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UniProtKB - C4Y9S1 (C4Y9S1_CLAL4)

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Protein

Histone-lysine N-methyltransferase

Gene

CLUG_05142

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:CLUG_05142Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Metschnikowiaceae › Clavispora ›
Proteomesi
  • UP000007703 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi306902.XP_002615127.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 99AWSInterPro annotationAdd BLAST57
Domaini101 – 218SETInterPro annotationAdd BLAST118
Domaini225 – 241Post-SETInterPro annotationAdd BLAST17
Domaini473 – 507WWInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili579 – 613Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
InParanoidiC4Y9S1.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C4Y9S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREASPVLF SDAPDKTAEA VTTFVPLAEC TYLTKQLGGS GQKETMTCDC 
        60         70         80         90        100
VEEWNEGKAQ NLACGEDSNC INRATSVECV NGSCTCGQNC QNQRFQKKQY 
       110        120        130        140        150
SSVKVIQTEK KGYGLVAQAD VPEGSFVYEY IGEVIDEKTF RARMLDYDRR 
       160        170        180        190        200
NLRHFYFMML TKDAFIDATE KGSLARFCNH SCSPNAYVDK WVVGDKLRMG 
       210        220        230        240        250
IFARRRILAG EEITFDYNVD RYGAQQQPCY CGSPNCMGWI GGKTQTDAAL 
       260        270        280        290        300
LLPDGISDAL GVTRQQEKAW LKQHKNNKSK ADKDKNDKSD SGVNDEFVRS 
       310        320        330        340        350
LEVEPVPLSD VNKVMGALMK VEDDSLVSKL VERLFLTEDA KVNTAIVRFH 
       360        370        380        390        400
GYKTLSKILK QYGTDDELSL RILSILRRWP TMTRNKIESS QIEDVVKQIS 
       410        420        430        440        450
STSENQDIQN LAAGLLSDWS KLEMAYRIPK NNDASAREAS TGSMSPMLGR 
       460        470        480        490        500
NARSESPRDN DAQATGVDLD DDDDLPEGWQ KAMDPNTNTV YYYHTGLGIS 
       510        520        530        540        550
KWERPSSAVP TGPKAPSAPQ KHKKAEKPRS KDTRPKDVRP KGPRPRNFSE 
       560        570        580        590        600
DEFTRLQEEK LQKQKEEQFN GVVEKQKLLQ DLILQSQREV EEKKRLEEKL 
       610        620        630        640        650
KQEKIEKYKE RRRKNEAARS SSSSSSSKVS IETLWTKTLA KYIPNMIKKY 
       660        670        680        690        700
EADIGHENIK GCARELVKIL AGKETKKAPD TKPPRELDNA KLKKLKEFSK 
       710 
SFMEKFLVKY RAKRAKA
Length:717
Mass (Da):81,172
Last modified:July 28, 2009 - v1
Checksum:iFD50168AD55AD78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41014.1.
RefSeqiXP_002615127.1. XM_002615081.1.

Genome annotation databases

EnsemblFungiiEEQ41014; EEQ41014; CLUG_05142.
GeneIDi8495410.
KEGGiclu:CLUG_05142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41014.1.
RefSeqiXP_002615127.1. XM_002615081.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi306902.XP_002615127.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEEQ41014; EEQ41014; CLUG_05142.
GeneIDi8495410.
KEGGiclu:CLUG_05142.

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
InParanoidiC4Y9S1.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC4Y9S1_CLAL4
AccessioniPrimary (citable) accession number: C4Y9S1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 10, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.