C4XT96 (UPPP_DESMR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	DMR_24020

Organism

Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) [Complete proteome] [HAMAP]

Taxonomic identifier

573370 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio magneticus

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000213149
Regions
	Transmembrane	19 – 39	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	108 – 128	21	Helical; Potential
	Transmembrane	143 – 163	21	Helical; Potential
	Transmembrane	181 – 201	21	Helical; Potential
	Transmembrane	220 – 240	21	Helical; Potential
	Transmembrane	243 – 263	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	C4XT96 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 00664144C3B89293	FASTA	265	28,995
	10 20 30 40 50 60 MTESLAAVVL GIVEGATEFL PVSSTGHLIL VGHLIGFTGE KADSFDVIIQ LGAILAVVCL 70 80 90 100 110 120 YWRRFWWLVS PKPHHAFSGI RGLWMLFLTS LPAGLIGLVA RKSIKAYLFN PWSVALALSV 130 140 150 160 170 180 GAVMIFLVEQ RKTRDRYYSL DEMTPGLALG IGCFQCLSLW PGFSRSAATI MGGMLLGAKR 190 200 210 220 230 240 SLAAEYSFIG AVPLMFAATL YDFYKSAHLF SADDLGVLGI GFVVSFVSAL IAVKAFIVLV 250 260 QRITLRPFAW YRLALAAAVF FFWPK

References

[1]

"Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria." Nakazawa H., Arakaki A., Narita-Yamada S., Yashiro I., Jinno K., Aoki N., Tsuruyama A., Okamura Y., Tanikawa S., Fujita N., Takeyama H., Matsunaga T. Genome Res. 19:1801-1808(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700980 / DSM 13731 / RS-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP010904 Genomic DNA. Translation: BAH75893.1.
RefSeq	YP_002953779.1. NC_012796.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	573370.DMR_24020.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAH75893; BAH75893; DMR_24020.
GeneID	7982027.
KEGG	dma:DMR_24020.
PATRIC	21751101. VBIDesMag26496_2317.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	DMAG573370:GHJL-4728-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_DESMR

Accession

Primary (citable) accession number: C4XT96

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program