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C4Z4D3

- C4Z4D3_EUBE2

UniProt

C4Z4D3 - C4Z4D3_EUBE2

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi329 – 3291Magnesium or manganese 1UniRule annotation
Metal bindingi342 – 3421Magnesium or manganese 1UniRule annotation
Metal bindingi342 – 3421Magnesium or manganese 2UniRule annotation
Metal bindingi344 – 3441Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi210 – 26152ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciEELI515620:GH1N-604-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:EUBELI_00604Imported
OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)Imported
Taxonomic identifieri515620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001476: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi515620.EUBELI_00604.

Structurei

3D structure databases

ProteinModelPortaliC4Z4D3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini184 – 375192ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011592.
KOiK01921.
OMAiANDTQYR.
OrthoDBiEOG6ND0KB.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4Z4D3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYINILQLS DNFTKNLQLT KNVNNYVDIV EKFRDKGEIM RIVVLAGGTS
60 70 80 90 100
TERDVSLVTG YRVCESLRRN GHEANMLDIF LGVDDSEVKT FFTEKNDLGE
110 120 130 140 150
LSDNLKKKTA DIPAEVKRRT EARESFFGRN VLELCKEADM VFMGLHGSNG
160 170 180 190 200
EDGKVQATFD LLGIRYTGTD YLSSAISMSK ELAKKVLVPE GIPMPKGVTL
210 220 230 240 250
HKGHKIEYVP FPCVVKPCCG GSSVGVSIAH NEKEFEDALD EAFSYEDTVL
260 270 280 290 300
VEEFVDGREF SVAVLDGKAL PVIEIEPLEG FYDYKNKYKA GSTKETCPAN
310 320 330 340 350
IPEDIASQMQ FWAEKCCQAA GVTTYARVDE LLDKNNNIFC LEINTLPGMT
360 370 380
DTSLIPQEAA AVGISYDELT EKIIEISLAK YE
Length:382
Mass (Da):42,463
Last modified:July 28, 2009 - v1
Checksum:iA59303CBBE1F7778
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR71617.1.
RefSeqiWP_012738853.1. NC_012778.1.
YP_002930064.1. NC_012778.1.

Genome annotation databases

EnsemblBacteriaiACR71617; ACR71617; EUBELI_00604.
GeneIDi7957478.
KEGGieel:EUBELI_00604.
PATRICi21864386. VBIEubEli113401_0558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR71617.1 .
RefSeqi WP_012738853.1. NC_012778.1.
YP_002930064.1. NC_012778.1.

3D structure databases

ProteinModelPortali C4Z4D3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515620.EUBELI_00604.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR71617 ; ACR71617 ; EUBELI_00604 .
GeneIDi 7957478.
KEGGi eel:EUBELI_00604.
PATRICi 21864386. VBIEubEli113401_0558.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011592.
KOi K01921.
OMAi ANDTQYR.
OrthoDBi EOG6ND0KB.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci EELI515620:GH1N-604-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27750 / VPI C15-48Imported.

Entry informationi

Entry nameiC4Z4D3_EUBE2
AccessioniPrimary (citable) accession number: C4Z4D3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3