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Protein

AMP phosphorylase

Gene

TGAM_1786

Organism
Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciTGAM593117:G1GUW-1854-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:TGAM_1786
OrganismiThermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)
Taxonomic identifieri593117 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000001488 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126431 – 503AMP phosphorylaseAdd BLAST503

Proteomic databases

PaxDbiC5A1L9
PRIDEiC5A1L9

Interactioni

Protein-protein interaction databases

STRINGi593117.TGAM_1786

Structurei

3D structure databases

SMRiC5A1L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

C5A1L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAKVRILDV FSGRYSVFIN EEEAKKAKLH PDDLVKVESG KKTIYGSLAI
60 70 80 90 100
SNLVGPGEVG VSRDVLQLHS LSEGEVVTLT PVGTPESVRY IKKKMHGEKL
110 120 130 140 150
RKVEIEAIVR DIVDRKLRDI EISSFVTALE INGLDMDEIA ALTIAMAETG
160 170 180 190 200
DMLDIDRKPI MDVHSIGGVP GNKTNILVVP IVAAAGLTIP KTSSRAITSA
210 220 230 240 250
AGTADVVEVF TNVSFSLDEI KRIVEKVGAC LVWGGALNLA PADDITIKAE
260 270 280 290 300
RALSVDPRGL MLASIMSKKY AMGSQYVLID IPTGKGVKVE TMDEARALAR
310 320 330 340 350
DFIELGKRLG QYVEVAITYG GQPIGHTVGP ALEAREALSA LMTGKGPGSL
360 370 380 390 400
IEKALGLAGI LLEMGGVAPA GMGKKMAREI LESGKAYEKM KEIIEEQGGD
410 420 430 440 450
PNIKPEDIQI GDKTYTFTAP TSGYVTGIDN RAITGIARAA GAPEDKGAGL
460 470 480 490 500
ELYVKVGEKV KEGDPLFTIH AESEARLDQA IVFARRTEPI KIEGMVLQRI

GNI
Length:503
Mass (Da):53,823
Last modified:July 28, 2009 - v1
Checksum:iB60C4422EF02B0BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001398 Genomic DNA Translation: ACS34288.1
RefSeqiWP_015859397.1, NC_012804.1

Genome annotation databases

EnsemblBacteriaiACS34288; ACS34288; TGAM_1786
GeneIDi7987613
KEGGitga:TGAM_1786
PATRICifig|593117.10.peg.1794

Similar proteinsi

Entry informationi

Entry nameiAMPPA_THEGJ
AccessioniPrimary (citable) accession number: C5A1L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health