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C4ZBG8

- FTHS_EUBR3

UniProt

C4ZBG8 - FTHS_EUBR3

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEREC515619:GHMX-1950-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:EUBREC_1958
    OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
    Taxonomic identifieri515619 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001477: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000215436Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515619.EUBREC_1958.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4ZBG8-1 [UniParc]FASTAAdd to Basket

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    MKTDIQIAQE ATMLPIKDVA ASIGIEEDDL ELYGKYKAKI SDELINRTKK    50
    NPDGKLILVT AINPTPAGEG KTTTSVGLGE AFGRLGKKAL IALREPSLGP 100
    CFGIKGGAAG GGYAQVVPME DLNLHFTGDF HAITSANNLL AALLDNHIQQ 150
    GNELGIDPRQ IVWKRCMDMN DRVLRNIVVG LGSKMDGMVR EDHFVITVAS 200
    EIMAILCLAD DMADLKKRLG RIIVAYTFDG KPVTADDLQA TGSMAALLKD 250
    ALKPNLIQTL EHTPAIVHGG PFANIAHGCN SVRATKTALK LADYVITEAG 300
    FGADLGAEKF FDIKCRMAGL KPDAVVLVAT IRALKYNGGV PKDELSSENL 350
    DALKAGIVNL EKHIENLHKF GVPVVVTLNS FVTDTKAETD FVEQFCKERG 400
    CEFALSEVWE KGGEGGIDLA NKVLETIEHK ESNFKVLYDD SLSLKEKIET 450
    VAKEIYGADG VTYSPAAERE LKRITDLGMG DFPVCMAKTQ YSLSDDAKKL 500
    GRPSGFKINV REVYASAGAG FVVAVNGSIM TMPGLSKKPA AYGIDVDDNG 550
    VITGLF 556
    Length:556
    Mass (Da):59,751
    Last modified:July 28, 2009 - v1
    Checksum:i068E29AC30E75992
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR75700.1.
    RefSeqiYP_002937834.1. NC_012781.1.

    Genome annotation databases

    EnsemblBacteriaiACR75700; ACR75700; EUBREC_1958.
    GeneIDi7963911.
    KEGGiere:EUBREC_1958.
    PATRICi21872101. VBIEubRec107985_1698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR75700.1 .
    RefSeqi YP_002937834.1. NC_012781.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515619.EUBREC_1958.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR75700 ; ACR75700 ; EUBREC_1958 .
    GeneIDi 7963911.
    KEGGi ere:EUBREC_1958.
    PATRICi 21872101. VBIEubRec107985_1698.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci EREC515619:GHMX-1950-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33656 / VPI 0990.

    Entry informationi

    Entry nameiFTHS_EUBR3
    AccessioniPrimary (citable) accession number: C4ZBG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3