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C4ZYF4

- YDIB_ECOBW

UniProt

C4ZYF4 - YDIB_ECOBW

Protein

Quinate/shikimate dehydrogenase

Gene

ydiB

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-quinate + NAD(P)+ = 3-dehydroquinate + NAD(P)H.UniRule annotation
    Shikimate + NAD(P)+ = 3-dehydroshikimate + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711Proton acceptorUniRule annotation
    Binding sitei107 – 1071SubstrateUniRule annotation
    Binding sitei205 – 2051NAD; via amide nitrogenUniRule annotation
    Binding sitei235 – 2351NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi131 – 1355NADUniRule annotation
    Nucleotide bindingi155 – 1584NADUniRule annotation
    Nucleotide bindingi255 – 2595NADUniRule annotation

    GO - Molecular functioni

    1. quinate 3-dehydrogenase (NAD+) activity Source: UniProtKB-HAMAP
    2. quinate 3-dehydrogenase (NADP+) activity Source: UniProtKB-EC
    3. shikimate 3-dehydrogenase (NAD+) activity Source: UniProtKB-EC
    4. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciECOL595496:GI18-1556-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Quinate/shikimate dehydrogenaseUniRule annotation (EC:1.1.1.282UniRule annotation)
    Alternative name(s):
    NAD-dependent shikimate 5-dehydrogenase 2UniRule annotation
    Gene namesi
    Name:ydiBUniRule annotation
    Ordered Locus Names:BWG_1506
    OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
    Taxonomic identifieri595496 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000001478: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Quinate/shikimate dehydrogenasePRO_1000215614Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi595496.BWG_1506.

    Structurei

    3D structure databases

    ProteinModelPortaliC4ZYF4.
    SMRiC4ZYF4. Positions 5-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0169.
    HOGENOMiHOG000237875.
    KOiK05887.
    OMAiERIWLGV.
    OrthoDBiEOG64R67G.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    MF_01578. Shikimate_DH_YdiB.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR022872. Quinate/Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4ZYF4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVTAKYELI GLMAYPIRHS LSPEMQNKAL EKAGLPFTYM AFEVDNDSFP    50
    GAIEGLKALK MRGTGVSMPN KQLACEYVDE LTPAAKLVGA INTIVNDDGY 100
    LRGYNTDGTG HIRAIKESGF DIKGKTMVLL GAGGASTAIG AQGAIEGLKE 150
    IKLFNRRDEF FDKALAFAQR VNENTDCVVT VTDLADQQAF AEALASADIL 200
    TNGTKVGMKP LENESLVNDI SLLHPGLLVT ECVYNPHMTK LLQQAQQAGC 250
    KTIDGYGMLL WQGAEQFTLW TGKDFPLEYV KQVMGFGA 288
    Length:288
    Mass (Da):31,228
    Last modified:July 28, 2009 - v1
    Checksum:iC3D1415E03820A5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001396 Genomic DNA. Translation: ACR65393.1.
    RefSeqiYP_002926703.1. NC_012759.1.

    Genome annotation databases

    EnsemblBacteriaiACR65393; ACR65393; BWG_1506.
    GeneIDi7955690.
    KEGGiebw:BWG_1506.
    PATRICi18272239. VBIEscCol60876_1652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001396 Genomic DNA. Translation: ACR65393.1 .
    RefSeqi YP_002926703.1. NC_012759.1.

    3D structure databases

    ProteinModelPortali C4ZYF4.
    SMRi C4ZYF4. Positions 5-288.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 595496.BWG_1506.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR65393 ; ACR65393 ; BWG_1506 .
    GeneIDi 7955690.
    KEGGi ebw:BWG_1506.
    PATRICi 18272239. VBIEscCol60876_1652.

    Phylogenomic databases

    eggNOGi COG0169.
    HOGENOMi HOG000237875.
    KOi K05887.
    OMAi ERIWLGV.
    OrthoDBi EOG64R67G.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci ECOL595496:GI18-1556-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    MF_01578. Shikimate_DH_YdiB.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR022872. Quinate/Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12."
      Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L.
      J. Bacteriol. 191:4025-4029(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K12 / MC4100 / BW2952.

    Entry informationi

    Entry nameiYDIB_ECOBW
    AccessioniPrimary (citable) accession number: C4ZYF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3