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C4Z0G9

- NADK_EUBE2

UniProt

C4Z0G9 - NADK_EUBE2

Protein

NAD kinase

Gene

nadK

Organism
Eubacterium eligens (strain ATCC 27750 / VPI C15-48)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei68 – 681Proton acceptorUniRule annotation
    Binding sitei153 – 1531NADUniRule annotation
    Binding sitei172 – 1721NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 692NADUniRule annotation
    Nucleotide bindingi142 – 1432NADUniRule annotation
    Nucleotide bindingi183 – 1886NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciEELI515620:GH1N-1082-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:EUBELI_01082
    OrganismiEubacterium eligens (strain ATCC 27750 / VPI C15-48)
    Taxonomic identifieri515620 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesEubacteriaceaeEubacterium
    ProteomesiUP000001476: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293NAD kinasePRO_1000205415Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi515620.EUBELI_01082.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiDEIMIEM.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C4Z0G9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYFYIVTNR FKDPDGVNTR KIAHFLRSKG AECVCQIEQE KAFNKTGSYS    50
    DVRLVPNNTE CVIVLGGDGT LIQASRELSE KDIPFIGVNI GTLGYLTDTD 100
    MSSFEETLES LLRDDYEIDR RMMLDGCIYR GEERIFSDMA LNDVVINRNG 150
    ALRIIDFDIY VNGEYLNTYS ADGVIVSTAT GSTAYSLSAG GPIIQPTARL 200
    IMVTPICPHS LNQRSIIFAA DDEIMIEMKD NKSSSGRMTG SLKNDSARVA 250
    TFDGESFCEV VTGDRIVITQ SERISRFVKT SRISFLERIR NKM 293
    Length:293
    Mass (Da):32,753
    Last modified:July 28, 2009 - v1
    Checksum:iBACAB48BE34C1690
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR72082.1.
    RefSeqiYP_002930529.1. NC_012778.1.

    Genome annotation databases

    EnsemblBacteriaiACR72082; ACR72082; EUBELI_01082.
    GeneIDi7957389.
    KEGGieel:EUBELI_01082.
    PATRICi21865316. VBIEubEli113401_1012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001104 Genomic DNA. Translation: ACR72082.1 .
    RefSeqi YP_002930529.1. NC_012778.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 515620.EUBELI_01082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACR72082 ; ACR72082 ; EUBELI_01082 .
    GeneIDi 7957389.
    KEGGi eel:EUBELI_01082.
    PATRICi 21865316. VBIEubEli113401_1012.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi DEIMIEM.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci EELI515620:GH1N-1082-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27750 / VPI C15-48.

    Entry informationi

    Entry nameiNADK_EUBE2
    AccessioniPrimary (citable) accession number: C4Z0G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3