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C4Y8B4 (KEX1_CLAL4) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:CLUG_04442
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) [Complete proteome]
Taxonomic identifier306902 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora

Protein attributes

Sequence length654 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 654636Pheromone-processing carboxypeptidase KEX1
PRO_0000411913

Regions

Topological domain19 – 533515Lumenal Potential
Transmembrane534 – 55421Helical; Potential
Topological domain555 – 654100Cytoplasmic Potential

Sites

Active site1881 By similarity
Active site3951 By similarity
Active site4531 By similarity

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation4421N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
C4Y8B4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: B7713CDA55E005C4

FASTA65473,168
        10         20         30         40         50         60 
MIVRLFWLAV LWLALANANP LKRLNHVWSQ RGVAKDDFLV TSLPGLSENI ASDDVPLMFA 

        70         80         90        100        110        120 
GQLELYPENN THYFFWKFSD QKKEPEAANR TIFWLNGGPG CSSMDGALME AGPLRIGKDY 

       130        140        150        160        170        180 
KVQLNEGSWH RKGDVVFVDQ PAGTGFSYSR DYDVELYQIE YHFLQFLKKY FELFPEDAHN 

       190        200        210        220        230        240 
DIVLAGESYA GQYIPYIAHG ILERNKKLAD GESPYHLKGL AIGNGWISPN EQSLSFVPFA 

       250        260        270        280        290        300 
VQAGLVSQKD PGWKAILQQH MKCQDLVAAS HEDDTFGANS VVDKECEKVL NTILYELVDH 

       310        320        330        340        350        360 
SASQYEQCIN MYDYTLRDSF PSCGMNWPPD LSNVNHFLKS DEVMSSLNLV QQISWTECSE 

       370        380        390        400        410        420 
HVGKQMKARH SKPAITLFAD LLAEVEILLF HGNRDIICNY MGAESMIKKL HWGGQTGFSA 

       430        440        450        460        470        480 
DSPVLKWFHG DEEAGYVKSE RNLTFVNVFD ASHMVPFDKP EVSSALVDIL FKRFTVADDK 

       490        500        510        520        530        540 
LQTQAKKTNA NQNDSPSASE NDNESGRTSE SASSSPSESA ATETESHATR IVRLIQLAVI 

       550        560        570        580        590        600 
IILIWGLCAI YSTYRSKPTS IIKTKPSGRK KNVQWADLMP QEEPAPKGFL SKTLNKLSRT 

       610        620        630        640        650 
EHKYVPVDIE LGPTDGMDDA SSDSGPSNVG TAETPEFVIA SDDEENAHEH TEEH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408080 Genomic DNA. Translation: EEQ40314.1.
RefSeqXP_002615560.1. XM_002615514.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8496178.
KEGGclu:CLUG_04442.

Phylogenomic databases

KOK01288.
OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_CLAL4
AccessionPrimary (citable) accession number: C4Y8B4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries