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C4ZH75

- PUR5_EUBR3

UniProt

C4ZH75 - PUR5_EUBR3

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEREC515619:GHMX-1119-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:EUBREC_1125
    OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
    Taxonomic identifieri515619 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001477: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212821Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515619.EUBREC_1125.

    Structurei

    3D structure databases

    ProteinModelPortaliC4ZH75.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229090.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4ZH75-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYKNSGVDI EAGYKSVELM KKHVKETMRP EVLGGLGGFS GAFSLASIKD    50
    MEDPVLLSGT DGCGTKVKLA FIMDKHDTIG IDAVAMCVND VACAGGEPLF 100
    FLDYIACGKN YPEKIATIVS GVAEGCKQSG CALVGGETAE HPGLMPEDEY 150
    DLAGFAVGVV DRKDIITGEG LKDGDVLIGM ASTGVHSNGF SLVRKIFKMD 200
    KETLNTYHEE LGTTLGEALL APTRIYVKAL KAVKDAGVTV KACSHITGGG 250
    FYENIPRMLI DGKRAVVEKN SYPVPPIFKM MAREGNVEEQ MMYNTYNMGL 300
    GMIVAVDPAD VDKTMEAMKS AGDTPYVVGK IIDGEKGVDL V 341
    Length:341
    Mass (Da):36,348
    Last modified:July 28, 2009 - v1
    Checksum:i51B48053F7F94E19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR74887.1.
    RefSeqiYP_002937021.1. NC_012781.1.

    Genome annotation databases

    EnsemblBacteriaiACR74887; ACR74887; EUBREC_1125.
    GeneIDi7964138.
    KEGGiere:EUBREC_1125.
    PATRICi21870581. VBIEubRec107985_0954.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR74887.1 .
    RefSeqi YP_002937021.1. NC_012781.1.

    3D structure databases

    ProteinModelPortali C4ZH75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515619.EUBREC_1125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR74887 ; ACR74887 ; EUBREC_1125 .
    GeneIDi 7964138.
    KEGGi ere:EUBREC_1125.
    PATRICi 21870581. VBIEubRec107985_0954.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229090.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci EREC515619:GHMX-1119-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33656 / VPI 0990.

    Entry informationi

    Entry nameiPUR5_EUBR3
    AccessioniPrimary (citable) accession number: C4ZH75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3