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Protein

Small heat shock protein IbpA

Gene

ibpA

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciECOL595496:GI18-3508-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small heat shock protein IbpAUniRule annotation
Alternative name(s):
16 kDa heat shock protein AUniRule annotation
Gene namesi
Name:ibpAUniRule annotation
Ordered Locus Names:BWG_3377
OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
Taxonomic identifieri595496 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Small heat shock protein IbpAPRO_1000216227Add
BLAST

Proteomic databases

PRIDEiC4ZYW4.

Interactioni

Subunit structurei

Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4ZYW4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04080.
OMAiTAHDNML.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02000. HSP20_IbpA. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR023728. HSP20_IbpA.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4ZYW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNFDLSPLY RSAIGFDRLF NHLENNQSQS NGGYPPYNVE LVDENHYRIA
60 70 80 90 100
IAVAGFAESE LEITAQDNLL VVKGAHADEQ KERTYLYQGI AERNFERKFQ
110 120 130
LAENIHVRGA NLVNGLLYID LERVIPEAKK PRRIEIN
Length:137
Mass (Da):15,774
Last modified:July 28, 2009 - v1
Checksum:iE7BB51421F5CEF3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63400.1.
RefSeqiWP_001243437.1. NC_012759.1.

Genome annotation databases

EnsemblBacteriaiACR63400; ACR63400; BWG_3377.
KEGGiebw:BWG_3377.
PATRICi18276404. VBIEscCol60876_3691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR63400.1.
RefSeqiWP_001243437.1. NC_012759.1.

3D structure databases

ProteinModelPortaliC4ZYW4.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC4ZYW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR63400; ACR63400; BWG_3377.
KEGGiebw:BWG_3377.
PATRICi18276404. VBIEscCol60876_3691.

Phylogenomic databases

HOGENOMiHOG000251750.
KOiK04080.
OMAiTAHDNML.

Enzyme and pathway databases

BioCyciECOL595496:GI18-3508-MONOMER.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
HAMAPiMF_02000. HSP20_IbpA. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
IPR023728. HSP20_IbpA.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBPA_ECOBW
AccessioniPrimary (citable) accession number: C4ZYW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: September 7, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.