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C4Z1V6

- FTHS_EUBE2

UniProt

C4Z1V6 - FTHS_EUBE2

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEELI515620:GH1N-1474-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:EUBELI_01474
OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
Taxonomic identifieri515620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001476: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000215435Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515620.EUBELI_01474.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4Z1V6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE AVMEPIKNVA ARCGISEDDL ELYGKYKAKI SDEYINSVKG
60 70 80 90 100
NEDGKLILVT AINPTPAGEG KTTITVGLGE AFGKLGKKAV IALREPSLGP
110 120 130 140 150
CFGIKGGAAG GGYAQVVPME ELNLHFTGDF HAITSANNLC AALLDNHIQQ
160 170 180 190 200
GNELGIDPRC VTWKRCMDMN DRVLRNIVVG LGSKVDGTVR EDHFVITVAS
210 220 230 240 250
EIMAVLCLAT DMKDLKERLG KMVVAYNYQG QPVTAADIKA VGSMAALLKD
260 270 280 290 300
ALKPNLIQTL EHTPALVHGG PFANIAHGCN SVRATKTALK MADYVITEAG
310 320 330 340 350
FGADLGAEKF FDIKCRKSGL KPDAVVLVAT VRALKYNGGV PKTELSAENL
360 370 380 390 400
DALKKGIVNL EKHIENLQKY GVPVVVTLNA FVSDTQAELD YIQKFCEDKG
410 420 430 440 450
CEFALAKVWE KGGEGGIELA EKVLKTLETK KSNFHCLYET DQPVKAKIET
460 470 480 490 500
IAKEIYGAGS VNYSAAANKQ IAQLEQLGFG NLPICMAKTQ YSLSDDPTLL
510 520 530 540 550
GRPEGFEMNV REAYVSAGAG FIVVLTGSVM TMPGLSKSPA AYNIDVNDDG

VITGLF
Length:556
Mass (Da):59,572
Last modified:July 28, 2009 - v1
Checksum:iEBFFC13081142678
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1.
RefSeqiWP_012739702.1. NC_012778.1.
YP_002930914.1. NC_012778.1.

Genome annotation databases

EnsemblBacteriaiACR72467; ACR72467; EUBELI_01474.
GeneIDi7957135.
KEGGieel:EUBELI_01474.
PATRICi21866086. VBIEubEli113401_1392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1 .
RefSeqi WP_012739702.1. NC_012778.1.
YP_002930914.1. NC_012778.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515620.EUBELI_01474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR72467 ; ACR72467 ; EUBELI_01474 .
GeneIDi 7957135.
KEGGi eel:EUBELI_01474.
PATRICi 21866086. VBIEubEli113401_1392.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci EELI515620:GH1N-1474-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27750 / VPI C15-48.

Entry informationi

Entry nameiFTHS_EUBE2
AccessioniPrimary (citable) accession number: C4Z1V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3