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Protein

Malate dehydrogenase

Gene

CLUG_05128

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
ORF Names:CLUG_05128Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliC4Y9Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

InParanoidiC4Y9Q7.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4Y9Q7-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MVKVTVCGAA GGIGQPLSML LKLNPRVSRL ALYDIVNAVG VAADLSHINT
60 70 80 90 100
PAVVTGHQPA AKNDSSALVE ALQDSDIVVI PAGVPRKPGM SRADLFNINA
110 120 130 140 150
SIVRDLVAHA GRTCPNAAIL IISNPVNATV AIAAAVLKKL GVFNPRKLFG
160 170 180 190 200
VTTLDSVRAE TFLAQILDVP PASLRGKISV VGGHSGDTIV PLVHFDRALE
210 220 230 240 250
SKMKTVSASD YANFVHRVQY GGDEVVKAKI GAGSATLSMA YAGYRFASNV
260 270 280 290 300
LASLVDAAEY SAVPDSAYIY LDGAAGGAEI ATTLQDTPFF SVPVHLKKGE
310 320 330 340
VSSVVDPWHL VRTHEEKKMI AVALEGLEKS VSQGTNFVEG SKI
Length:343
Mass (Da):35,872
Last modified:July 28, 2009 - v1
Checksum:i0C174B42A59C1B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41000.1.
RefSeqiXP_002615113.1. XM_002615067.1.

Genome annotation databases

GeneIDi8495697.
KEGGiclu:CLUG_05128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408081 Genomic DNA. Translation: EEQ41000.1.
RefSeqiXP_002615113.1. XM_002615067.1.

3D structure databases

ProteinModelPortaliC4Y9Q7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8495697.
KEGGiclu:CLUG_05128.

Phylogenomic databases

InParanoidiC4Y9Q7.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720Imported.

Entry informationi

Entry nameiC4Y9Q7_CLAL4
AccessioniPrimary (citable) accession number: C4Y9Q7
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 4, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.