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C4Z1V6

- FTHS_EUBE2

UniProt

C4Z1V6 - FTHS_EUBE2

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, EUBELI_01474
Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEELI515620:GH1N-1474-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:EUBELI_01474
OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
Taxonomic identifieri515620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
ProteomesiUP000001476: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000215435Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi515620.EUBELI_01474.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4Z1V6-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQE AVMEPIKNVA ARCGISEDDL ELYGKYKAKI SDEYINSVKG    50
NEDGKLILVT AINPTPAGEG KTTITVGLGE AFGKLGKKAV IALREPSLGP 100
CFGIKGGAAG GGYAQVVPME ELNLHFTGDF HAITSANNLC AALLDNHIQQ 150
GNELGIDPRC VTWKRCMDMN DRVLRNIVVG LGSKVDGTVR EDHFVITVAS 200
EIMAVLCLAT DMKDLKERLG KMVVAYNYQG QPVTAADIKA VGSMAALLKD 250
ALKPNLIQTL EHTPALVHGG PFANIAHGCN SVRATKTALK MADYVITEAG 300
FGADLGAEKF FDIKCRKSGL KPDAVVLVAT VRALKYNGGV PKTELSAENL 350
DALKKGIVNL EKHIENLQKY GVPVVVTLNA FVSDTQAELD YIQKFCEDKG 400
CEFALAKVWE KGGEGGIELA EKVLKTLETK KSNFHCLYET DQPVKAKIET 450
IAKEIYGAGS VNYSAAANKQ IAQLEQLGFG NLPICMAKTQ YSLSDDPTLL 500
GRPEGFEMNV REAYVSAGAG FIVVLTGSVM TMPGLSKSPA AYNIDVNDDG 550
VITGLF 556
Length:556
Mass (Da):59,572
Last modified:July 28, 2009 - v1
Checksum:iEBFFC13081142678
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1.
RefSeqiYP_002930914.1. NC_012778.1.

Genome annotation databases

EnsemblBacteriaiACR72467; ACR72467; EUBELI_01474.
GeneIDi7957135.
KEGGieel:EUBELI_01474.
PATRICi21866086. VBIEubEli113401_1392.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001104 Genomic DNA. Translation: ACR72467.1 .
RefSeqi YP_002930914.1. NC_012778.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 515620.EUBELI_01474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACR72467 ; ACR72467 ; EUBELI_01474 .
GeneIDi 7957135.
KEGGi eel:EUBELI_01474.
PATRICi 21866086. VBIEubEli113401_1392.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci EELI515620:GH1N-1474-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27750 / VPI C15-48.

Entry informationi

Entry nameiFTHS_EUBE2
AccessioniPrimary (citable) accession number: C4Z1V6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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