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C4XZ66

- C4XZ66_CLAL4

UniProt

C4XZ66 - C4XZ66_CLAL4

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

CLUG_01248

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Enzyme regulationi

    Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.UniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:CLUG_01248Imported
    OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)Imported
    Taxonomic identifieri306902 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
    ProteomesiUP000007703: Unassembled WGS sequence

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4XZ66-1 [UniParc]FASTAAdd to Basket

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    MQCSSSVSTI MGSPKPESKD SLPLYRTVPM KVSSLLNSES GETVETMPIS     50
    PDSLKVENEH SISPSIAKES TPASVKSDDY ESVSDELKKL TYTNLLRSHV 100
    QKRLPDVDWD EIVRYVETLT LPTDFTKPEI ELIVSEWYKE GPVNHRMLEY 150
    ECFARTRREI HSKICALEDL YGLKREELEC SQIIAMEVCN ELQLFLLSDI 200
    KPMLPHMSTS NIAGMISKHY KYKNRWSDRE VEFISDCIER EESRESILEA 250
    LVFRKPYEIR NKIDSVKRRL RRQSTPPIKK EPSPVVIAYE SKLSELMNSD 300
    LTLTGIRSVM GSRNLNRVVQ DIQSRKKRDI ALPFTYPETE FLRHSLTNNM 350
    PMADIMKELV IRSEEEVVAK LKTLQMACVR QKKFTNTVER LIYEAQWYMA 400
    IADGESGGRP KRRTRNNVEL DDLRKEALTK KKKVERTLTP EEISEKQKRS 450
    EIRTQRRIES LRRKAEENEL RKKKASMRGR KLRSTRKQEA ESRVAALIEE 500
    ARWFQSVTGD GTCVKEGEKR KRRPVFHLVP EFKNRQQLKN AQKRLVEKKK 550
    EVKKKRGRGR PRRTPSSDVD DSTSDSDSED DLEKLQHAID SDESDEFACV 600
    SSFDPTDIIH DSLVPLSGRQ LFNNAITSGS VNPQPVSFSD DVSVMIQSNQ 650
    YLPVNDTVAA KVIKDHIKSY KPLGASFPPL FTSDVNGSDV INSRNIIHIR 700
    YLLYPQHTEQ FVLAAPKSNE LDPVFELQKI FQIHYALFFS HSSLIKDIIY 750
    ENYCKSLERA VEEDNFSDFM TIIDQWNTLM LALSPYPVKF DPSIDINEAI 800
    RLYLPSNYKF QPTVSDLKLD IFYYDVLSAG EIKDSDKETS IDRATSPLMR 850
    PTGPIKDADS AIANIITRFR NLRPLSYPNA FIRSLQRVSE ISRFAIQQIL 900
    LRAYTRIVSP NSRKLRSYKA FTAEVYGELL PSFVSEVLTK VDLKPEHSFY 950
    DLGSGVGNTT FQAALEFGVK ESGGCELMNH ASELTSLQEI FMQKQLIVFG 1000
    LKPLPLHFAL NQSFVNNPEV RSKCVGCDVL IVNNYLFDFP LNVEVGKLLY 1050
    GMRPGSKIIS LKNFIPPRYK AGTEKTIFDY LKVEKHEMSD YLSVSWTANK 1100
    VPYYISTVQE SVQQEYV 1117
    Length:1,117
    Mass (Da):128,265
    Last modified:July 28, 2009 - v1
    Checksum:i8E851EADEBAAB35D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408077 Genomic DNA. Translation: EEQ37125.1.
    RefSeqiXP_002617789.1. XM_002617743.1.

    Genome annotation databases

    GeneIDi8498996.
    KEGGiclu:CLUG_01248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH408077 Genomic DNA. Translation: EEQ37125.1 .
    RefSeqi XP_002617789.1. XM_002617743.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8498996.
    KEGGi clu:CLUG_01248.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42720Imported.

    Entry informationi

    Entry nameiC4XZ66_CLAL4
    AccessioniPrimary (citable) accession number: C4XZ66
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3