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C4ZZY4

- MUTH_ECOBW

UniProt

C4ZZY4 - MUTH_ECOBW

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Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA modification Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciECOL595496:GI18-2668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutHUniRule annotation
Alternative name(s):
Methyl-directed mismatch repair proteinUniRule annotation
Gene namesi
Name:mutHUniRule annotation
Ordered Locus Names:BWG_2567
OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
Taxonomic identifieri595496 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000001478: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229DNA mismatch repair protein MutHPRO_1000212878Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi595496.BWG_2567.

Structurei

3D structure databases

ProteinModelPortaliC4ZZY4.
SMRiC4ZZY4. Positions 3-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MutH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3066.
HOGENOMiHOG000271839.
KOiK03573.
OMAiLRPKGAN.
OrthoDBiEOG6CGCC0.

Family and domain databases

Gene3Di3.40.600.10. 1 hit.
HAMAPiMF_00759. MutH.
InterProiIPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view]
PfamiPF02976. MutH. 1 hit.
[Graphical view]
SMARTiSM00927. MutH. 1 hit.
[Graphical view]
SUPFAMiSSF52980. SSF52980. 1 hit.
TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

Sequencei

Sequence statusi: Complete.

C4ZZY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW
60 70 80 90 100
IGVLLEIWLG ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL
110 120 130 140 150
TGNSGVTWET SHVRHKLKRV LWIPVEGERS IPLAQRRVGS PLLWSPNEEE
160 170 180 190 200
DRQLREDWEE LMDMIVLGQV ERITARHGEY LQIRPKAANA KALTEAIGAR
210 220
GERILTLPRG FYLKKNFTSA LLARHFLIQ
Length:229
Mass (Da):25,527
Last modified:July 28, 2009 - v1
Checksum:i32543989D710A8FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63764.1.
RefSeqiYP_002927763.1. NC_012759.1.

Genome annotation databases

EnsemblBacteriaiACR63764; ACR63764; BWG_2567.
GeneIDi7953970.
KEGGiebw:BWG_2567.
PATRICi18274618. VBIEscCol60876_2812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63764.1 .
RefSeqi YP_002927763.1. NC_012759.1.

3D structure databases

ProteinModelPortali C4ZZY4.
SMRi C4ZZY4. Positions 3-229.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 595496.BWG_2567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR63764 ; ACR63764 ; BWG_2567 .
GeneIDi 7953970.
KEGGi ebw:BWG_2567.
PATRICi 18274618. VBIEscCol60876_2812.

Phylogenomic databases

eggNOGi COG3066.
HOGENOMi HOG000271839.
KOi K03573.
OMAi LRPKGAN.
OrthoDBi EOG6CGCC0.

Enzyme and pathway databases

BioCyci ECOL595496:GI18-2668-MONOMER.

Family and domain databases

Gene3Di 3.40.600.10. 1 hit.
HAMAPi MF_00759. MutH.
InterProi IPR004230. DNA_mismatch_repair_MutH.
IPR011337. DNA_rep_MutH/RE_typeII.
IPR011335. Restrct_endonuc-II-like.
[Graphical view ]
Pfami PF02976. MutH. 1 hit.
[Graphical view ]
SMARTi SM00927. MutH. 1 hit.
[Graphical view ]
SUPFAMi SSF52980. SSF52980. 1 hit.
TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12."
    Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L.
    J. Bacteriol. 191:4025-4029(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MC4100 / BW2952.

Entry informationi

Entry nameiMUTH_ECOBW
AccessioniPrimary (citable) accession number: C4ZZY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3