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C4XT96 (UPPP_DESMR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:DMR_24020
OrganismDesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) [Complete proteome] [HAMAP]
Taxonomic identifier573370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000213149

Regions

Transmembrane19 – 3921Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane108 – 12821Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane243 – 26321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
C4XT96 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 00664144C3B89293

FASTA26528,995
        10         20         30         40         50         60 
MTESLAAVVL GIVEGATEFL PVSSTGHLIL VGHLIGFTGE KADSFDVIIQ LGAILAVVCL 

        70         80         90        100        110        120 
YWRRFWWLVS PKPHHAFSGI RGLWMLFLTS LPAGLIGLVA RKSIKAYLFN PWSVALALSV 

       130        140        150        160        170        180 
GAVMIFLVEQ RKTRDRYYSL DEMTPGLALG IGCFQCLSLW PGFSRSAATI MGGMLLGAKR 

       190        200        210        220        230        240 
SLAAEYSFIG AVPLMFAATL YDFYKSAHLF SADDLGVLGI GFVVSFVSAL IAVKAFIVLV 

       250        260 
QRITLRPFAW YRLALAAAVF FFWPK 

« Hide

References

[1]"Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria."
Nakazawa H., Arakaki A., Narita-Yamada S., Yashiro I., Jinno K., Aoki N., Tsuruyama A., Okamura Y., Tanikawa S., Fujita N., Takeyama H., Matsunaga T.
Genome Res. 19:1801-1808(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700980 / DSM 13731 / RS-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP010904 Genomic DNA. Translation: BAH75893.1.
RefSeqYP_002953779.1. NC_012796.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING573370.DMR_24020.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH75893; BAH75893; DMR_24020.
GeneID7982027.
KEGGdma:DMR_24020.
PATRIC21751101. VBIDesMag26496_2317.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycDMAG573370:GHJL-2428-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DESMR
AccessionPrimary (citable) accession number: C4XT96
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families