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C4ZBG8

- FTHS_EUBR3

UniProt

C4ZBG8 - FTHS_EUBR3

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, EUBREC_1958
Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEREC515619:GHMX-1950-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:EUBREC_1958
OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
Taxonomic identifieri515619 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001477: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000215436Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515619.EUBREC_1958.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4ZBG8-1 [UniParc]FASTAAdd to Basket

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MKTDIQIAQE ATMLPIKDVA ASIGIEEDDL ELYGKYKAKI SDELINRTKK    50
NPDGKLILVT AINPTPAGEG KTTTSVGLGE AFGRLGKKAL IALREPSLGP 100
CFGIKGGAAG GGYAQVVPME DLNLHFTGDF HAITSANNLL AALLDNHIQQ 150
GNELGIDPRQ IVWKRCMDMN DRVLRNIVVG LGSKMDGMVR EDHFVITVAS 200
EIMAILCLAD DMADLKKRLG RIIVAYTFDG KPVTADDLQA TGSMAALLKD 250
ALKPNLIQTL EHTPAIVHGG PFANIAHGCN SVRATKTALK LADYVITEAG 300
FGADLGAEKF FDIKCRMAGL KPDAVVLVAT IRALKYNGGV PKDELSSENL 350
DALKAGIVNL EKHIENLHKF GVPVVVTLNS FVTDTKAETD FVEQFCKERG 400
CEFALSEVWE KGGEGGIDLA NKVLETIEHK ESNFKVLYDD SLSLKEKIET 450
VAKEIYGADG VTYSPAAERE LKRITDLGMG DFPVCMAKTQ YSLSDDAKKL 500
GRPSGFKINV REVYASAGAG FVVAVNGSIM TMPGLSKKPA AYGIDVDDNG 550
VITGLF 556
Length:556
Mass (Da):59,751
Last modified:July 28, 2009 - v1
Checksum:i068E29AC30E75992
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR75700.1.
RefSeqiYP_002937834.1. NC_012781.1.

Genome annotation databases

EnsemblBacteriaiACR75700; ACR75700; EUBREC_1958.
GeneIDi7963911.
KEGGiere:EUBREC_1958.
PATRICi21872101. VBIEubRec107985_1698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001107 Genomic DNA. Translation: ACR75700.1 .
RefSeqi YP_002937834.1. NC_012781.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515619.EUBREC_1958.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR75700 ; ACR75700 ; EUBREC_1958 .
GeneIDi 7963911.
KEGGi ere:EUBREC_1958.
PATRICi 21872101. VBIEubRec107985_1698.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci EREC515619:GHMX-1950-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33656 / VPI 0990.

Entry informationi

Entry nameiFTHS_EUBR3
AccessioniPrimary (citable) accession number: C4ZBG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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