Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C4Y8B4

- KEX1_CLAL4

UniProt

C4Y8B4 - KEX1_CLAL4

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881By similarity
Active sitei395 – 3951By similarity
Active sitei453 – 4531By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CLUG_04442
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 533515LumenalSequence AnalysisAdd
BLAST
Transmembranei534 – 55421HelicalSequence AnalysisAdd
BLAST
Topological domaini555 – 654100CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 654636Pheromone-processing carboxypeptidase KEX1PRO_0000411913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi503 – 5031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiC4Y8B4.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4Y8B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVRLFWLAV LWLALANANP LKRLNHVWSQ RGVAKDDFLV TSLPGLSENI
60 70 80 90 100
ASDDVPLMFA GQLELYPENN THYFFWKFSD QKKEPEAANR TIFWLNGGPG
110 120 130 140 150
CSSMDGALME AGPLRIGKDY KVQLNEGSWH RKGDVVFVDQ PAGTGFSYSR
160 170 180 190 200
DYDVELYQIE YHFLQFLKKY FELFPEDAHN DIVLAGESYA GQYIPYIAHG
210 220 230 240 250
ILERNKKLAD GESPYHLKGL AIGNGWISPN EQSLSFVPFA VQAGLVSQKD
260 270 280 290 300
PGWKAILQQH MKCQDLVAAS HEDDTFGANS VVDKECEKVL NTILYELVDH
310 320 330 340 350
SASQYEQCIN MYDYTLRDSF PSCGMNWPPD LSNVNHFLKS DEVMSSLNLV
360 370 380 390 400
QQISWTECSE HVGKQMKARH SKPAITLFAD LLAEVEILLF HGNRDIICNY
410 420 430 440 450
MGAESMIKKL HWGGQTGFSA DSPVLKWFHG DEEAGYVKSE RNLTFVNVFD
460 470 480 490 500
ASHMVPFDKP EVSSALVDIL FKRFTVADDK LQTQAKKTNA NQNDSPSASE
510 520 530 540 550
NDNESGRTSE SASSSPSESA ATETESHATR IVRLIQLAVI IILIWGLCAI
560 570 580 590 600
YSTYRSKPTS IIKTKPSGRK KNVQWADLMP QEEPAPKGFL SKTLNKLSRT
610 620 630 640 650
EHKYVPVDIE LGPTDGMDDA SSDSGPSNVG TAETPEFVIA SDDEENAHEH

TEEH
Length:654
Mass (Da):73,168
Last modified:July 28, 2009 - v1
Checksum:iB7713CDA55E005C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408080 Genomic DNA. Translation: EEQ40314.1.
RefSeqiXP_002615560.1. XM_002615514.1.

Genome annotation databases

GeneIDi8496178.
KEGGiclu:CLUG_04442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408080 Genomic DNA. Translation: EEQ40314.1 .
RefSeqi XP_002615560.1. XM_002615514.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8496178.
KEGGi clu:CLUG_04442.

Phylogenomic databases

InParanoidi C4Y8B4.
KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720.

Entry informationi

Entry nameiKEX1_CLAL4
AccessioniPrimary (citable) accession number: C4Y8B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3