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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciDMAG573370:GHJL-2428-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:DMR_24020
OrganismiDesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
Taxonomic identifieri573370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009071 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalUniRule annotationAdd
BLAST
Transmembranei42 – 6221HelicalUniRule annotationAdd
BLAST
Transmembranei80 – 10021HelicalUniRule annotationAdd
BLAST
Transmembranei108 – 12821HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei181 – 20121HelicalUniRule annotationAdd
BLAST
Transmembranei220 – 24021HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Undecaprenyl-diphosphatasePRO_1000213149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi573370.DMR_24020.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

C4XT96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESLAAVVL GIVEGATEFL PVSSTGHLIL VGHLIGFTGE KADSFDVIIQ
60 70 80 90 100
LGAILAVVCL YWRRFWWLVS PKPHHAFSGI RGLWMLFLTS LPAGLIGLVA
110 120 130 140 150
RKSIKAYLFN PWSVALALSV GAVMIFLVEQ RKTRDRYYSL DEMTPGLALG
160 170 180 190 200
IGCFQCLSLW PGFSRSAATI MGGMLLGAKR SLAAEYSFIG AVPLMFAATL
210 220 230 240 250
YDFYKSAHLF SADDLGVLGI GFVVSFVSAL IAVKAFIVLV QRITLRPFAW
260
YRLALAAAVF FFWPK
Length:265
Mass (Da):28,995
Last modified:July 28, 2009 - v1
Checksum:i00664144C3B89293
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010904 Genomic DNA. Translation: BAH75893.1.
RefSeqiWP_015861073.1. NC_012796.1.

Genome annotation databases

EnsemblBacteriaiBAH75893; BAH75893; DMR_24020.
KEGGidma:DMR_24020.
PATRICi21751101. VBIDesMag26496_2317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP010904 Genomic DNA. Translation: BAH75893.1.
RefSeqiWP_015861073.1. NC_012796.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi573370.DMR_24020.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH75893; BAH75893; DMR_24020.
KEGGidma:DMR_24020.
PATRICi21751101. VBIDesMag26496_2317.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciDMAG573370:GHJL-2428-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria."
    Nakazawa H., Arakaki A., Narita-Yamada S., Yashiro I., Jinno K., Aoki N., Tsuruyama A., Okamura Y., Tanikawa S., Fujita N., Takeyama H., Matsunaga T.
    Genome Res. 19:1801-1808(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700980 / DSM 13731 / RS-1.

Entry informationi

Entry nameiUPPP_DESMR
AccessioniPrimary (citable) accession number: C4XT96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.