Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

C4XJB9 (GCSPA_DESMR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:DMR_31780
OrganismDesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) [Complete proteome] [HAMAP]
Taxonomic identifier573370 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000212660

Sequences

Sequence LengthMass (Da)Tools
C4XJB9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 6AB5AD920094553E

FASTA44347,975
        10         20         30         40         50         60 
MPYIPHTPAE IREMLDAVGA PDVDALFAEI PAALRPQSFD LAKGATEMAV RAAMEKLSAK 

        70         80         90        100        110        120 
NRTDLTSFLG GGFYDHYVPA ASDLLLSRGE FYTAYTPYQP EASQGTLQAI FEYQTAVCRL 

       130        140        150        160        170        180 
MDMECSNAGV YDGGTALYEA LMMAVRHTRR KKAVVSETVS PIYRIVLATY TKNLHLDLVV 

       190        200        210        220        230        240 
VPHKNGLDDF EALTAAVDGD TAAIVVQNPN FFGSVQDFTA LFDHAREKGA VSVISCYPVL 

       250        260        270        280        290        300 
QTVLKTPGAM GADIATAEGQ SLGLPLSFGG PYLGIMTCKK SLVRQMPGRI AGRTKDAAGR 

       310        320        330        340        350        360 
TGYVLTLQAR EQHIRRQKAT SNICSNQALC ALRALINLCL TGNEGLSRQA ARSIENANYA 

       370        380        390        400        410        420 
AWKLGAIPGV KLLNEAPFGN EFAAVFPVNA KQVARMLMDG GIVPGFPLGR YYQGLENALL 

       430        440 
ICCTEKHDRA DIDRLARRLE NAL 

« Hide

References

[1]"Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria."
Nakazawa H., Arakaki A., Narita-Yamada S., Yashiro I., Jinno K., Aoki N., Tsuruyama A., Okamura Y., Tanikawa S., Fujita N., Takeyama H., Matsunaga T.
Genome Res. 19:1801-1808(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700980 / DSM 13731 / RS-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP010904 Genomic DNA. Translation: BAH76669.1.
RefSeqYP_002954555.1. NC_012796.1.

3D structure databases

ProteinModelPortalC4XJB9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING573370.DMR_31780.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH76669; BAH76669; DMR_31780.
GeneID7980912.
KEGGdma:DMR_31780.
PATRIC21752601. VBIDesMag26496_3050.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycDMAG573370:GHJL-3221-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_DESMR
AccessionPrimary (citable) accession number: C4XJB9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families