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Protein

Endonuclease MutS2

Gene

mutS2

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi334 – 3418ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEREC515619:GHMX-2904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
Gene namesi
Name:mutS2UniRule annotation
Ordered Locus Names:EUBREC_2915
OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
Taxonomic identifieri515619 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001477 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792Endonuclease MutS2PRO_1000202680Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini717 – 79276SmrUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
Contains 1 Smr domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiHMTHIVE.
OrthoDBiEOG6P5ZC4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4ZI07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKKVYKTLE YNKILTMLSS YAACDETKKR CLSLEPITDL YEIRHLQTTT
60 70 80 90 100
ADALSRLYKD SGVSFVGIHN VHASLKRLDI GGALNTTELL RICSLLEVAK
110 120 130 140 150
RVKAYGRSAM DNEKQDSLSG LFAGIEPVSA LCDEIKRCIL SEEEIADDAS
160 170 180 190 200
PELFKIRKSI RGMNDRIHAQ LTKLMNNSTT RTYLQDAVVT MRDGRYCLPV
210 220 230 240 250
KAEAKGNVPG MMHDQSSTGS TLFIEPMAVV NLNNELKELF IKEQEEIEKI
260 270 280 290 300
LAALSDKVAM NAAALEQDYE ILSELDFIFA KANLAKSYNG VAPDFNTDGH
310 320 330 340 350
INIRKGRHPL LDAKKVVPID VRLGEDYKQL IITGPNTGGK TVSLKTVGLL
360 370 380 390 400
TLMGQAGLHI PAADRSKLAI FEDVFADIGD EQSIEQSLST FSSHMTNIVK
410 420 430 440 450
ILEKADDRSL CLFDELCSGT DPTEGAALAI SILNRLHQYG AITMATTHYS
460 470 480 490 500
ELKVYALSTD GVENACCEFN VETLSPTYRL LIGIPGKSNA FAISSKLGLD
510 520 530 540 550
ENIIEDAKSR INDNDLDFED LIASLESQRQ TIEKEQLEIN SYKAEIEKLK
560 570 580 590 600
KQLEEKNERI DKSKDKILRE ANEEAYKILQ DAKELADKTI RNFNKYGQGQ
610 620 630 640 650
APMSQMEKER SALRDKMNDK EKKLSDIKKN TAKANHKAPK KLRIGDSVLV
660 670 680 690 700
LSLNLKGTVH TLPNAKGDLY VQMGILRSLV NINDLVLLND DVSPAKKYGG
710 720 730 740 750
SGSKIKMSKS LSVSSEINLI GKTTDEALAL LDKYLDDAYI AHLSSVRIVH
760 770 780 790
GKGTGALRKA VHGLLKRTKT IAEYHLGEFG EGDAGVTIAT FK
Length:792
Mass (Da):87,574
Last modified:July 28, 2009 - v1
Checksum:i4246F3B54A909D71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001107 Genomic DNA. Translation: ACR76644.1.
RefSeqiWP_012743671.1. NC_012781.1.

Genome annotation databases

EnsemblBacteriaiACR76644; ACR76644; EUBREC_2915.
KEGGiere:EUBREC_2915.
PATRICi21873795. VBIEubRec107985_2536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001107 Genomic DNA. Translation: ACR76644.1.
RefSeqiWP_012743671.1. NC_012781.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR76644; ACR76644; EUBREC_2915.
KEGGiere:EUBREC_2915.
PATRICi21873795. VBIEubRec107985_2536.

Phylogenomic databases

eggNOGiCOG1193.
HOGENOMiHOG000135096.
KOiK07456.
OMAiHMTHIVE.
OrthoDBiEOG6P5ZC4.

Enzyme and pathway databases

BioCyciEREC515619:GHMX-2904-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00092. MutS2.
InterProiIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamiPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFiPIRSF005814. MutS_YshD. 1 hit.
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01069. mutS2. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33656 / VPI 0990.

Entry informationi

Entry nameiMUTS2_EUBR3
AccessioniPrimary (citable) accession number: C4ZI07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: July 22, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.