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C4Z900

- DAPF_EUBR3

UniProt

C4Z900 - DAPF_EUBR3

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Eubacterium rectale (strain ATCC 33656 / VPI 0990)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111SubstrateUniRule annotation
    Binding sitei44 – 441SubstrateUniRule annotation
    Binding sitei62 – 621SubstrateUniRule annotation
    Active sitei71 – 711Proton donor/acceptorUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Sitei169 – 1691Important for catalytic activityUniRule annotation
    Binding sitei200 – 2001SubstrateUniRule annotation
    Sitei218 – 2181Important for catalytic activityUniRule annotation
    Active sitei227 – 2271Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciEREC515619:GHMX-1471-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:EUBREC_1477
    OrganismiEubacterium rectale (strain ATCC 33656 / VPI 0990)
    Taxonomic identifieri515619 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001477: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Diaminopimelate epimerasePRO_1000204060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 227

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi515619.EUBREC_1477.

    Structurei

    3D structure databases

    ProteinModelPortaliC4Z900.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni71 – 733Substrate bindingUniRule annotation
    Regioni218 – 2192Substrate bindingUniRule annotation
    Regioni228 – 2292Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiLIVEPPY.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4Z900-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFTKMHGCG NDYVYVNLFE EKLDDPARVS IYVSDRHFGI GSDGLITIGP    50
    SDKADFRMRI YNADGSEAEM CGNGIRCVAK YVYDHKLTDK TEISVETGAG 100
    IKYLTLYVEE NKVSQVRVDM GEPILTPGDI PVVKADGSAY SDDYRVIDEP 150
    ISAGNREWHM TCVSMGNPHA VVFVDDVAGF ELEKYGPLFE NHKMFPKRTN 200
    TEFVEILSRN EAKMRVWERG SAETWACGTG TCATVMACIL NKKTDNKVLV 250
    HLRGGDLTIE YIPETNHVFM TGPATEVFSG EIDII 285
    Length:285
    Mass (Da):31,778
    Last modified:July 28, 2009 - v1
    Checksum:i0C578469B0CE9E36
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR75231.1.
    RefSeqiWP_012742330.1. NC_012781.1.
    YP_002937365.1. NC_012781.1.

    Genome annotation databases

    EnsemblBacteriaiACR75231; ACR75231; EUBREC_1477.
    GeneIDi7963842.
    KEGGiere:EUBREC_1477.
    PATRICi21871185. VBIEubRec107985_1248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001107 Genomic DNA. Translation: ACR75231.1 .
    RefSeqi WP_012742330.1. NC_012781.1.
    YP_002937365.1. NC_012781.1.

    3D structure databases

    ProteinModelPortali C4Z900.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515619.EUBREC_1477.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR75231 ; ACR75231 ; EUBREC_1477 .
    GeneIDi 7963842.
    KEGGi ere:EUBREC_1477.
    PATRICi 21871185. VBIEubRec107985_1248.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi LIVEPPY.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci EREC515619:GHMX-1471-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33656 / VPI 0990.

    Entry informationi

    Entry nameiDAPF_EUBR3
    AccessioniPrimary (citable) accession number: C4Z900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3