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C4YFC7 (DUT_CANAW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT1
ORF Names:CAWG_01243
OrganismCandida albicans (strain WO-1) (Yeast) [Complete proteome]
Taxonomic identifier294748 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000413036

Regions

Region78 – 803Substrate binding By similarity
Region92 – 954Substrate binding By similarity
Region153 – 1542Substrate binding By similarity

Sites

Binding site1031Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
C4YFC7 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 982C016F1D31013A

FASTA15916,945
        10         20         30         40         50         60 
MTSEDQSLKK QKLESTQSLK VYLRSPKGKV PTKGSALAAG YDLYSAEAAT IPAHGQGLVS 

        70         80         90        100        110        120 
TDISIIVPIG TYGRVAPRSG LAVKHGISTG AGVIDADYRG EVKVVLFNHS EKDFEIKEGD 

       130        140        150 
RIAQLVLEQI VNADIKEISL EELDNTERGE GGFGSTGKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77925 Genomic DNA. Translation: CAA54897.1.
CH672346 Genomic DNA. Translation: EEQ43013.1.

3D structure databases

ProteinModelPortalC4YFC7.
SMRC4YFC7. Positions 25-159.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000028966.
OMAYSRIDFE.
OrthoDBEOG7T7H6C.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

Gene3D2.70.40.10. 1 hit.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 1 hit.
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_CANAW
AccessionPrimary (citable) accession number: C4YFC7
Secondary accession number(s): P43058, Q5A912
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways