UniProtKB - C4ZWF6 (SYQ_ECOBW)
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Protein
Glutamine--tRNA ligase
Gene
glnS
Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Functioni
Catalytic activityi
ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 67 | L-glutamineUniRule annotation | 1 | |
Binding sitei | 212 | L-glutamineUniRule annotation | 1 | |
Binding sitei | 231 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 35 – 37 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 41 – 47 | ATPUniRule annotation | 7 | |
Nucleotide bindingi | 261 – 262 | ATPUniRule annotation | 2 | |
Nucleotide bindingi | 269 – 271 | ATPUniRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamine-tRNA ligase activity Source: UniProtKB-EC
GO - Biological processi
- glutaminyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamine--tRNA ligaseUniRule annotation (EC:6.1.1.18UniRule annotation)Alternative name(s): Glutaminyl-tRNA synthetaseUniRule annotation Short name: GlnRSUniRule annotation |
Gene namesi | Name:glnSUniRule annotation Ordered Locus Names:BWG_0540 |
Organismi | Escherichia coli (strain K12 / MC4100 / BW2952) |
Taxonomic identifieri | 595496 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000203121 | 1 – 554 | Glutamine--tRNA ligaseAdd BLAST | 554 |
Proteomic databases
PRIDEi | C4ZWF6. |
Interactioni
Subunit structurei
Monomer.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | C4ZWF6. |
SMRi | C4ZWF6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 317 – 324 | Interaction with tRNAUniRule annotation | 8 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 34 – 44 | "HIGH" regionUniRule annotationAdd BLAST | 11 | |
Motifi | 268 – 272 | "KMSKS" regionUniRule annotation | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000259232. |
KOi | K01886. |
OMAi | VTHSICT. |
Family and domain databases
Gene3Di | 1.10.1160.10. 1 hit. 2.40.240.10. 2 hits. 3.40.50.620. 2 hits. |
HAMAPi | MF_00126. Gln_tRNA_synth. 1 hit. |
InterProi | View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR004514. Gln-tRNA-synth. IPR022861. Gln_tRNA_ligase_bac. IPR000924. Glu/Gln-tRNA-synth. IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom. IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd. IPR020061. Glu_tRNA_lig_a-bdl. IPR020056. Rbsml_L25/Gln-tRNA_synth_N. IPR011035. Ribosomal_L25/Gln-tRNA_synth. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF00749. tRNA-synt_1c. 1 hit. PF03950. tRNA-synt_1c_C. 1 hit. |
PRINTSi | PR00987. TRNASYNTHGLU. |
SUPFAMi | SSF50715. SSF50715. 1 hit. |
TIGRFAMsi | TIGR00440. glnS. 1 hit. |
PROSITEi | View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
C4ZWF6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEAEARPTN FIRQIIDEDL ASGKHTTVHT RFPPEPNGYL HIGHAKSICL
60 70 80 90 100
NFGIAQDYKG QCNLRFDDTN PVKEDIEYVE SIKNDVEWLG FHWSGNVRYS
110 120 130 140 150
SDYFDQLHAY AIELINKGLA YVDELTPEQI REYRGTLTQP GKNSPYRDRS
160 170 180 190 200
VEENLALFEK MRAGGFEEGK ACLRAKIDMA SPFIVMRDPV LYRIKFAEHH
210 220 230 240 250
QTGNKWCIYP MYDFTHCISD ALEGITHSLC TLEFQDNRRL YDWVLDNITI
260 270 280 290 300
PVHPRQYEFS RLNLEYTVMS KRKLNLLVTD KHVEGWDDPR MPTISGLRRR
310 320 330 340 350
GYTAASIREF CKRIGVTKQD NTIEMASLES CIREDLNENA PRAMAVIDPV
360 370 380 390 400
KLVIENYQGE GEMVTMPNHP NKPEMGSRQV PFSGEIWIDR ADFREEANKQ
410 420 430 440 450
YKRLVLGKEV RLRNAYVIKA ERVEKDAEGN ITTIFCTYDA DTLSKDPADG
460 470 480 490 500
RKVKGVIHWV SAAHALPVEI RLYDRLFSVP NPGAADDFLS VINPESLVIK
510 520 530 540 550
QGFAEPSLKD AVAGKAFQFE REGYFCLDSR HSTAEKPVFN RTVGLRDTWA
KVGE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001396 Genomic DNA. Translation: ACR63343.1. |
RefSeqi | WP_001287154.1. NC_012759.1. |
Genome annotation databases
EnsemblBacteriai | ACR63343; ACR63343; BWG_0540. |
KEGGi | ebw:BWG_0540. |
Similar proteinsi
Entry informationi
Entry namei | SYQ_ECOBW | |
Accessioni | C4ZWF6Primary (citable) accession number: C4ZWF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 28, 2018 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |