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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1881-MONOMER
UniPathwayiUPA00035; UER00044

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:TGAM_1811
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002031951 – 440Tryptophan synthase beta chainAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PaxDbiC5A1P4

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1811

Structurei

3D structure databases

SMRiC5A1P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01432 Archaea
COG1350 LUCA
HOGENOMiHOG000161709
KOiK06001
OMAiPPIHAGG
OrthoDBiPOG093Z033G

Family and domain databases

CDDicd06446 Trp-synth_B, 1 hit
HAMAPiMF_00133 Trp_synth_beta, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR006316 Trp_synth_b-like
IPR006653 Trp_synth_b_CS
IPR006654 Trp_synth_beta
IPR023026 Trp_synth_beta/beta-like
IPR036052 Trypto_synt_PLP_dependent
PANTHERiPTHR43565 PTHR43565, 1 hit
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PIRSFiPIRSF001413 Trp_syn_beta, 1 hit
PIRSF500824 TrpB_prok, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01415 trpB_rel, 1 hit
PROSITEiView protein in PROSITE
PS00168 TRP_SYNTHASE_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

C5A1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLPDSKI PKRWYNILPD LPEPLAPPLD PETDEPIEPE KLLRIFAEEL
60 70 80 90 100
VKQEMSTERY IEIPKKVREL YAKIGRPTPL FRATNLEKAL GTPARIYFKY
110 120 130 140 150
EGATVTGSHK INTALAQAYY AKEQGIERLV TETGAGQWGT ALSLAGALLG
160 170 180 190 200
LKIRVYMARA SYQQKPYRKT IMRLYGAEIY PSPSDRTEIG RKFLSEDPNH
210 220 230 240 250
PGGLGIAISE AIEDVLKDEK ARYALGSVLN HVLMHQTVIG LEAQEQMKEF
260 270 280 290 300
EEPDVIIGCV GGGSNFAGLA YPFVRDVLSG KADYEFIAVE PKAAPSMTRG
310 320 330 340 350
VYKYDFGDSG GYTPKMKMHT LGHTYYVPPI HAGGLRYHGL APTLSILINH
360 370 380 390 400
GIVKPVAYHQ TEVFQAAELF AKTEGIIPAP ESAHAIKGVI DRALKAKEEG
410 420 430 440
REEVILFNLS GHGLLDLKGY EDYLDGKLED YEPDYFPALG
Length:440
Mass (Da):48,780
Last modified:July 28, 2009 - v1
Checksum:i4F2A1D5763F1C222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS34313.1
RefSeqiWP_015859422.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS34313; ACS34313; TGAM_1811
GeneIDi7987638
KEGGitga:TGAM_1811
PATRICifig|593117.10.peg.1820

Similar proteinsi

Entry informationi

Entry nameiTRPB_THEGJ
AccessioniPrimary (citable) accession number: C5A1P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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