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C4Z478

- PUR5_EUBE2

UniProt

C4Z478 - PUR5_EUBE2

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEELI515620:GH1N-549-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:EUBELI_00549
    OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
    Taxonomic identifieri515620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001476: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000212820Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515620.EUBELI_00549.

    Structurei

    3D structure databases

    ProteinModelPortaliC4Z478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4Z478-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYKKSGVDI EAGYKSVELM KEAVKSTMRE EVLGGIGGFS GAFSLAKIKE    50
    MEEPVLLSGT DGCGTKVKLA FIMDKHDTIG IDAVAMCVND VVCAGGEPLF 100
    FLDYIACGKN YPEKIATIVG GVAEGCRQSE CALIGGETAE HPGLMPQDEY 150
    DLAGFAVGVV DKKDLITGEN IKPGDTLIGI ASSGVHSNGF SLVRSVFTMT 200
    EESLNTYYDS LGKTLGEALL APTKIYVKTM KEIKKAGVKV KGCSHITGGG 250
    FYENVPRMLP DGVKAVIKKD SYEVPPIFKM LAEDGNIEEH MMYNTFNMGI 300
    GLVLAVDPAD VDTVMEAVKA AGETPYVIGS IEAGEKGVTL C 341
    Length:341
    Mass (Da):36,215
    Last modified:July 28, 2009 - v1
    Checksum:i9C97457875213CF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR71562.1.
    RefSeqiYP_002930009.1. NC_012778.1.

    Genome annotation databases

    EnsemblBacteriaiACR71562; ACR71562; EUBELI_00549.
    GeneIDi7958608.
    KEGGieel:EUBELI_00549.
    PATRICi21864282. VBIEubEli113401_0506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR71562.1 .
    RefSeqi YP_002930009.1. NC_012778.1.

    3D structure databases

    ProteinModelPortali C4Z478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515620.EUBELI_00549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR71562 ; ACR71562 ; EUBELI_00549 .
    GeneIDi 7958608.
    KEGGi eel:EUBELI_00549.
    PATRICi 21864282. VBIEubEli113401_0506.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci EELI515620:GH1N-549-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27750 / VPI C15-48.

    Entry informationi

    Entry nameiPUR5_EUBE2
    AccessioniPrimary (citable) accession number: C4Z478
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3