CLUG_05142

Functionⁱ

Catalytic activityⁱ

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functionⁱ

histone methyltransferase activity (H3-K36 specific) Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

DNA-templated transcription, elongation Source: InterPro
regulation of transcription, DNA-templated Source: InterPro

Complete GO annotation...

Keywordsⁱ

Molecular function	MethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
Ligand	S-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesⁱ	ORF Names:CLUG_05142Imported
Organismⁱ	Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifierⁱ	306902 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Metschnikowiaceae › Clavispora › Clavispora lusitaniae
Proteomesⁱ	UP000007703 Componentⁱ: Unassembled WGS sequence

Subcellular locationⁱ

Nucleus
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00574581

GO - Cellular componentⁱ

chromosome Source: InterPro
nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusSAAS annotation

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	306902.XP_002615127.1.

STRINGⁱ

306902.XP_002615127.1.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	43 – 99	AWSInterPro annotationAdd BLAST	57
Domainⁱ	101 – 218	SETInterPro annotationAdd BLAST	118
Domainⁱ	225 – 241	Post-SETInterPro annotationAdd BLAST	17
Domainⁱ	473 – 507	WWInterPro annotationAdd BLAST	35

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	579 – 613	Sequence analysisAdd BLAST		35

Sequence similaritiesⁱ

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG4442. Eukaryota. COG2940. LUCA.
InParanoidⁱ	C4Y9S1.
KEGG Orthology (KO) More...KOⁱ	K11423.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3T9B.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006560. AWS_dom. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR017923. TFIIS_N. IPR001202. WW_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08711. Med26. 1 hit. PF00856. SET. 1 hit. PF08236. SRI. 1 hit. PF00397. WW. 1 hit.
SMARTⁱ	View protein in SMART SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS51568. SAM_MT43_SET2_1. 1 hit. PS50280. SET. 1 hit. PS50020. WW_DOMAIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

C4Y9S1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSREASPVLF SDAPDKTAEA VTTFVPLAEC TYLTKQLGGS GQKETMTCDC 
        60         70         80         90        100
VEEWNEGKAQ NLACGEDSNC INRATSVECV NGSCTCGQNC QNQRFQKKQY 
       110        120        130        140        150
SSVKVIQTEK KGYGLVAQAD VPEGSFVYEY IGEVIDEKTF RARMLDYDRR 
       160        170        180        190        200
NLRHFYFMML TKDAFIDATE KGSLARFCNH SCSPNAYVDK WVVGDKLRMG 
       210        220        230        240        250
IFARRRILAG EEITFDYNVD RYGAQQQPCY CGSPNCMGWI GGKTQTDAAL 
       260        270        280        290        300
LLPDGISDAL GVTRQQEKAW LKQHKNNKSK ADKDKNDKSD SGVNDEFVRS 
       310        320        330        340        350
LEVEPVPLSD VNKVMGALMK VEDDSLVSKL VERLFLTEDA KVNTAIVRFH 
       360        370        380        390        400
GYKTLSKILK QYGTDDELSL RILSILRRWP TMTRNKIESS QIEDVVKQIS 
       410        420        430        440        450
STSENQDIQN LAAGLLSDWS KLEMAYRIPK NNDASAREAS TGSMSPMLGR 
       460        470        480        490        500
NARSESPRDN DAQATGVDLD DDDDLPEGWQ KAMDPNTNTV YYYHTGLGIS 
       510        520        530        540        550
KWERPSSAVP TGPKAPSAPQ KHKKAEKPRS KDTRPKDVRP KGPRPRNFSE 
       560        570        580        590        600
DEFTRLQEEK LQKQKEEQFN GVVEKQKLLQ DLILQSQREV EEKKRLEEKL 
       610        620        630        640        650
KQEKIEKYKE RRRKNEAARS SSSSSSSKVS IETLWTKTLA KYIPNMIKKY 
       660        670        680        690        700
EADIGHENIK GCARELVKIL AGKETKKAPD TKPPRELDNA KLKKLKEFSK 
       710 
SFMEKFLVKY RAKRAKA

Length:717

Mass (Da):81,172

Last modified:July 28, 2009 - v1

Checksum:ⁱFD50168AD55AD78B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH408081 Genomic DNA. Translation: EEQ41014.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_002615127.1. XM_002615081.1.

Genome annotation databases

EnsemblFungiⁱ	EEQ41014; EEQ41014; CLUG_05142.
GeneIDⁱ	8495410.
KEGGⁱ	clu:CLUG_05142.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH408081 Genomic DNA. Translation: EEQ41014.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_002615127.1. XM_002615081.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	306902.XP_002615127.1.

STRINGⁱ

306902.XP_002615127.1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	EEQ41014; EEQ41014; CLUG_05142.
GeneIDⁱ	8495410.
KEGGⁱ	clu:CLUG_05142.

Phylogenomic databases

eggNOGⁱ	KOG4442. Eukaryota. COG2940. LUCA.
InParanoidⁱ	C4Y9S1.
KEGG Orthology (KO) More...KOⁱ	K11423.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3T9B.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006560. AWS_dom. IPR025788. Hist-Lys_N-MeTrfase_SET2_fun. IPR003616. Post-SET_dom. IPR001214. SET_dom. IPR013257. SRI. IPR017923. TFIIS_N. IPR001202. WW_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08711. Med26. 1 hit. PF00856. SET. 1 hit. PF08236. SRI. 1 hit. PF00397. WW. 1 hit.
SMARTⁱ	View protein in SMART SM00570. AWS. 1 hit. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. SM00456. WW. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51215. AWS. 1 hit. PS50868. POST_SET. 1 hit. PS51568. SAM_MT43_SET2_1. 1 hit. PS50280. SET. 1 hit. PS50020. WW_DOMAIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C4Y9S1_CLAL4
Accessionⁱ	C4Y9S1Primary (citable) accession number: C4Y9S1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 28, 2009
	Last sequence update:	July 28, 2009
	Last modified:	June 7, 2017
	This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - C4Y9S1 (C4Y9S1_CLAL4)

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Histone-lysine N-methyltransferase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Interactionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Domains and Repeats

Coiled coil

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - C4Y9S1 (C4Y9S1_CLAL4)

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Histone-lysine N-methyltransferase

CLUG_05142

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ