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C4XIJ3

- THIM_DESMR

UniProt

C4XIJ3 - THIM_DESMR

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, DMR_30770
Organism
Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461Substrate; via amide nitrogen By similarity
Binding sitei122 – 1221ATP By similarity
Binding sitei168 – 1681ATP By similarity
Binding sitei195 – 1951Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDMAG573370:GHJL-3114-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:DMR_30770
OrganismiDesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1)
Taxonomic identifieri573370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000009071: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Hydroxyethylthiazole kinaseUniRule annotationPRO_1000204358Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi573370.DMR_30770.

Structurei

3D structure databases

ProteinModelPortaliC4XIJ3.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

C4XIJ3-1 [UniParc]FASTAAdd to Basket

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MPFAAAVFAD LARIRQNAPL VVNITNNVVT NATANALLAL GASPAMTHHP    50
ADAAELAALA GALVCNMGTP GGENIEAMLA AGGAANAGGV PVVFDPVAAG 100
VTSRRREVAG RMLETVRLAA VRGNASEILA LAGEAALSKG ADSQHASREA 150
APAAVALARS LGCTVCVSGE VDVVTDGERV VELAGGHAMM TRVTGLGCTA 200
TAFVGAFLAV NPDYFAATCH AMAVMAAAGR LAAAGVAGPG SLAVRFLDVV 250
YSLTEAEIAA GARVSA 266
Length:266
Mass (Da):26,257
Last modified:July 28, 2009 - v1
Checksum:i2807B3B4BB398CDC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010904 Genomic DNA. Translation: BAH76568.1.
RefSeqiYP_002954454.1. NC_012796.1.

Genome annotation databases

EnsemblBacteriaiBAH76568; BAH76568; DMR_30770.
GeneIDi7983131.
KEGGidma:DMR_30770.
PATRICi21752379. VBIDesMag26496_2945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP010904 Genomic DNA. Translation: BAH76568.1 .
RefSeqi YP_002954454.1. NC_012796.1.

3D structure databases

ProteinModelPortali C4XIJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 573370.DMR_30770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH76568 ; BAH76568 ; DMR_30770 .
GeneIDi 7983131.
KEGGi dma:DMR_30770.
PATRICi 21752379. VBIDesMag26496_2945.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci DMAG573370:GHJL-3114-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Desulfovibrio magneticus strain RS-1 revealed common gene clusters in magnetotactic bacteria."
    Nakazawa H., Arakaki A., Narita-Yamada S., Yashiro I., Jinno K., Aoki N., Tsuruyama A., Okamura Y., Tanikawa S., Fujita N., Takeyama H., Matsunaga T.
    Genome Res. 19:1801-1808(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700980 / DSM 13731 / RS-1.

Entry informationi

Entry nameiTHIM_DESMR
AccessioniPrimary (citable) accession number: C4XIJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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