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Protein

Tryptophan synthase beta chain

Gene

trpB

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTGAM593117:GHFT-1846-MONOMER.
UniPathwayiUPA00035; UER00044.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan synthase beta chainUniRule annotation (EC:4.2.1.20UniRule annotation)
Gene namesi
Name:trpBUniRule annotation
Ordered Locus Names:TGAM_1811
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Tryptophan synthase beta chainPRO_1000203195Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiC5A1P4.

Interactioni

Subunit structurei

Tetramer of two alpha and two beta chains.UniRule annotation

Protein-protein interaction databases

STRINGi593117.TGAM_1811.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpB family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01432. Archaea.
COG1350. LUCA.
HOGENOMiHOG000161709.
KOiK06001.
OMAiNHVMLHQ.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006316. Trp_synth_b-like.
IPR006653. Trp_synth_b_CS.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF21. PTHR10314:SF21. 2 hits.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
PIRSF500824. TrpB_prok. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01415. trpB_rel. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C5A1P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLPDSKI PKRWYNILPD LPEPLAPPLD PETDEPIEPE KLLRIFAEEL
60 70 80 90 100
VKQEMSTERY IEIPKKVREL YAKIGRPTPL FRATNLEKAL GTPARIYFKY
110 120 130 140 150
EGATVTGSHK INTALAQAYY AKEQGIERLV TETGAGQWGT ALSLAGALLG
160 170 180 190 200
LKIRVYMARA SYQQKPYRKT IMRLYGAEIY PSPSDRTEIG RKFLSEDPNH
210 220 230 240 250
PGGLGIAISE AIEDVLKDEK ARYALGSVLN HVLMHQTVIG LEAQEQMKEF
260 270 280 290 300
EEPDVIIGCV GGGSNFAGLA YPFVRDVLSG KADYEFIAVE PKAAPSMTRG
310 320 330 340 350
VYKYDFGDSG GYTPKMKMHT LGHTYYVPPI HAGGLRYHGL APTLSILINH
360 370 380 390 400
GIVKPVAYHQ TEVFQAAELF AKTEGIIPAP ESAHAIKGVI DRALKAKEEG
410 420 430 440
REEVILFNLS GHGLLDLKGY EDYLDGKLED YEPDYFPALG
Length:440
Mass (Da):48,780
Last modified:July 28, 2009 - v1
Checksum:i4F2A1D5763F1C222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA. Translation: ACS34313.1.
RefSeqiWP_015859422.1. NC_012804.1.

Genome annotation databases

EnsemblBacteriaiACS34313; ACS34313; TGAM_1811.
GeneIDi7987638.
KEGGitga:TGAM_1811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA. Translation: ACS34313.1.
RefSeqiWP_015859422.1. NC_012804.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi593117.TGAM_1811.

Proteomic databases

PaxDbiC5A1P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS34313; ACS34313; TGAM_1811.
GeneIDi7987638.
KEGGitga:TGAM_1811.

Phylogenomic databases

eggNOGiarCOG01432. Archaea.
COG1350. LUCA.
HOGENOMiHOG000161709.
KOiK06001.
OMAiNHVMLHQ.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00044.
BioCyciTGAM593117:GHFT-1846-MONOMER.

Family and domain databases

HAMAPiMF_00133. Trp_synth_beta. 1 hit.
InterProiIPR006316. Trp_synth_b-like.
IPR006653. Trp_synth_b_CS.
IPR023026. Trp_synth_beta/beta-like.
IPR001926. TrpB-like_PLP-dep.
[Graphical view]
PANTHERiPTHR10314:SF21. PTHR10314:SF21. 2 hits.
PfamiPF00291. PALP. 1 hit.
[Graphical view]
PIRSFiPIRSF001413. Trp_syn_beta. 1 hit.
PIRSF500824. TrpB_prok. 1 hit.
SUPFAMiSSF53686. SSF53686. 1 hit.
TIGRFAMsiTIGR01415. trpB_rel. 1 hit.
PROSITEiPS00168. TRP_SYNTHASE_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPB_THEGJ
AccessioniPrimary (citable) accession number: C5A1P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: July 6, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.