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C4ZH75

- PUR5_EUBR3

UniProt

C4ZH75 - PUR5_EUBR3

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEREC515619:GHMX-1119-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:EUBREC_1125
OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
Taxonomic identifieri515619 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001477: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515619.EUBREC_1125.

Structurei

3D structure databases

ProteinModelPortaliC4ZH75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4ZH75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYKNSGVDI EAGYKSVELM KKHVKETMRP EVLGGLGGFS GAFSLASIKD
60 70 80 90 100
MEDPVLLSGT DGCGTKVKLA FIMDKHDTIG IDAVAMCVND VACAGGEPLF
110 120 130 140 150
FLDYIACGKN YPEKIATIVS GVAEGCKQSG CALVGGETAE HPGLMPEDEY
160 170 180 190 200
DLAGFAVGVV DRKDIITGEG LKDGDVLIGM ASTGVHSNGF SLVRKIFKMD
210 220 230 240 250
KETLNTYHEE LGTTLGEALL APTRIYVKAL KAVKDAGVTV KACSHITGGG
260 270 280 290 300
FYENIPRMLI DGKRAVVEKN SYPVPPIFKM MAREGNVEEQ MMYNTYNMGL
310 320 330 340
GMIVAVDPAD VDKTMEAMKS AGDTPYVVGK IIDGEKGVDL V
Length:341
Mass (Da):36,348
Last modified:July 28, 2009 - v1
Checksum:i51B48053F7F94E19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR74887.1.
RefSeqiYP_002937021.1. NC_012781.1.

Genome annotation databases

EnsemblBacteriaiACR74887; ACR74887; EUBREC_1125.
GeneIDi7964138.
KEGGiere:EUBREC_1125.
PATRICi21870581. VBIEubRec107985_0954.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR74887.1 .
RefSeqi YP_002937021.1. NC_012781.1.

3D structure databases

ProteinModelPortali C4ZH75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515619.EUBREC_1125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR74887 ; ACR74887 ; EUBREC_1125 .
GeneIDi 7964138.
KEGGi ere:EUBREC_1125.
PATRICi 21870581. VBIEubRec107985_0954.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci EREC515619:GHMX-1119-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33656 / VPI 0990.

Entry informationi

Entry nameiPUR5_EUBR3
AccessioniPrimary (citable) accession number: C4ZH75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3