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C4YGK0 (ERK1_CANAW) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular signal-regulated kinase 1

Short name=ERK1
EC=2.7.11.24
Alternative name(s):
MAP kinase 1
Short name=MAPK 1
Gene names
Name:CEK1
Synonyms:ERK1
ORF Names:CAWG_03179
OrganismCandida albicans (strain WO-1) (Yeast) [Complete proteome]
Taxonomic identifier294748 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-226 and Tyr-228, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAA34343.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Extracellular signal-regulated kinase 1
PRO_0000413039

Regions

Domain66 – 369304Protein kinase
Nucleotide binding72 – 809ATP By similarity
Motif226 – 2283TXY
Compositional bias5 – 4945Ala/Gln-rich

Sites

Active site1901Proton acceptor By similarity
Binding site951ATP By similarity

Amino acid modifications

Modified residue2261Phosphothreonine By similarity
Modified residue2281Phosphotyrosine By similarity

Experimental info

Sequence conflict531S → SS in AAA34343. Ref.1

Sequences

Sequence LengthMass (Da)Tools
C4YGK0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 572857CFD5B00B67

FASTA41547,836
        10         20         30         40         50         60 
MNIDQHHQLQ QQHQQQMLQQ QAQAQAQAQA QAQQQQQAAA AAAAANAAAT TSSSPRQVSF 

        70         80         90        100        110        120 
NVSDHYQILE IVGEGAYGIV CSAIHKPSQQ KVAIKKIEPF ERSMLCLRTL RELKLLKHFN 

       130        140        150        160        170        180 
HENIISILAI QRPINYESFN EIYLIQELME TDLHRVIRTQ NLSDDHIQYF IYQTLRALKA 

       190        200        210        220        230        240 
MHSANVLHRD LKPSNLLLNS NCDLKICDFG LARSIASQED NYGFMTEYVA TRWYRAPEIM 

       250        260        270        280        290        300 
LTFQEYTTAI DVWSVGCILA EMLSGRPLFP GRDYHNQLWL IMEVLGTPNM EDYYNIKSKR 

       310        320        330        340        350        360 
AREYIRSLPF CKKIPFSELF ANTNNNTSTS NTGGRTNINP LALDLLEKLL IFNPAKRITV 

       370        380        390        400        410 
EDALKHPYLQ LYHDPNDEPI SDKIPEDFFD FDKMKDQLTI EDLKKLLYEE IMKPL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M76585 Genomic DNA. Translation: AAA34343.2. Different initiation.
CH672349 Genomic DNA. Translation: EEQ44882.1.
PIRA47211.

3D structure databases

ProteinModelPortalC4YGK0.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000233024.
OMAAIQRPIN.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERK1_CANAW
AccessionPrimary (citable) accession number: C4YGK0
Secondary accession number(s): P28869 expand/collapse secondary AC list , P87079, P87080, P87081, P87082, P87083, P87084, P87085, P87086, P87322
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families