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C4Y8B4

- KEX1_CLAL4

UniProt

C4Y8B4 - KEX1_CLAL4

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, CLUG_04442
Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881 By similarity
Active sitei395 – 3951 By similarity
Active sitei453 – 4531 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CLUG_04442
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 533515Lumenal Reviewed prediction
Add
BLAST
Transmembranei534 – 55421Helical; Reviewed prediction
Add
BLAST
Topological domaini555 – 654100Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 654636Pheromone-processing carboxypeptidase KEX1
PRO_0000411913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi442 – 4421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi503 – 5031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C4Y8B4-1 [UniParc]FASTAAdd to Basket

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MIVRLFWLAV LWLALANANP LKRLNHVWSQ RGVAKDDFLV TSLPGLSENI    50
ASDDVPLMFA GQLELYPENN THYFFWKFSD QKKEPEAANR TIFWLNGGPG 100
CSSMDGALME AGPLRIGKDY KVQLNEGSWH RKGDVVFVDQ PAGTGFSYSR 150
DYDVELYQIE YHFLQFLKKY FELFPEDAHN DIVLAGESYA GQYIPYIAHG 200
ILERNKKLAD GESPYHLKGL AIGNGWISPN EQSLSFVPFA VQAGLVSQKD 250
PGWKAILQQH MKCQDLVAAS HEDDTFGANS VVDKECEKVL NTILYELVDH 300
SASQYEQCIN MYDYTLRDSF PSCGMNWPPD LSNVNHFLKS DEVMSSLNLV 350
QQISWTECSE HVGKQMKARH SKPAITLFAD LLAEVEILLF HGNRDIICNY 400
MGAESMIKKL HWGGQTGFSA DSPVLKWFHG DEEAGYVKSE RNLTFVNVFD 450
ASHMVPFDKP EVSSALVDIL FKRFTVADDK LQTQAKKTNA NQNDSPSASE 500
NDNESGRTSE SASSSPSESA ATETESHATR IVRLIQLAVI IILIWGLCAI 550
YSTYRSKPTS IIKTKPSGRK KNVQWADLMP QEEPAPKGFL SKTLNKLSRT 600
EHKYVPVDIE LGPTDGMDDA SSDSGPSNVG TAETPEFVIA SDDEENAHEH 650
TEEH 654
Length:654
Mass (Da):73,168
Last modified:July 28, 2009 - v1
Checksum:iB7713CDA55E005C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408080 Genomic DNA. Translation: EEQ40314.1.
RefSeqiXP_002615560.1. XM_002615514.1.

Genome annotation databases

GeneIDi8496178.
KEGGiclu:CLUG_04442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408080 Genomic DNA. Translation: EEQ40314.1 .
RefSeqi XP_002615560.1. XM_002615514.1.

3D structure databases

ModBasei Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8496178.
KEGGi clu:CLUG_04442.

Phylogenomic databases

KOi K01288.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720.

Entry informationi

Entry nameiKEX1_CLAL4
AccessioniPrimary (citable) accession number: C4Y8B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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