taxonomic identifier

593117 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000202971
Sites
	Active site	158	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	187	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	C5A366 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: D5441B0C69D25794	FASTA	225	24,420
	10 20 30 40 50 60 MVGMDIAKYI DHTNLKPYAT KEDIIKLCDE AIQYGFYAVC VNPYRVKLAK EYLSEKKADV 70 80 90 100 110 120 KVASVIGFPL GATPTEVKVF EARKALEDGA DELDMVINIG ALKDGDYDYV KRDIEEVVKV 130 140 150 160 170 180 AHEKGAKVKV IIETCYLTEE EKIKACELAK EAGADFVKTS TGFGTGGATV EDVRLMRKVV 190 200 210 220 GPEMGVKAAG GIRTYEQALA MIEAGANRIG TSSGVRIVEG ARNAE

References

[1]

"Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea." Zivanovic Y., Armengaud J., Lagorce A., Leplat C., Guerin P., Dutertre M., Anthouard V., Forterre P., Wincker P., Confalonieri F. Genome Biol. 10:R70.1-R70.23(2007) [PubMed: 19558674] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 15229 / JCM 11827 / EJ3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001398 Genomic DNA. Translation: ACS32678.1.
RefSeq	YP_002958542.1. NC_012804.1.
3D structure databases
ProteinModelPortal	C5A366.
ModBase	Search...
Protein-protein interaction databases
STRING	C5A366.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7988756.
GenomeReviews	Gene locus TGAM_0176 in contig CP001398_GR.
KEGG	tga:TGAM_0176.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IDHTNLK.
ProtClustDB	CLSK2395926.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_THEGJ

Accession

Primary (citable) accession number: C5A366

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	November 16, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program