Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C4ZZY4 (MUTH_ECOBW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutH
Alternative name(s):
Methyl-directed mismatch repair protein
Gene names
Name:mutH
Ordered Locus Names:BWG_2567
OrganismEscherichia coli (strain K12 / MC4100 / BW2952) [Complete proteome] [HAMAP]
Taxonomic identifier595496 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00759.

Sequence similarities

Belongs to the MutH family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA modification

Inferred from electronic annotation. Source: InterPro

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: InterPro

endonuclease activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229DNA mismatch repair protein MutH HAMAP-Rule MF_00759
PRO_1000212878

Sequences

Sequence LengthMass (Da)Tools
C4ZZY4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 32543989D710A8FD

FASTA22925,527
        10         20         30         40         50         60 
MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW IGVLLEIWLG 

        70         80         90        100        110        120 
ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV 

       130        140        150        160        170        180 
LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY 

       190        200        210        220 
LQIRPKAANA KALTEAIGAR GERILTLPRG FYLKKNFTSA LLARHFLIQ 

« Hide

References

[1]"Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12."
Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L.
J. Bacteriol. 191:4025-4029(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MC4100 / BW2952.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001396 Genomic DNA. Translation: ACR63764.1.
RefSeqYP_002927763.1. NC_012759.1.

3D structure databases

ProteinModelPortalC4ZZY4.
SMRC4ZZY4. Positions 3-229.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING595496.BWG_2567.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR63764; ACR63764; BWG_2567.
GeneID7953970.
KEGGebw:BWG_2567.
PATRIC18274618. VBIEscCol60876_2812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3066.
HOGENOMHOG000271839.
KOK03573.
OMALRPKGAN.
OrthoDBEOG6CGCC0.

Enzyme and pathway databases

BioCycECOL595496:GI18-2668-MONOMER.

Family and domain databases

Gene3D3.40.600.10. 1 hit.
HAMAPMF_00759. MutH.
InterProIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamPF02976. MutH. 1 hit.
[Graphical view]
SMARTSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMSSF52980. SSF52980. 1 hit.
TIGRFAMsTIGR02248. mutH_TIGR. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMUTH_ECOBW
AccessionPrimary (citable) accession number: C4ZZY4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families