Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C4Z1V6

- FTHS_EUBE2

UniProt

C4Z1V6 - FTHS_EUBE2

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEELI515620:GH1N-1474-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:EUBELI_01474
    OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
    Taxonomic identifieri515620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001476: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000215435Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515620.EUBELI_01474.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4Z1V6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTDIEIAQE AVMEPIKNVA ARCGISEDDL ELYGKYKAKI SDEYINSVKG    50
    NEDGKLILVT AINPTPAGEG KTTITVGLGE AFGKLGKKAV IALREPSLGP 100
    CFGIKGGAAG GGYAQVVPME ELNLHFTGDF HAITSANNLC AALLDNHIQQ 150
    GNELGIDPRC VTWKRCMDMN DRVLRNIVVG LGSKVDGTVR EDHFVITVAS 200
    EIMAVLCLAT DMKDLKERLG KMVVAYNYQG QPVTAADIKA VGSMAALLKD 250
    ALKPNLIQTL EHTPALVHGG PFANIAHGCN SVRATKTALK MADYVITEAG 300
    FGADLGAEKF FDIKCRKSGL KPDAVVLVAT VRALKYNGGV PKTELSAENL 350
    DALKKGIVNL EKHIENLQKY GVPVVVTLNA FVSDTQAELD YIQKFCEDKG 400
    CEFALAKVWE KGGEGGIELA EKVLKTLETK KSNFHCLYET DQPVKAKIET 450
    IAKEIYGAGS VNYSAAANKQ IAQLEQLGFG NLPICMAKTQ YSLSDDPTLL 500
    GRPEGFEMNV REAYVSAGAG FIVVLTGSVM TMPGLSKSPA AYNIDVNDDG 550
    VITGLF 556
    Length:556
    Mass (Da):59,572
    Last modified:July 28, 2009 - v1
    Checksum:iEBFFC13081142678
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR72467.1.
    RefSeqiYP_002930914.1. NC_012778.1.

    Genome annotation databases

    EnsemblBacteriaiACR72467; ACR72467; EUBELI_01474.
    GeneIDi7957135.
    KEGGieel:EUBELI_01474.
    PATRICi21866086. VBIEubEli113401_1392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR72467.1 .
    RefSeqi YP_002930914.1. NC_012778.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515620.EUBELI_01474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR72467 ; ACR72467 ; EUBELI_01474 .
    GeneIDi 7957135.
    KEGGi eel:EUBELI_01474.
    PATRICi 21866086. VBIEubEli113401_1392.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci EELI515620:GH1N-1474-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27750 / VPI C15-48.

    Entry informationi

    Entry nameiFTHS_EUBE2
    AccessioniPrimary (citable) accession number: C4Z1V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3