Uncharacterized protein

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functionⁱ

<p>Describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.</p><p><a href='../manual/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: InterPro
• histone methyltransferase activity (H3-K36 specific) Source: EnsemblFungi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• ascospore formation Source: EnsemblFungi
• DNA-templated transcription, termination Source: EnsemblFungi
• histone deacetylation Source: EnsemblFungi
• negative regulation of antisense RNA transcription Source: EnsemblFungi
• negative regulation of histone H3-K14 acetylation Source: EnsemblFungi
• negative regulation of histone H3-K9 acetylation Source: EnsemblFungi
• negative regulation of reciprocal meiotic recombination Source: EnsemblFungi
• positive regulation of histone acetylation Source: EnsemblFungi
• regulation of DNA-dependent DNA replication initiation Source: EnsemblFungi
• regulation of histone exchange Source: EnsemblFungi
• transcription elongation from RNA polymerase II promoter Source: EnsemblFungi

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Molecular functionⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Ligandⁱ

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• chromosome Source: InterPro
• cytosol Source: EnsemblFungi
• DNA-directed RNA polymerase II, holoenzyme Source: EnsemblFungi

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	43 – 99	57	AWSInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS51215			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	101 – 218	118	SETInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50280			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	225 – 241	17	Post-SETInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50868			Add BLAST
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	473 – 507	35	WWInterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS50020			Add BLAST

Coiled coil

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Denotes the positions of regions of coiled coil within the protein.</p><p><a href='../manual/coiled' target='_top'>More...</a></p>Coiled coili	579 – 613	35	Sequence analysis <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000256">More…</a></p> Automatic assertion according to rulesi SAM:Coils			Add BLAST

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSREASPVLF SDAPDKTAEA VTTFVPLAEC TYLTKQLGGS GQKETMTCDC 
        60         70         80         90        100
VEEWNEGKAQ NLACGEDSNC INRATSVECV NGSCTCGQNC QNQRFQKKQY 
       110        120        130        140        150
SSVKVIQTEK KGYGLVAQAD VPEGSFVYEY IGEVIDEKTF RARMLDYDRR 
       160        170        180        190        200
NLRHFYFMML TKDAFIDATE KGSLARFCNH SCSPNAYVDK WVVGDKLRMG 
       210        220        230        240        250
IFARRRILAG EEITFDYNVD RYGAQQQPCY CGSPNCMGWI GGKTQTDAAL 
       260        270        280        290        300
LLPDGISDAL GVTRQQEKAW LKQHKNNKSK ADKDKNDKSD SGVNDEFVRS 
       310        320        330        340        350
LEVEPVPLSD VNKVMGALMK VEDDSLVSKL VERLFLTEDA KVNTAIVRFH 
       360        370        380        390        400
GYKTLSKILK QYGTDDELSL RILSILRRWP TMTRNKIESS QIEDVVKQIS 
       410        420        430        440        450
STSENQDIQN LAAGLLSDWS KLEMAYRIPK NNDASAREAS TGSMSPMLGR 
       460        470        480        490        500
NARSESPRDN DAQATGVDLD DDDDLPEGWQ KAMDPNTNTV YYYHTGLGIS 
       510        520        530        540        550
KWERPSSAVP TGPKAPSAPQ KHKKAEKPRS KDTRPKDVRP KGPRPRNFSE 
       560        570        580        590        600
DEFTRLQEEK LQKQKEEQFN GVVEKQKLLQ DLILQSQREV EEKKRLEEKL 
       610        620        630        640        650
KQEKIEKYKE RRRKNEAARS SSSSSSSKVS IETLWTKTLA KYIPNMIKKY 
       660        670        680        690        700
EADIGHENIK GCARELVKIL AGKETKKAPD TKPPRELDNA KLKKLKEFSK 
       710 
SFMEKFLVKY RAKRAKA                                  

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ