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Protein

Sulfurtransferase FdhD

Gene

fdhD

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei121Cysteine persulfide intermediateUniRule annotation1
Binding sitei240MolybdenumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfurtransferase FdhDUniRule annotation
Gene namesi
Name:fdhDUniRule annotation
Ordered Locus Names:BWG_3565
OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
Taxonomic identifieri595496 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002039671 – 277Sulfurtransferase FdhDAdd BLAST277

Structurei

3D structure databases

ProteinModelPortaliC5A063.
SMRiC5A063.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni260 – 265Molybdenum bindingUniRule annotation6

Sequence similaritiesi

Belongs to the FdhD family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000079468.
KOiK02379.
OMAiPFTQTFS.

Family and domain databases

HAMAPiMF_00187. FdhD. 1 hit.
InterProiIPR016193. Cytidine_deaminase-like.
IPR003786. FdhD.
[Graphical view]
PfamiPF02634. FdhD-NarQ. 1 hit.
[Graphical view]
PIRSFiPIRSF015626. FdhD. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00129. fdhD_narQ. 1 hit.

Sequencei

Sequence statusi: Complete.

C5A063-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTQRKEIE NVTNITGVRQ IELWRRDDLQ HPRLDEVAEE VPVALVYNGI
60 70 80 90 100
SHVVMMASPK DLEYFALGFS LSEGIIESPR DIFGMDVVPS CNGLEVQIEL
110 120 130 140 150
SSRRFMGLKE RRRALAGRTG CGVCGVEQLN DIGKPVQPLP FTQTFDLNKL
160 170 180 190 200
DDALRHLNDF QPVGQLTGCT HAAAWMLPSG ELVGGHEDVG RHVALDKLLG
210 220 230 240 250
RRSQEGESWQ QGAVLVSSRA SYEMVQKSAM CGVEILFAVS AATTLAVEVA
260 270
ERCNLTLVGF CKPGRATVYT HPQRLSN
Length:277
Mass (Da):30,560
Last modified:July 28, 2009 - v1
Checksum:i9E42BBDCB5B3D0F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63125.1.
RefSeqiWP_000753617.1. NC_012759.1.

Genome annotation databases

EnsemblBacteriaiACR63125; ACR63125; BWG_3565.
KEGGiebw:BWG_3565.
PATRICi18276843. VBIEscCol60876_3895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63125.1.
RefSeqiWP_000753617.1. NC_012759.1.

3D structure databases

ProteinModelPortaliC5A063.
SMRiC5A063.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR63125; ACR63125; BWG_3565.
KEGGiebw:BWG_3565.
PATRICi18276843. VBIEscCol60876_3895.

Phylogenomic databases

HOGENOMiHOG000079468.
KOiK02379.
OMAiPFTQTFS.

Family and domain databases

HAMAPiMF_00187. FdhD. 1 hit.
InterProiIPR016193. Cytidine_deaminase-like.
IPR003786. FdhD.
[Graphical view]
PfamiPF02634. FdhD-NarQ. 1 hit.
[Graphical view]
PIRSFiPIRSF015626. FdhD. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00129. fdhD_narQ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFDHD_ECOBW
AccessioniPrimary (citable) accession number: C5A063
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.