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C4ZI07 (MUTS2_EUBR3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endonuclease MutS2

EC=3.1.-.-
Gene names
Name:mutS2
Ordered Locus Names:EUBREC_2915
OrganismEubacterium rectale (strain ATCC 33656 / VPI 0990) [Complete proteome] [HAMAP]
Taxonomic identifier515619 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium

Protein attributes

Sequence length792 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity By similarity. HAMAP-Rule MF_00092

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00092

Sequence similarities

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.

Contains 1 Smr domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 792792Endonuclease MutS2 HAMAP-Rule MF_00092
PRO_1000202680

Regions

Domain717 – 79276Smr
Nucleotide binding334 – 3418ATP Potential

Sequences

Sequence LengthMass (Da)Tools
C4ZI07 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 4246F3B54A909D71

FASTA79287,574
        10         20         30         40         50         60 
MNKKVYKTLE YNKILTMLSS YAACDETKKR CLSLEPITDL YEIRHLQTTT ADALSRLYKD 

        70         80         90        100        110        120 
SGVSFVGIHN VHASLKRLDI GGALNTTELL RICSLLEVAK RVKAYGRSAM DNEKQDSLSG 

       130        140        150        160        170        180 
LFAGIEPVSA LCDEIKRCIL SEEEIADDAS PELFKIRKSI RGMNDRIHAQ LTKLMNNSTT 

       190        200        210        220        230        240 
RTYLQDAVVT MRDGRYCLPV KAEAKGNVPG MMHDQSSTGS TLFIEPMAVV NLNNELKELF 

       250        260        270        280        290        300 
IKEQEEIEKI LAALSDKVAM NAAALEQDYE ILSELDFIFA KANLAKSYNG VAPDFNTDGH 

       310        320        330        340        350        360 
INIRKGRHPL LDAKKVVPID VRLGEDYKQL IITGPNTGGK TVSLKTVGLL TLMGQAGLHI 

       370        380        390        400        410        420 
PAADRSKLAI FEDVFADIGD EQSIEQSLST FSSHMTNIVK ILEKADDRSL CLFDELCSGT 

       430        440        450        460        470        480 
DPTEGAALAI SILNRLHQYG AITMATTHYS ELKVYALSTD GVENACCEFN VETLSPTYRL 

       490        500        510        520        530        540 
LIGIPGKSNA FAISSKLGLD ENIIEDAKSR INDNDLDFED LIASLESQRQ TIEKEQLEIN 

       550        560        570        580        590        600 
SYKAEIEKLK KQLEEKNERI DKSKDKILRE ANEEAYKILQ DAKELADKTI RNFNKYGQGQ 

       610        620        630        640        650        660 
APMSQMEKER SALRDKMNDK EKKLSDIKKN TAKANHKAPK KLRIGDSVLV LSLNLKGTVH 

       670        680        690        700        710        720 
TLPNAKGDLY VQMGILRSLV NINDLVLLND DVSPAKKYGG SGSKIKMSKS LSVSSEINLI 

       730        740        750        760        770        780 
GKTTDEALAL LDKYLDDAYI AHLSSVRIVH GKGTGALRKA VHGLLKRTKT IAEYHLGEFG 

       790 
EGDAGVTIAT FK 

« Hide

References

[1]"Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla."
Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S., Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L., Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C., Hettich R.L., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33656 / VPI 0990.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001107 Genomic DNA. Translation: ACR76644.1.
RefSeqYP_002938778.1. NC_012781.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515619.EUBREC_2915.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR76644; ACR76644; EUBREC_2915.
GeneID7963414.
KEGGere:EUBREC_2915.
PATRIC21873795. VBIEubRec107985_2536.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1193.
HOGENOMHOG000135096.
KOK07456.
OMAFGGIVHD.
OrthoDBEOG6P5ZC4.

Enzyme and pathway databases

BioCycEREC515619:GHMX-2904-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00092. MutS2.
InterProIPR000432. DNA_mismatch_repair_MutS_C.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR005747. MutS2.
IPR027417. P-loop_NTPase.
IPR002625. Smr/MutS2_C.
[Graphical view]
PANTHERPTHR11361:SF14. PTHR11361:SF14. 1 hit.
PfamPF05192. MutS_III. 1 hit.
PF00488. MutS_V. 1 hit.
PF01713. Smr. 1 hit.
[Graphical view]
PIRSFPIRSF005814. MutS_YshD. 1 hit.
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01069. mutS2. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
PS50828. SMR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS2_EUBR3
AccessionPrimary (citable) accession number: C4ZI07
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families