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C4ZI07

- MUTS2_EUBR3

UniProt

C4ZI07 - MUTS2_EUBR3

Protein

Endonuclease MutS2

Gene

mutS2

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi334 – 3418ATPUniRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. endonuclease activity Source: UniProtKB-HAMAP
    4. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: InterPro
    2. negative regulation of DNA recombination Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEREC515619:GHMX-2904-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
    Gene namesi
    Name:mutS2UniRule annotation
    Ordered Locus Names:EUBREC_2915
    OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
    Taxonomic identifieri515619 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001477: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 792792Endonuclease MutS2PRO_1000202680Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi515619.EUBREC_2915.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini717 – 79276SmrUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation
    Contains 1 Smr domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1193.
    HOGENOMiHOG000135096.
    KOiK07456.
    OMAiFGGIVHD.
    OrthoDBiEOG6P5ZC4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00092. MutS2.
    InterProiIPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view]
    PANTHERiPTHR11361:SF14. PTHR11361:SF14. 1 hit.
    PfamiPF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005814. MutS_YshD. 1 hit.
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01069. mutS2. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4ZI07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKKVYKTLE YNKILTMLSS YAACDETKKR CLSLEPITDL YEIRHLQTTT    50
    ADALSRLYKD SGVSFVGIHN VHASLKRLDI GGALNTTELL RICSLLEVAK 100
    RVKAYGRSAM DNEKQDSLSG LFAGIEPVSA LCDEIKRCIL SEEEIADDAS 150
    PELFKIRKSI RGMNDRIHAQ LTKLMNNSTT RTYLQDAVVT MRDGRYCLPV 200
    KAEAKGNVPG MMHDQSSTGS TLFIEPMAVV NLNNELKELF IKEQEEIEKI 250
    LAALSDKVAM NAAALEQDYE ILSELDFIFA KANLAKSYNG VAPDFNTDGH 300
    INIRKGRHPL LDAKKVVPID VRLGEDYKQL IITGPNTGGK TVSLKTVGLL 350
    TLMGQAGLHI PAADRSKLAI FEDVFADIGD EQSIEQSLST FSSHMTNIVK 400
    ILEKADDRSL CLFDELCSGT DPTEGAALAI SILNRLHQYG AITMATTHYS 450
    ELKVYALSTD GVENACCEFN VETLSPTYRL LIGIPGKSNA FAISSKLGLD 500
    ENIIEDAKSR INDNDLDFED LIASLESQRQ TIEKEQLEIN SYKAEIEKLK 550
    KQLEEKNERI DKSKDKILRE ANEEAYKILQ DAKELADKTI RNFNKYGQGQ 600
    APMSQMEKER SALRDKMNDK EKKLSDIKKN TAKANHKAPK KLRIGDSVLV 650
    LSLNLKGTVH TLPNAKGDLY VQMGILRSLV NINDLVLLND DVSPAKKYGG 700
    SGSKIKMSKS LSVSSEINLI GKTTDEALAL LDKYLDDAYI AHLSSVRIVH 750
    GKGTGALRKA VHGLLKRTKT IAEYHLGEFG EGDAGVTIAT FK 792
    Length:792
    Mass (Da):87,574
    Last modified:July 28, 2009 - v1
    Checksum:i4246F3B54A909D71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR76644.1.
    RefSeqiWP_012743671.1. NC_012781.1.
    YP_002938778.1. NC_012781.1.

    Genome annotation databases

    EnsemblBacteriaiACR76644; ACR76644; EUBREC_2915.
    GeneIDi7963414.
    KEGGiere:EUBREC_2915.
    PATRICi21873795. VBIEubRec107985_2536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR76644.1 .
    RefSeqi WP_012743671.1. NC_012781.1.
    YP_002938778.1. NC_012781.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515619.EUBREC_2915.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR76644 ; ACR76644 ; EUBREC_2915 .
    GeneIDi 7963414.
    KEGGi ere:EUBREC_2915.
    PATRICi 21873795. VBIEubRec107985_2536.

    Phylogenomic databases

    eggNOGi COG1193.
    HOGENOMi HOG000135096.
    KOi K07456.
    OMAi FGGIVHD.
    OrthoDBi EOG6P5ZC4.

    Enzyme and pathway databases

    BioCyci EREC515619:GHMX-2904-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00092. MutS2.
    InterProi IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR005747. MutS2.
    IPR027417. P-loop_NTPase.
    IPR002625. Smr/MutS2_C.
    [Graphical view ]
    PANTHERi PTHR11361:SF14. PTHR11361:SF14. 1 hit.
    Pfami PF05192. MutS_III. 1 hit.
    PF00488. MutS_V. 1 hit.
    PF01713. Smr. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005814. MutS_YshD. 1 hit.
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01069. mutS2. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    PS50828. SMR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33656 / VPI 0990.

    Entry informationi

    Entry nameiMUTS2_EUBR3
    AccessioniPrimary (citable) accession number: C4ZI07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3