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Protein

Histone-lysine N-methyltransferase

Gene

CLUG_05142

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone methyltransferase activity (H3-K36 specific) Source: InterPro

GO - Biological processi

  1. DNA-templated transcription, elongation Source: InterPro
  2. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:CLUG_05142Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Phylogenomic databases

InParanoidiC4Y9S1.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4Y9S1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSREASPVLF SDAPDKTAEA VTTFVPLAEC TYLTKQLGGS GQKETMTCDC
60 70 80 90 100
VEEWNEGKAQ NLACGEDSNC INRATSVECV NGSCTCGQNC QNQRFQKKQY
110 120 130 140 150
SSVKVIQTEK KGYGLVAQAD VPEGSFVYEY IGEVIDEKTF RARMLDYDRR
160 170 180 190 200
NLRHFYFMML TKDAFIDATE KGSLARFCNH SCSPNAYVDK WVVGDKLRMG
210 220 230 240 250
IFARRRILAG EEITFDYNVD RYGAQQQPCY CGSPNCMGWI GGKTQTDAAL
260 270 280 290 300
LLPDGISDAL GVTRQQEKAW LKQHKNNKSK ADKDKNDKSD SGVNDEFVRS
310 320 330 340 350
LEVEPVPLSD VNKVMGALMK VEDDSLVSKL VERLFLTEDA KVNTAIVRFH
360 370 380 390 400
GYKTLSKILK QYGTDDELSL RILSILRRWP TMTRNKIESS QIEDVVKQIS
410 420 430 440 450
STSENQDIQN LAAGLLSDWS KLEMAYRIPK NNDASAREAS TGSMSPMLGR
460 470 480 490 500
NARSESPRDN DAQATGVDLD DDDDLPEGWQ KAMDPNTNTV YYYHTGLGIS
510 520 530 540 550
KWERPSSAVP TGPKAPSAPQ KHKKAEKPRS KDTRPKDVRP KGPRPRNFSE
560 570 580 590 600
DEFTRLQEEK LQKQKEEQFN GVVEKQKLLQ DLILQSQREV EEKKRLEEKL
610 620 630 640 650
KQEKIEKYKE RRRKNEAARS SSSSSSSKVS IETLWTKTLA KYIPNMIKKY
660 670 680 690 700
EADIGHENIK GCARELVKIL AGKETKKAPD TKPPRELDNA KLKKLKEFSK
710
SFMEKFLVKY RAKRAKA
Length:717
Mass (Da):81,172
Last modified:July 28, 2009 - v1
Checksum:iFD50168AD55AD78B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41014.1.
RefSeqiXP_002615127.1. XM_002615081.1.

Genome annotation databases

GeneIDi8495410.
KEGGiclu:CLUG_05142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41014.1.
RefSeqiXP_002615127.1. XM_002615081.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8495410.
KEGGiclu:CLUG_05142.

Phylogenomic databases

InParanoidiC4Y9S1.
KOiK11423.
OrthoDBiEOG7P8PH3.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR006560. AWS_dom.
IPR025788. Hist-Lys_N-MeTrfase_SET2_fun.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR013257. SRI.
IPR017923. TFIIS_N.
IPR001202. WW_dom.
[Graphical view]
PfamiPF08711. Med26. 1 hit.
PF00856. SET. 1 hit.
PF08236. SRI. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
SM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
SSF51045. SSF51045. 1 hit.
PROSITEiPS51215. AWS. 1 hit.
PS50868. POST_SET. 1 hit.
PS51568. SAM_MT43_SET2_1. 1 hit.
PS50280. SET. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720Imported.

Entry informationi

Entry nameiC4Y9S1_CLAL4
AccessioniPrimary (citable) accession number: C4Y9S1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.