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C4Y8B4

- KEX1_CLAL4

UniProt

C4Y8B4 - KEX1_CLAL4

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei188 – 1881By similarity
    Active sitei395 – 3951By similarity
    Active sitei453 – 4531By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CLUG_04442
    OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
    Taxonomic identifieri306902 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
    ProteomesiUP000007703: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 654636Pheromone-processing carboxypeptidase KEX1PRO_0000411913Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 533515LumenalSequence AnalysisAdd
    BLAST
    Topological domaini555 – 654100CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei534 – 55421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK01288.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C4Y8B4-1 [UniParc]FASTAAdd to Basket

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    MIVRLFWLAV LWLALANANP LKRLNHVWSQ RGVAKDDFLV TSLPGLSENI    50
    ASDDVPLMFA GQLELYPENN THYFFWKFSD QKKEPEAANR TIFWLNGGPG 100
    CSSMDGALME AGPLRIGKDY KVQLNEGSWH RKGDVVFVDQ PAGTGFSYSR 150
    DYDVELYQIE YHFLQFLKKY FELFPEDAHN DIVLAGESYA GQYIPYIAHG 200
    ILERNKKLAD GESPYHLKGL AIGNGWISPN EQSLSFVPFA VQAGLVSQKD 250
    PGWKAILQQH MKCQDLVAAS HEDDTFGANS VVDKECEKVL NTILYELVDH 300
    SASQYEQCIN MYDYTLRDSF PSCGMNWPPD LSNVNHFLKS DEVMSSLNLV 350
    QQISWTECSE HVGKQMKARH SKPAITLFAD LLAEVEILLF HGNRDIICNY 400
    MGAESMIKKL HWGGQTGFSA DSPVLKWFHG DEEAGYVKSE RNLTFVNVFD 450
    ASHMVPFDKP EVSSALVDIL FKRFTVADDK LQTQAKKTNA NQNDSPSASE 500
    NDNESGRTSE SASSSPSESA ATETESHATR IVRLIQLAVI IILIWGLCAI 550
    YSTYRSKPTS IIKTKPSGRK KNVQWADLMP QEEPAPKGFL SKTLNKLSRT 600
    EHKYVPVDIE LGPTDGMDDA SSDSGPSNVG TAETPEFVIA SDDEENAHEH 650
    TEEH 654
    Length:654
    Mass (Da):73,168
    Last modified:July 28, 2009 - v1
    Checksum:iB7713CDA55E005C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408080 Genomic DNA. Translation: EEQ40314.1.
    RefSeqiXP_002615560.1. XM_002615514.1.

    Genome annotation databases

    GeneIDi8496178.
    KEGGiclu:CLUG_04442.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408080 Genomic DNA. Translation: EEQ40314.1 .
    RefSeqi XP_002615560.1. XM_002615514.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8496178.
    KEGGi clu:CLUG_04442.

    Phylogenomic databases

    KOi K01288.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42720.

    Entry informationi

    Entry nameiKEX1_CLAL4
    AccessioniPrimary (citable) accession number: C4Y8B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3