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Protein

Histone-lysine N-methyltransferase

Gene

CLUG_05142

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:CLUG_05142Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
Proteomesi
  • UP000007703 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi306902.XP_002615127.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 99AWSInterPro annotationAdd BLAST57
Domaini101 – 218SETInterPro annotationAdd BLAST118
Domaini225 – 241Post-SETInterPro annotationAdd BLAST17
Domaini473 – 507WWInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili579 – 613Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4442. Eukaryota.
COG2940. LUCA.
InParanoidiC4Y9S1.
KOiK11423.
OrthoDBiEOG092C3T9B.

Family and domain databases

CDDicd00201. WW. 1 hit.
InterProiView protein in InterPro
IPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
PfamiView protein in Pfam
PF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
SMARTiView protein in SMART
SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
PROSITEiView protein in PROSITE
PS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C4Y9S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSREASPVLF SDAPDKTAEA VTTFVPLAEC TYLTKQLGGS GQKETMTCDC
60 70 80 90 100
VEEWNEGKAQ NLACGEDSNC INRATSVECV NGSCTCGQNC QNQRFQKKQY
110 120 130 140 150
SSVKVIQTEK KGYGLVAQAD VPEGSFVYEY IGEVIDEKTF RARMLDYDRR
160 170 180 190 200
NLRHFYFMML TKDAFIDATE KGSLARFCNH SCSPNAYVDK WVVGDKLRMG
210 220 230 240 250
IFARRRILAG EEITFDYNVD RYGAQQQPCY CGSPNCMGWI GGKTQTDAAL
260 270 280 290 300
LLPDGISDAL GVTRQQEKAW LKQHKNNKSK ADKDKNDKSD SGVNDEFVRS
310 320 330 340 350
LEVEPVPLSD VNKVMGALMK VEDDSLVSKL VERLFLTEDA KVNTAIVRFH
360 370 380 390 400
GYKTLSKILK QYGTDDELSL RILSILRRWP TMTRNKIESS QIEDVVKQIS
410 420 430 440 450
STSENQDIQN LAAGLLSDWS KLEMAYRIPK NNDASAREAS TGSMSPMLGR
460 470 480 490 500
NARSESPRDN DAQATGVDLD DDDDLPEGWQ KAMDPNTNTV YYYHTGLGIS
510 520 530 540 550
KWERPSSAVP TGPKAPSAPQ KHKKAEKPRS KDTRPKDVRP KGPRPRNFSE
560 570 580 590 600
DEFTRLQEEK LQKQKEEQFN GVVEKQKLLQ DLILQSQREV EEKKRLEEKL
610 620 630 640 650
KQEKIEKYKE RRRKNEAARS SSSSSSSKVS IETLWTKTLA KYIPNMIKKY
660 670 680 690 700
EADIGHENIK GCARELVKIL AGKETKKAPD TKPPRELDNA KLKKLKEFSK
710
SFMEKFLVKY RAKRAKA
Length:717
Mass (Da):81,172
Last modified:July 28, 2009 - v1
Checksum:iFD50168AD55AD78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41014.1.
RefSeqiXP_002615127.1. XM_002615081.1.

Genome annotation databases

EnsemblFungiiEEQ41014; EEQ41014; CLUG_05142.
GeneIDi8495410.
KEGGiclu:CLUG_05142.

Entry informationi

Entry nameiC4Y9S1_CLAL4
AccessioniPrimary (citable) accession number: C4Y9S1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: August 30, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported