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C4XZ66

- C4XZ66_CLAL4

UniProt

C4XZ66 - C4XZ66_CLAL4

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
CLUG_01248
Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Enzyme regulationi

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3 By similarity.UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
ORF Names:CLUG_01248Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4XZ66-1 [UniParc]FASTAAdd to Basket

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MQCSSSVSTI MGSPKPESKD SLPLYRTVPM KVSSLLNSES GETVETMPIS     50
PDSLKVENEH SISPSIAKES TPASVKSDDY ESVSDELKKL TYTNLLRSHV 100
QKRLPDVDWD EIVRYVETLT LPTDFTKPEI ELIVSEWYKE GPVNHRMLEY 150
ECFARTRREI HSKICALEDL YGLKREELEC SQIIAMEVCN ELQLFLLSDI 200
KPMLPHMSTS NIAGMISKHY KYKNRWSDRE VEFISDCIER EESRESILEA 250
LVFRKPYEIR NKIDSVKRRL RRQSTPPIKK EPSPVVIAYE SKLSELMNSD 300
LTLTGIRSVM GSRNLNRVVQ DIQSRKKRDI ALPFTYPETE FLRHSLTNNM 350
PMADIMKELV IRSEEEVVAK LKTLQMACVR QKKFTNTVER LIYEAQWYMA 400
IADGESGGRP KRRTRNNVEL DDLRKEALTK KKKVERTLTP EEISEKQKRS 450
EIRTQRRIES LRRKAEENEL RKKKASMRGR KLRSTRKQEA ESRVAALIEE 500
ARWFQSVTGD GTCVKEGEKR KRRPVFHLVP EFKNRQQLKN AQKRLVEKKK 550
EVKKKRGRGR PRRTPSSDVD DSTSDSDSED DLEKLQHAID SDESDEFACV 600
SSFDPTDIIH DSLVPLSGRQ LFNNAITSGS VNPQPVSFSD DVSVMIQSNQ 650
YLPVNDTVAA KVIKDHIKSY KPLGASFPPL FTSDVNGSDV INSRNIIHIR 700
YLLYPQHTEQ FVLAAPKSNE LDPVFELQKI FQIHYALFFS HSSLIKDIIY 750
ENYCKSLERA VEEDNFSDFM TIIDQWNTLM LALSPYPVKF DPSIDINEAI 800
RLYLPSNYKF QPTVSDLKLD IFYYDVLSAG EIKDSDKETS IDRATSPLMR 850
PTGPIKDADS AIANIITRFR NLRPLSYPNA FIRSLQRVSE ISRFAIQQIL 900
LRAYTRIVSP NSRKLRSYKA FTAEVYGELL PSFVSEVLTK VDLKPEHSFY 950
DLGSGVGNTT FQAALEFGVK ESGGCELMNH ASELTSLQEI FMQKQLIVFG 1000
LKPLPLHFAL NQSFVNNPEV RSKCVGCDVL IVNNYLFDFP LNVEVGKLLY 1050
GMRPGSKIIS LKNFIPPRYK AGTEKTIFDY LKVEKHEMSD YLSVSWTANK 1100
VPYYISTVQE SVQQEYV 1117
Length:1,117
Mass (Da):128,265
Last modified:July 28, 2009 - v1
Checksum:i8E851EADEBAAB35D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408077 Genomic DNA. Translation: EEQ37125.1.
RefSeqiXP_002617789.1. XM_002617743.1.

Genome annotation databases

GeneIDi8498996.
KEGGiclu:CLUG_01248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH408077 Genomic DNA. Translation: EEQ37125.1 .
RefSeqi XP_002617789.1. XM_002617743.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8498996.
KEGGi clu:CLUG_01248.

Phylogenomic databases

KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720.

Entry informationi

Entry nameiC4XZ66_CLAL4
AccessioniPrimary (citable) accession number: C4XZ66
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3