C4ZZY4 (MUTH_ECOBW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein MutH

Alternative name(s):
Methyl-directed mismatch repair protein

Gene names

Name:	mutH
Ordered Locus Names:	BWG_2567

Organism

Escherichia coli (strain K12 / MC4100 / BW2952) [Complete proteome] [HAMAP]

Taxonomic identifier

595496 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli › Escherichia coli (strain K12)

Protein attributes

Sequence length	229 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair By similarity. HAMAP-Rule MF_00759
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MutH family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Cytoplasm
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA modification Inferred from electronic annotation. Source: InterPro mismatch repair Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro endonuclease activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 229	229	DNA mismatch repair protein MutH HAMAP-Rule MF_00759		PRO_1000212878

Sequences

	Sequence		Length	Mass (Da)
	C4ZZY4 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 32543989D710A8FD	FASTA	229	25,527
	10 20 30 40 50 60 MSQPRPLLSP PETEEQLLAQ AQQLSGYTLG ELAALVGLVT PENLKRDKGW IGVLLEIWLG 70 80 90 100 110 120 ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV 130 140 150 160 170 180 LWIPVEGERS IPLAQRRVGS PLLWSPNEEE DRQLREDWEE LMDMIVLGQV ERITARHGEY 190 200 210 220 LQIRPKAANA KALTEAIGAR GERILTLPRG FYLKKNFTSA LLARHFLIQ

References

[1]

"Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12." Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L. J. Bacteriol. 191:4025-4029(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MC4100 / BW2952.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001396 Genomic DNA. Translation: ACR63764.1.
RefSeq	YP_002927763.1. NC_012759.1.
3D structure databases
ProteinModelPortal	C4ZZY4.
SMR	C4ZZY4. Positions 3-229.
ModBase	Search...
Protein-protein interaction databases
STRING	595496.BWG_2567.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACR63764; ACR63764; BWG_2567.
GeneID	7953970.
KEGG	ebw:BWG_2567.
PATRIC	18274618. VBIEscCol60876_2812.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3066.
HOGENOM	HOG000271839.
KO	K03573.
OMA	LRPKGAN.
ProtClustDB	PRK05070.
Enzyme and pathway databases
BioCyc	ECOL595496:GI18-2222-MONOMER.
Family and domain databases
Gene3D	3.40.600.10. 1 hit.
HAMAP	MF_00759. MutH.
InterPro	IPR004230. DNA_mismatch_repair_MutH. IPR011337. DNA_rep_MutH/RE_typeII. IPR011335. Restrct_endonuc-II-like. [Graphical view]
Pfam	PF02976. MutH. 1 hit. [Graphical view]
SMART	SM00927. MutH. 1 hit. [Graphical view]
SUPFAM	SSF52980. Restrict_endonuc_II-like_core. 1 hit.
TIGRFAMs	TIGR02248. mutH_TIGR. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MUTH_ECOBW

Accession

Primary (citable) accession number: C4ZZY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program