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C4X6U4

- C4X6U4_KLEPN

UniProt

C4X6U4 - C4X6U4_KLEPN

Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciKPNE484021:GCWL-1996-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdAImported
    ORF Names:KP1_2146Imported
    OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
    Taxonomic identifieri484021 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000010106: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi484021.KP1_2146.

    Structurei

    3D structure databases

    ProteinModelPortaliC4X6U4.
    SMRiC4X6U4. Positions 1-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    KOiK00031.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4X6U4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESKVVVPAE GQKITLQNGK LNVPHNPIIP FIEGDGIGVD VTPAMLKVVD    50
    AAVEKAYKGE RKISWMEVYT GEKSTHVYGQ DVWLPAETLD LIRDYRVAIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV 150
    IFRENSEDIY AGIEWKADSA EADKVIKFLR DEMGVKKIRF PEHCGIGIKP 200
    CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR 250
    EEFGGELIDG GPWVKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA 300
    CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK 350
    VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA 400
    KLLKCSEFGD AIIANM 416
    Length:416
    Mass (Da):45,749
    Last modified:July 28, 2009 - v1
    Checksum:i01132AB90538A89A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006725 Genomic DNA. Translation: BAH62852.1.
    RefSeqiYP_002918919.1. NC_012731.1.

    Genome annotation databases

    EnsemblBacteriaiBAH62852; BAH62852; KP1_2146.
    GeneIDi7949498.
    KEGGikpu:KP1_2146.
    PATRICi20448136. VBIKlePne21779_1885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006725 Genomic DNA. Translation: BAH62852.1 .
    RefSeqi YP_002918919.1. NC_012731.1.

    3D structure databases

    ProteinModelPortali C4X6U4.
    SMRi C4X6U4. Positions 1-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484021.KP1_2146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH62852 ; BAH62852 ; KP1_2146 .
    GeneIDi 7949498.
    KEGGi kpu:KP1_2146.
    PATRICi 20448136. VBIKlePne21779_1885.

    Phylogenomic databases

    eggNOGi COG0538.
    KOi K00031.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci KPNE484021:GCWL-1996-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
      Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
      J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NTUH-K2044Imported.

    Entry informationi

    Entry nameiC4X6U4_KLEPN
    AccessioniPrimary (citable) accession number: C4X6U4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3