C4Z400 (C4Z400_EUBE2) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
S-ribosylhomocysteine lyase EMBL ACR72825.1

Gene names

Ordered Locus Names:

EUBELI_01836

Organism

Eubacterium eligens (strain ATCC 27750 / VPI C15-48) [Complete proteome] [HAMAP] EMBL ACR72825.1

Taxonomic identifier

515620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Eubacteriaceae › Eubacterium

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Lyase SAAS SAAS003815 EMBL ACR72825.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro lyase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C4Z400 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: A3A9C4740F4A17AF	FASTA	161	18,491
	10 20 30 40 50 60 MNKIASFTVN HLDLLTGVYV SRKDYIGDVC LTTFDLRFTR PNEEPPMDTP GIHSIEHLVA 70 80 90 100 110 120 TFLRNHAEWA EKTIYFGPMG CRTGFYVIFA GDLKSEDIIG ILREAADYVL NYDDNTPIPG 130 140 150 160 YSPRDCGNYL DNNLKLAKIY MRKFKEEVLD NPVEERLSYP Q

References

[1]

"Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla." Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S., Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L., Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C., Hettich R.L., Gordon J.I. Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009) [PubMed: 19321416] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001104 Genomic DNA. Translation: ACR72825.1.
RefSeq	YP_002931272.1. NC_012778.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C4Z400.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7957893.
GenomeReviews	Gene locus EUBELI_01836 in contig CP001104_GR.
KEGG	eel:EUBELI_01836.
PATRIC	21866750. VBIEubEli113401_1721.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TTFDIRM.
ProtClustDB	PRK02260.
Family and domain databases
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C4Z400_EUBE2

Accession

Primary (citable) accession number: C4Z400

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)