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C4YA37

- LIPA_CLAL4

UniProt

C4YA37 - LIPA_CLAL4

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Protein
Lipoyl synthase, mitochondrial
Gene
CLUG_04975
Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi125 – 1251Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi131 – 1311Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi154 – 1541Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi157 – 1571Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, mitochondrial (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
ORF Names:CLUG_04975
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

Mitochondrion Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4444Mitochondrion Reviewed prediction
Add
BLAST
Chaini45 – 391347Lipoyl synthase, mitochondrialUniRule annotation
PRO_0000398262Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC4YA37.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

KOiK03644.
OrthoDBiEOG79KPR7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005963. Lipoyl_synth. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4YA37-1 [UniParc]FASTAAdd to Basket

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MVHPHLSRTK RTFFSHSSQM ISRHIRKTNS LAFVRALSAS ETAVTPRRKR    50
TVFTDELNKG PSFEDFVSGK AADVFVDPLE AARKDPEAKL PKWLKVPIPK 100
GRSFHSVKKD VRELKLATVC EEAKCPNISE CWGGKKSEAT ATIMLLGDTC 150
TRGCRFCSVK TSRTPAKPDP MEPENTAEAI SRWGLGYVVL TTVDRDDLAD 200
GGAAHLAETV RLIKQKAPQI LVEVLGGDFR GDLTSCDTLA VSGLDVYAHN 250
LETVEALTPH VRDRRATYRQ SLSILERAKQ AKPSLITKTS LMLGFGETDE 300
QIMQTLRDLR GIGCDVVTFG QYMRPTKRHM KVVEYVRPEK FDYWKEVALE 350
MGFLYVASGP LVRSSYKAGE AFIENVLRKR KHNVGDSPRL A 391
Length:391
Mass (Da):43,682
Last modified:July 28, 2009 - v1
Checksum:iEE362CDEE68AFA88
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408081 Genomic DNA. Translation: EEQ40847.1.
RefSeqiXP_002614960.1. XM_002614914.1.

Genome annotation databases

GeneIDi8495745.
KEGGiclu:CLUG_04975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408081 Genomic DNA. Translation: EEQ40847.1 .
RefSeqi XP_002614960.1. XM_002614914.1.

3D structure databases

ProteinModelPortali C4YA37.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8495745.
KEGGi clu:CLUG_04975.

Phylogenomic databases

KOi K03644.
OrthoDBi EOG79KPR7.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005963. Lipoyl_synth. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720.

Entry informationi

Entry nameiLIPA_CLAL4
AccessioniPrimary (citable) accession number: C4YA37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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