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C4ZZY4

- MUTH_ECOBW

UniProt

C4ZZY4 - MUTH_ECOBW

Protein

DNA mismatch repair protein MutH

Gene

mutH

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. endonuclease activity Source: UniProtKB-KW

    GO - Biological processi

    1. DNA modification Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciECOL595496:GI18-2668-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutHUniRule annotation
    Alternative name(s):
    Methyl-directed mismatch repair proteinUniRule annotation
    Gene namesi
    Name:mutHUniRule annotation
    Ordered Locus Names:BWG_2567
    OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
    Taxonomic identifieri595496 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001478: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229DNA mismatch repair protein MutHPRO_1000212878Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi595496.BWG_2567.

    Structurei

    3D structure databases

    ProteinModelPortaliC4ZZY4.
    SMRiC4ZZY4. Positions 3-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MutH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3066.
    HOGENOMiHOG000271839.
    KOiK03573.
    OMAiLRPKGAN.
    OrthoDBiEOG6CGCC0.

    Family and domain databases

    Gene3Di3.40.600.10. 1 hit.
    HAMAPiMF_00759. MutH.
    InterProiIPR004230. DNA_mismatch_repair_MutH.
    IPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view]
    PfamiPF02976. MutH. 1 hit.
    [Graphical view]
    SMARTiSM00927. MutH. 1 hit.
    [Graphical view]
    SUPFAMiSSF52980. SSF52980. 1 hit.
    TIGRFAMsiTIGR02248. mutH_TIGR. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4ZZY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW    50
    IGVLLEIWLG ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL 100
    TGNSGVTWET SHVRHKLKRV LWIPVEGERS IPLAQRRVGS PLLWSPNEEE 150
    DRQLREDWEE LMDMIVLGQV ERITARHGEY LQIRPKAANA KALTEAIGAR 200
    GERILTLPRG FYLKKNFTSA LLARHFLIQ 229
    Length:229
    Mass (Da):25,527
    Last modified:July 28, 2009 - v1
    Checksum:i32543989D710A8FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001396 Genomic DNA. Translation: ACR63764.1.
    RefSeqiYP_002927763.1. NC_012759.1.

    Genome annotation databases

    EnsemblBacteriaiACR63764; ACR63764; BWG_2567.
    GeneIDi7953970.
    KEGGiebw:BWG_2567.
    PATRICi18274618. VBIEscCol60876_2812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001396 Genomic DNA. Translation: ACR63764.1 .
    RefSeqi YP_002927763.1. NC_012759.1.

    3D structure databases

    ProteinModelPortali C4ZZY4.
    SMRi C4ZZY4. Positions 3-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595496.BWG_2567.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR63764 ; ACR63764 ; BWG_2567 .
    GeneIDi 7953970.
    KEGGi ebw:BWG_2567.
    PATRICi 18274618. VBIEscCol60876_2812.

    Phylogenomic databases

    eggNOGi COG3066.
    HOGENOMi HOG000271839.
    KOi K03573.
    OMAi LRPKGAN.
    OrthoDBi EOG6CGCC0.

    Enzyme and pathway databases

    BioCyci ECOL595496:GI18-2668-MONOMER.

    Family and domain databases

    Gene3Di 3.40.600.10. 1 hit.
    HAMAPi MF_00759. MutH.
    InterProi IPR004230. DNA_mismatch_repair_MutH.
    IPR011337. DNA_rep_MutH/RE_typeII.
    IPR011335. Restrct_endonuc-II-like.
    [Graphical view ]
    Pfami PF02976. MutH. 1 hit.
    [Graphical view ]
    SMARTi SM00927. MutH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52980. SSF52980. 1 hit.
    TIGRFAMsi TIGR02248. mutH_TIGR. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12."
      Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L.
      J. Bacteriol. 191:4025-4029(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MC4100 / BW2952.

    Entry informationi

    Entry nameiMUTH_ECOBW
    AccessioniPrimary (citable) accession number: C4ZZY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3