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C4Z1V6 (FTHS_EUBE2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:EUBELI_01474
OrganismEubacterium eligens (strain ATCC 27750 / VPI C15-48) [Complete proteome] [HAMAP]
Taxonomic identifier515620 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000215435

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
C4Z1V6 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: EBFFC13081142678

FASTA55659,572
        10         20         30         40         50         60 
MKTDIEIAQE AVMEPIKNVA ARCGISEDDL ELYGKYKAKI SDEYINSVKG NEDGKLILVT 

        70         80         90        100        110        120 
AINPTPAGEG KTTITVGLGE AFGKLGKKAV IALREPSLGP CFGIKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
ELNLHFTGDF HAITSANNLC AALLDNHIQQ GNELGIDPRC VTWKRCMDMN DRVLRNIVVG 

       190        200        210        220        230        240 
LGSKVDGTVR EDHFVITVAS EIMAVLCLAT DMKDLKERLG KMVVAYNYQG QPVTAADIKA 

       250        260        270        280        290        300 
VGSMAALLKD ALKPNLIQTL EHTPALVHGG PFANIAHGCN SVRATKTALK MADYVITEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRKSGL KPDAVVLVAT VRALKYNGGV PKTELSAENL DALKKGIVNL 

       370        380        390        400        410        420 
EKHIENLQKY GVPVVVTLNA FVSDTQAELD YIQKFCEDKG CEFALAKVWE KGGEGGIELA 

       430        440        450        460        470        480 
EKVLKTLETK KSNFHCLYET DQPVKAKIET IAKEIYGAGS VNYSAAANKQ IAQLEQLGFG 

       490        500        510        520        530        540 
NLPICMAKTQ YSLSDDPTLL GRPEGFEMNV REAYVSAGAG FIVVLTGSVM TMPGLSKSPA 

       550 
AYNIDVNDDG VITGLF 

« Hide

References

[1]"Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla."
Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S., Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L., Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C., Hettich R.L., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27750 / VPI C15-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001104 Genomic DNA. Translation: ACR72467.1.
RefSeqYP_002930914.1. NC_012778.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING515620.EUBELI_01474.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACR72467; ACR72467; EUBELI_01474.
GeneID7957135.
KEGGeel:EUBELI_01474.
PATRIC21866086. VBIEubEli113401_1392.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMAIANSVSM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycEELI515620:GH1N-1474-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_EUBE2
AccessionPrimary (citable) accession number: C4Z1V6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways