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C4ZI07

- MUTS2_EUBR3

UniProt

C4ZI07 - MUTS2_EUBR3

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Protein

Endonuclease MutS2

Gene

mutS2

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi334 – 3418ATPUniRule annotation

GO - Molecular functioni

  1. ATPase activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. endonuclease activity Source: UniProtKB-HAMAP
  4. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: InterPro
  2. negative regulation of DNA recombination Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEREC515619:GHMX-2904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:mutS2UniRule annotation
Ordered Locus Names:EUBREC_2915
OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
Taxonomic identifieri515619 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001477: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792Endonuclease MutS2PRO_1000202680Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi515619.EUBREC_2915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini717 – 79276SmrUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
Contains 1 Smr domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiFGGIVHD.
OrthoDBiEOG6P5ZC4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4ZI07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKKVYKTLE YNKILTMLSS YAACDETKKR CLSLEPITDL YEIRHLQTTT
60 70 80 90 100
ADALSRLYKD SGVSFVGIHN VHASLKRLDI GGALNTTELL RICSLLEVAK
110 120 130 140 150
RVKAYGRSAM DNEKQDSLSG LFAGIEPVSA LCDEIKRCIL SEEEIADDAS
160 170 180 190 200
PELFKIRKSI RGMNDRIHAQ LTKLMNNSTT RTYLQDAVVT MRDGRYCLPV
210 220 230 240 250
KAEAKGNVPG MMHDQSSTGS TLFIEPMAVV NLNNELKELF IKEQEEIEKI
260 270 280 290 300
LAALSDKVAM NAAALEQDYE ILSELDFIFA KANLAKSYNG VAPDFNTDGH
310 320 330 340 350
INIRKGRHPL LDAKKVVPID VRLGEDYKQL IITGPNTGGK TVSLKTVGLL
360 370 380 390 400
TLMGQAGLHI PAADRSKLAI FEDVFADIGD EQSIEQSLST FSSHMTNIVK
410 420 430 440 450
ILEKADDRSL CLFDELCSGT DPTEGAALAI SILNRLHQYG AITMATTHYS
460 470 480 490 500
ELKVYALSTD GVENACCEFN VETLSPTYRL LIGIPGKSNA FAISSKLGLD
510 520 530 540 550
ENIIEDAKSR INDNDLDFED LIASLESQRQ TIEKEQLEIN SYKAEIEKLK
560 570 580 590 600
KQLEEKNERI DKSKDKILRE ANEEAYKILQ DAKELADKTI RNFNKYGQGQ
610 620 630 640 650
APMSQMEKER SALRDKMNDK EKKLSDIKKN TAKANHKAPK KLRIGDSVLV
660 670 680 690 700
LSLNLKGTVH TLPNAKGDLY VQMGILRSLV NINDLVLLND DVSPAKKYGG
710 720 730 740 750
SGSKIKMSKS LSVSSEINLI GKTTDEALAL LDKYLDDAYI AHLSSVRIVH
760 770 780 790
GKGTGALRKA VHGLLKRTKT IAEYHLGEFG EGDAGVTIAT FK
Length:792
Mass (Da):87,574
Last modified:July 28, 2009 - v1
Checksum:i4246F3B54A909D71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR76644.1.
RefSeqiYP_002938778.1. NC_012781.1.

Genome annotation databases

EnsemblBacteriaiACR76644; ACR76644; EUBREC_2915.
GeneIDi7963414.
KEGGiere:EUBREC_2915.
PATRICi21873795. VBIEubRec107985_2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR76644.1 .
RefSeqi YP_002938778.1. NC_012781.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515619.EUBREC_2915.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR76644 ; ACR76644 ; EUBREC_2915 .
GeneIDi 7963414.
KEGGi ere:EUBREC_2915.
PATRICi 21873795. VBIEubRec107985_2536.

Phylogenomic databases

eggNOGi COG1193.
HOGENOMi HOG000135096.
KOi K07456.
OMAi FGGIVHD.
OrthoDBi EOG6P5ZC4.

Enzyme and pathway databases

BioCyci EREC515619:GHMX-2904-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00092. MutS2.
InterProi IPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view ]
PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
Pfami PF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view ]
PIRSFi PIRSF005814. MutS_YshD. 1 hit.
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01069. mutS2. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33656 / VPI 0990.

Entry informationi

Entry nameiMUTS2_EUBR3
AccessioniPrimary (citable) accession number: C4ZI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3