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C4Y1F8

- MAP2_CLAL4

UniProt

C4Y1F8 - MAP2_CLAL4

Protein

Methionine aminopeptidase 2

Gene

MAP2

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

    Catalytic activityi

    Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei188 – 1881SubstrateUniRule annotation
    Metal bindingi208 – 2081Divalent metal cation 1UniRule annotation
    Metal bindingi219 – 2191Divalent metal cation 1UniRule annotation
    Metal bindingi219 – 2191Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi288 – 2881Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
    Binding sitei296 – 2961SubstrateUniRule annotation
    Metal bindingi321 – 3211Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi416 – 4161Divalent metal cation 1UniRule annotation
    Metal bindingi416 – 4161Divalent metal cation 2; catalyticUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-HAMAP
    2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein initiator methionine removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
    Short name:
    MAP 2UniRule annotation
    Short name:
    MetAP 2UniRule annotation
    Alternative name(s):
    Peptidase MUniRule annotation
    Gene namesi
    Name:MAP2UniRule annotation
    ORF Names:CLUG_02040
    OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
    Taxonomic identifieri306902 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
    ProteomesiUP000007703: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Methionine aminopeptidase 2PRO_0000407649Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliC4Y1F8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi66 – 7611Poly-LysAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01265.
    OrthoDBiEOG7BGHW3.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPiMF_03175. MetAP_2_euk.
    InterProiIPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    PRINTSiPR00599. MAPEPTIDASE.
    SUPFAMiSSF55920. SSF55920. 2 hits.
    TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.
    PROSITEiPS01202. MAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4Y1F8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAQTGTEM SPHHVTRTYK HENFLSFIST MSEKETVETT QEPKQVVEPT    50
    QELEELAIDG DQAAAKKKKS KKKKKKAVSL DKTYADGVFP EGQWMEYPLE 100
    VNSYRTTDEE KRYLDRQQNN HWQDFRKGAE VHRRVRQKAQ QQIKPGMTML 150
    EIADLIENSI RTYTGNDHTL KQGIGFPTGL SLNHVAAHYT PNSNDKVVLK 200
    YEDVMKVDIG VHVNGHIVDS AFTLTFDDKY DNLLTAVREA TYTGVKEAGI 250
    DVRLNDIGAA VQEVMESYEV ELDGKTYPVK CIRNLNGHNI GDYVIHSGKT 300
    VPIVANGDMT KMEEGETFAI ETFGTTGKGY VIPQGECSHY ALNQDIDGVK 350
    LPSERAKSLV KSIKDNFGTL PWCRRYLERA GEDKYLLALN QLVRAGVVED 400
    YPPLVDTSGS YTAQYEHTIL LHPHKKEVVS KGDDY 435
    Length:435
    Mass (Da):49,011
    Last modified:July 28, 2009 - v1
    Checksum:iAE5C51425D0A0E77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408077 Genomic DNA. Translation: EEQ37917.1.
    RefSeqiXP_002618581.1. XM_002618535.1.

    Genome annotation databases

    GeneIDi8498874.
    KEGGiclu:CLUG_02040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408077 Genomic DNA. Translation: EEQ37917.1 .
    RefSeqi XP_002618581.1. XM_002618535.1.

    3D structure databases

    ProteinModelPortali C4Y1F8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8498874.
    KEGGi clu:CLUG_02040.

    Phylogenomic databases

    KOi K01265.
    OrthoDBi EOG7BGHW3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPi MF_03175. MetAP_2_euk.
    InterProi IPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR018349. Pept_M24A_MAP2_BS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    PRINTSi PR00599. MAPEPTIDASE.
    SUPFAMi SSF55920. SSF55920. 2 hits.
    TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
    PROSITEi PS01202. MAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42720.

    Entry informationi

    Entry nameiMAP2_CLAL4
    AccessioniPrimary (citable) accession number: C4Y1F8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3