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C4ZTB5 (ACDH_ECOBW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:mhpF
Ordered Locus Names:BWG_0240
OrganismEscherichia coli (strain K12 / MC4100 / BW2952) [Complete proteome] [HAMAP]
Taxonomic identifier595496 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation. HAMAP MF_01657

Subunit structure

Interacts with MhpE By similarity. HAMAP MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Acetaldehyde dehydrogenase HAMAP MF_01657
PRO_1000215854

Regions

Nucleotide binding11 – 144NAD By similarity
Nucleotide binding162 – 1709NAD By similarity

Sites

Binding site2891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
C4ZTB5 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: A6918BDA5EF4876B

FASTA31633,442
        10         20         30         40         50         60 
MSKRKVAIIG SGNIGTDLMI KILRHGQHLE MAVMVGIDPQ SDGLARARRM GVATTHEGVI 

        70         80         90        100        110        120 
GLMNMPEFAD IDIVFDATSA GAHVKNDAAL REAKPDIRLI DLTPAAIGPY CVPVVNLEAN 

       130        140        150        160        170        180 
VDQLNVNMVT CGGQATIPMV AAVSRVARVH YAEIIASIAS KSAGPGTRAN IDEFTETTSR 

       190        200        210        220        230        240 
AIEVVGGAAK GKAIIVLNPA EPPLMMRDTV YVLSDEASQD DIEASINEMA EAVQAYVPGY 

       250        260        270        280        290        300 
RLKQRVQFEV IPQDKPVNLP GVGQFSGLKT AVWLEVEGAA HYLPAYAGNL DIMTSSALAT 

       310 
AEKMAQSLAR KAGEAA

« Hide

References

[1]"Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12."
Ferenci T., Zhou Z., Betteridge T., Ren Y., Liu Y., Feng L., Reeves P.R., Wang L.
J. Bacteriol. 191:4025-4029(2009) [PubMed: 19376874] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MC4100 / BW2952.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001396 Genomic DNA. Translation: ACR61896.1.
RefSeqYP_002925442.1. NC_012759.1.

3D structure databases

ProteinModelPortalC4ZTB5.
SMRC4ZTB5. Positions 3-308.
ModBaseSearch...

Protein-protein interaction databases

STRINGC4ZTB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000153235; EBESCP00000143296; EBESCG00000151598.
GeneID7952261.
GenomeReviewsGene locus BWG_0240 in contig CP001396_GR.
KEGGebw:BWG_0240.
PATRIC18269416. VBIEscCol60876_0264.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000011515.
OMAHVKNDAF.
ProtClustDBPRK08300.

Family and domain databases

HAMAPMF_01657. Ac_ald_DH_ac.
[Tree]
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK04073.
PANTHERPTHR21123. Acetylald_dh. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_ECOBW
AccessionPrimary (citable) accession number: C4ZTB5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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