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C4XZ66 (C4XZ66_CLAL4) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
ORF Names:CLUG_01248 EMBL EEQ37125.1
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) [Complete proteome] EMBL EEQ37125.1
Taxonomic identifier306902 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora

Protein attributes

Sequence length1117 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. RuleBase RU271113

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Enzyme regulation

Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3 By similarity. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C4XZ66 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 8E851EADEBAAB35D

FASTA1,117128,265
        10         20         30         40         50         60 
MQCSSSVSTI MGSPKPESKD SLPLYRTVPM KVSSLLNSES GETVETMPIS PDSLKVENEH 

        70         80         90        100        110        120 
SISPSIAKES TPASVKSDDY ESVSDELKKL TYTNLLRSHV QKRLPDVDWD EIVRYVETLT 

       130        140        150        160        170        180 
LPTDFTKPEI ELIVSEWYKE GPVNHRMLEY ECFARTRREI HSKICALEDL YGLKREELEC 

       190        200        210        220        230        240 
SQIIAMEVCN ELQLFLLSDI KPMLPHMSTS NIAGMISKHY KYKNRWSDRE VEFISDCIER 

       250        260        270        280        290        300 
EESRESILEA LVFRKPYEIR NKIDSVKRRL RRQSTPPIKK EPSPVVIAYE SKLSELMNSD 

       310        320        330        340        350        360 
LTLTGIRSVM GSRNLNRVVQ DIQSRKKRDI ALPFTYPETE FLRHSLTNNM PMADIMKELV 

       370        380        390        400        410        420 
IRSEEEVVAK LKTLQMACVR QKKFTNTVER LIYEAQWYMA IADGESGGRP KRRTRNNVEL 

       430        440        450        460        470        480 
DDLRKEALTK KKKVERTLTP EEISEKQKRS EIRTQRRIES LRRKAEENEL RKKKASMRGR 

       490        500        510        520        530        540 
KLRSTRKQEA ESRVAALIEE ARWFQSVTGD GTCVKEGEKR KRRPVFHLVP EFKNRQQLKN 

       550        560        570        580        590        600 
AQKRLVEKKK EVKKKRGRGR PRRTPSSDVD DSTSDSDSED DLEKLQHAID SDESDEFACV 

       610        620        630        640        650        660 
SSFDPTDIIH DSLVPLSGRQ LFNNAITSGS VNPQPVSFSD DVSVMIQSNQ YLPVNDTVAA 

       670        680        690        700        710        720 
KVIKDHIKSY KPLGASFPPL FTSDVNGSDV INSRNIIHIR YLLYPQHTEQ FVLAAPKSNE 

       730        740        750        760        770        780 
LDPVFELQKI FQIHYALFFS HSSLIKDIIY ENYCKSLERA VEEDNFSDFM TIIDQWNTLM 

       790        800        810        820        830        840 
LALSPYPVKF DPSIDINEAI RLYLPSNYKF QPTVSDLKLD IFYYDVLSAG EIKDSDKETS 

       850        860        870        880        890        900 
IDRATSPLMR PTGPIKDADS AIANIITRFR NLRPLSYPNA FIRSLQRVSE ISRFAIQQIL 

       910        920        930        940        950        960 
LRAYTRIVSP NSRKLRSYKA FTAEVYGELL PSFVSEVLTK VDLKPEHSFY DLGSGVGNTT 

       970        980        990       1000       1010       1020 
FQAALEFGVK ESGGCELMNH ASELTSLQEI FMQKQLIVFG LKPLPLHFAL NQSFVNNPEV 

      1030       1040       1050       1060       1070       1080 
RSKCVGCDVL IVNNYLFDFP LNVEVGKLLY GMRPGSKIIS LKNFIPPRYK AGTEKTIFDY 

      1090       1100       1110 
LKVEKHEMSD YLSVSWTANK VPYYISTVQE SVQQEYV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH408077 Genomic DNA. Translation: EEQ37125.1.
RefSeqXP_002617789.1. XM_002617743.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8498996.
KEGGclu:CLUG_01248.

Phylogenomic databases

KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4XZ66_CLAL4
AccessionPrimary (citable) accession number: C4XZ66
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 16, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)