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C4ZBG8 (FTHS_EUBR3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:EUBREC_1958
OrganismEubacterium rectale (strain ATCC 33656 / VPI 0990) [Complete proteome] [HAMAP]
Taxonomic identifier515619 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000215436

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C4ZBG8 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 068E29AC30E75992

FASTA55659,751
        10         20         30         40         50         60 
MKTDIQIAQE ATMLPIKDVA ASIGIEEDDL ELYGKYKAKI SDELINRTKK NPDGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTTSVGLGE AFGRLGKKAL IALREPSLGP CFGIKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
DLNLHFTGDF HAITSANNLL AALLDNHIQQ GNELGIDPRQ IVWKRCMDMN DRVLRNIVVG 

       190        200        210        220        230        240 
LGSKMDGMVR EDHFVITVAS EIMAILCLAD DMADLKKRLG RIIVAYTFDG KPVTADDLQA 

       250        260        270        280        290        300 
TGSMAALLKD ALKPNLIQTL EHTPAIVHGG PFANIAHGCN SVRATKTALK LADYVITEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRMAGL KPDAVVLVAT IRALKYNGGV PKDELSSENL DALKAGIVNL 

       370        380        390        400        410        420 
EKHIENLHKF GVPVVVTLNS FVTDTKAETD FVEQFCKERG CEFALSEVWE KGGEGGIDLA 

       430        440        450        460        470        480 
NKVLETIEHK ESNFKVLYDD SLSLKEKIET VAKEIYGADG VTYSPAAERE LKRITDLGMG 

       490        500        510        520        530        540 
DFPVCMAKTQ YSLSDDAKKL GRPSGFKINV REVYASAGAG FVVAVNGSIM TMPGLSKKPA 

       550 
AYGIDVDDNG VITGLF 

« Hide

References

[1]"Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla."
Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S., Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L., Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C., Hettich R.L., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33656 / VPI 0990.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001107 Genomic DNA. Translation: ACR75700.1.
RefSeqYP_002937834.1. NC_012781.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515619.EUBREC_1958.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR75700; ACR75700; EUBREC_1958.
GeneID7963911.
KEGGere:EUBREC_1958.
PATRIC21872101. VBIEubRec107985_1698.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2402475.

Enzyme and pathway databases

BioCycEREC515619:GHMX-1950-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_EUBR3
AccessionPrimary (citable) accession number: C4ZBG8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways