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Protein

Ribosomal RNA large subunit methyltransferase I

Gene

rlmI

Organism
Escherichia coli (strain K12 / MC4100 / BW2952)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1962) in 23S rRNA = S-adenosyl-L-homocysteine + 5-methylcytosine(1962) in 23S rRNA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase IUniRule annotation (EC:2.1.1.191UniRule annotation)
Alternative name(s):
23S rRNA m5C1962 methyltransferaseUniRule annotation
rRNA (cytosine-C(5)-)-methyltransferase RlmIUniRule annotation
Gene namesi
Name:rlmIUniRule annotation
Ordered Locus Names:BWG_0819
OrganismiEscherichia coli (strain K12 / MC4100 / BW2952)
Taxonomic identifieri595496 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

C4ZQ93:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002161541 – 396Ribosomal RNA large subunit methyltransferase IAdd BLAST396

Structurei

3D structure databases

ProteinModelPortaliC4ZQ93.
SMRiC4ZQ93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 81PUAUniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000266009.
KOiK06969.
OMAiFDYFKYA.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
HAMAPiMF_01857. 23SrRNA_methyltr_I. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR036974. PUA_sf.
IPR023542. rRNA_lsu_MeTfrase_I.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF10672. Methyltrans_SAM. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
SSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4ZQ93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRLVLAKG REKSLLRRHP WVFSGAVARM EGKASLGETI DIVDHQGKWL
60 70 80 90 100
ARGAYSPASQ IRARVWTFDP SESIDIAFFS RRLQQAQKWR DWLAQKDGLD
110 120 130 140 150
SYRLIAGESD GLPGITIDRF GNFLVLQLLS AGAEYQRAAL ISALQTLYPE
160 170 180 190 200
CSIYDRSDVA VRKKEGMELT QGPVTGELPP ALLPIEEHGM KLLVDIQHGH
210 220 230 240 250
KTGYYLDQRD SRLATRRYVE NKRVLNCFSY TGGFAVSALM GGCSQVVSVD
260 270 280 290 300
TSQEALDIAR QNVELNKLDL SKAEFVRDDV FKLLRTYRDR GEKFDVIVMD
310 320 330 340 350
PPKFVENKSQ LMGACRGYKD INMLAIQLLN EGGILLTFSC SGLMTSDLFQ
360 370 380 390
KIIADAAIDA GRDVQFIEQF RQAADHPVIA TYPEGLYLKG FACRVM
Length:396
Mass (Da):44,357
Last modified:July 28, 2009 - v1
Checksum:i09C5ECEB62733D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001396 Genomic DNA. Translation: ACR64660.1.
RefSeqiWP_000116297.1. NC_012759.1.

Genome annotation databases

EnsemblBacteriaiACR64660; ACR64660; BWG_0819.
KEGGiebw:BWG_0819.

Similar proteinsi

Entry informationi

Entry nameiRLMI_ECOBW
AccessioniPrimary (citable) accession number: C4ZQ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 25, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families