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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:EUBELI_01474
OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
Taxonomic identifieri515620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
Proteomesi
  • UP000001476 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002154351 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Interactioni

Protein-protein interaction databases

STRINGi515620.EUBELI_01474.

Structurei

3D structure databases

SMRiC4Z1V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLEVMNET.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C4Z1V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTDIEIAQE AVMEPIKNVA ARCGISEDDL ELYGKYKAKI SDEYINSVKG
60 70 80 90 100
NEDGKLILVT AINPTPAGEG KTTITVGLGE AFGKLGKKAV IALREPSLGP
110 120 130 140 150
CFGIKGGAAG GGYAQVVPME ELNLHFTGDF HAITSANNLC AALLDNHIQQ
160 170 180 190 200
GNELGIDPRC VTWKRCMDMN DRVLRNIVVG LGSKVDGTVR EDHFVITVAS
210 220 230 240 250
EIMAVLCLAT DMKDLKERLG KMVVAYNYQG QPVTAADIKA VGSMAALLKD
260 270 280 290 300
ALKPNLIQTL EHTPALVHGG PFANIAHGCN SVRATKTALK MADYVITEAG
310 320 330 340 350
FGADLGAEKF FDIKCRKSGL KPDAVVLVAT VRALKYNGGV PKTELSAENL
360 370 380 390 400
DALKKGIVNL EKHIENLQKY GVPVVVTLNA FVSDTQAELD YIQKFCEDKG
410 420 430 440 450
CEFALAKVWE KGGEGGIELA EKVLKTLETK KSNFHCLYET DQPVKAKIET
460 470 480 490 500
IAKEIYGAGS VNYSAAANKQ IAQLEQLGFG NLPICMAKTQ YSLSDDPTLL
510 520 530 540 550
GRPEGFEMNV REAYVSAGAG FIVVLTGSVM TMPGLSKSPA AYNIDVNDDG

VITGLF
Length:556
Mass (Da):59,572
Last modified:July 28, 2009 - v1
Checksum:iEBFFC13081142678
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1.
RefSeqiWP_012739702.1. NC_012778.1.

Genome annotation databases

EnsemblBacteriaiACR72467; ACR72467; EUBELI_01474.
KEGGieel:EUBELI_01474.
PATRICi21866086. VBIEubEli113401_1392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1.
RefSeqiWP_012739702.1. NC_012778.1.

3D structure databases

SMRiC4Z1V6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi515620.EUBELI_01474.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACR72467; ACR72467; EUBELI_01474.
KEGGieel:EUBELI_01474.
PATRICi21866086. VBIEubEli113401_1392.

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLEVMNET.
OrthoDBiPOG091H01S8.

Enzyme and pathway databases

UniPathwayiUPA00193.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFTHS_EUBE2
AccessioniPrimary (citable) accession number: C4Z1V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: March 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.