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C4Z478

- PUR5_EUBE2

UniProt

C4Z478 - PUR5_EUBE2

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEELI515620:GH1N-549-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:EUBELI_00549
OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
Taxonomic identifieri515620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001476: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212820Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515620.EUBELI_00549.

Structurei

3D structure databases

ProteinModelPortaliC4Z478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

C4Z478-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYKKSGVDI EAGYKSVELM KEAVKSTMRE EVLGGIGGFS GAFSLAKIKE
60 70 80 90 100
MEEPVLLSGT DGCGTKVKLA FIMDKHDTIG IDAVAMCVND VVCAGGEPLF
110 120 130 140 150
FLDYIACGKN YPEKIATIVG GVAEGCRQSE CALIGGETAE HPGLMPQDEY
160 170 180 190 200
DLAGFAVGVV DKKDLITGEN IKPGDTLIGI ASSGVHSNGF SLVRSVFTMT
210 220 230 240 250
EESLNTYYDS LGKTLGEALL APTKIYVKTM KEIKKAGVKV KGCSHITGGG
260 270 280 290 300
FYENVPRMLP DGVKAVIKKD SYEVPPIFKM LAEDGNIEEH MMYNTFNMGI
310 320 330 340
GLVLAVDPAD VDTVMEAVKA AGETPYVIGS IEAGEKGVTL C
Length:341
Mass (Da):36,215
Last modified:July 28, 2009 - v1
Checksum:i9C97457875213CF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR71562.1.
RefSeqiWP_012738798.1. NC_012778.1.
YP_002930009.1. NC_012778.1.

Genome annotation databases

EnsemblBacteriaiACR71562; ACR71562; EUBELI_00549.
GeneIDi7958608.
KEGGieel:EUBELI_00549.
PATRICi21864282. VBIEubEli113401_0506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR71562.1 .
RefSeqi WP_012738798.1. NC_012778.1.
YP_002930009.1. NC_012778.1.

3D structure databases

ProteinModelPortali C4Z478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515620.EUBELI_00549.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR71562 ; ACR71562 ; EUBELI_00549 .
GeneIDi 7958608.
KEGGi eel:EUBELI_00549.
PATRICi 21864282. VBIEubEli113401_0506.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci EELI515620:GH1N-549-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27750 / VPI C15-48.

Entry informationi

Entry nameiPUR5_EUBE2
AccessioniPrimary (citable) accession number: C4Z478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3