Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

C4XZ66

- C4XZ66_CLAL4

UniProt

C4XZ66 - C4XZ66_CLAL4

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

CLUG_01248

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Enzyme regulationi

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:CLUG_01248Imported
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

InParanoidiC4XZ66.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4XZ66-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQCSSSVSTI MGSPKPESKD SLPLYRTVPM KVSSLLNSES GETVETMPIS
60 70 80 90 100
PDSLKVENEH SISPSIAKES TPASVKSDDY ESVSDELKKL TYTNLLRSHV
110 120 130 140 150
QKRLPDVDWD EIVRYVETLT LPTDFTKPEI ELIVSEWYKE GPVNHRMLEY
160 170 180 190 200
ECFARTRREI HSKICALEDL YGLKREELEC SQIIAMEVCN ELQLFLLSDI
210 220 230 240 250
KPMLPHMSTS NIAGMISKHY KYKNRWSDRE VEFISDCIER EESRESILEA
260 270 280 290 300
LVFRKPYEIR NKIDSVKRRL RRQSTPPIKK EPSPVVIAYE SKLSELMNSD
310 320 330 340 350
LTLTGIRSVM GSRNLNRVVQ DIQSRKKRDI ALPFTYPETE FLRHSLTNNM
360 370 380 390 400
PMADIMKELV IRSEEEVVAK LKTLQMACVR QKKFTNTVER LIYEAQWYMA
410 420 430 440 450
IADGESGGRP KRRTRNNVEL DDLRKEALTK KKKVERTLTP EEISEKQKRS
460 470 480 490 500
EIRTQRRIES LRRKAEENEL RKKKASMRGR KLRSTRKQEA ESRVAALIEE
510 520 530 540 550
ARWFQSVTGD GTCVKEGEKR KRRPVFHLVP EFKNRQQLKN AQKRLVEKKK
560 570 580 590 600
EVKKKRGRGR PRRTPSSDVD DSTSDSDSED DLEKLQHAID SDESDEFACV
610 620 630 640 650
SSFDPTDIIH DSLVPLSGRQ LFNNAITSGS VNPQPVSFSD DVSVMIQSNQ
660 670 680 690 700
YLPVNDTVAA KVIKDHIKSY KPLGASFPPL FTSDVNGSDV INSRNIIHIR
710 720 730 740 750
YLLYPQHTEQ FVLAAPKSNE LDPVFELQKI FQIHYALFFS HSSLIKDIIY
760 770 780 790 800
ENYCKSLERA VEEDNFSDFM TIIDQWNTLM LALSPYPVKF DPSIDINEAI
810 820 830 840 850
RLYLPSNYKF QPTVSDLKLD IFYYDVLSAG EIKDSDKETS IDRATSPLMR
860 870 880 890 900
PTGPIKDADS AIANIITRFR NLRPLSYPNA FIRSLQRVSE ISRFAIQQIL
910 920 930 940 950
LRAYTRIVSP NSRKLRSYKA FTAEVYGELL PSFVSEVLTK VDLKPEHSFY
960 970 980 990 1000
DLGSGVGNTT FQAALEFGVK ESGGCELMNH ASELTSLQEI FMQKQLIVFG
1010 1020 1030 1040 1050
LKPLPLHFAL NQSFVNNPEV RSKCVGCDVL IVNNYLFDFP LNVEVGKLLY
1060 1070 1080 1090 1100
GMRPGSKIIS LKNFIPPRYK AGTEKTIFDY LKVEKHEMSD YLSVSWTANK
1110
VPYYISTVQE SVQQEYV
Length:1,117
Mass (Da):128,265
Last modified:July 28, 2009 - v1
Checksum:i8E851EADEBAAB35D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408077 Genomic DNA. Translation: EEQ37125.1.
RefSeqiXP_002617789.1. XM_002617743.1.

Genome annotation databases

GeneIDi8498996.
KEGGiclu:CLUG_01248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408077 Genomic DNA. Translation: EEQ37125.1 .
RefSeqi XP_002617789.1. XM_002617743.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8498996.
KEGGi clu:CLUG_01248.

Phylogenomic databases

InParanoidi C4XZ66.
KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720Imported.

Entry informationi

Entry nameiC4XZ66_CLAL4
AccessioniPrimary (citable) accession number: C4XZ66
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3