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C4X6U4

- C4X6U4_KLEPN

UniProt

C4X6U4 - C4X6U4_KLEPN

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icdA

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-1996-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdAImported
ORF Names:KP1_2146Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
Taxonomic identifieri484021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000010106: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi484021.KP1_2146.

Structurei

3D structure databases

ProteinModelPortaliC4X6U4.
SMRiC4X6U4. Positions 1-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
KOiK00031.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4X6U4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPAE GQKITLQNGK LNVPHNPIIP FIEGDGIGVD VTPAMLKVVD
60 70 80 90 100
AAVEKAYKGE RKISWMEVYT GEKSTHVYGQ DVWLPAETLD LIRDYRVAIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYYQGTPSP VKHPELTDMV
160 170 180 190 200
IFRENSEDIY AGIEWKADSA EADKVIKFLR DEMGVKKIRF PEHCGIGIKP
210 220 230 240 250
CSEEGTKRLV RAAIEYAITN DRDSVTLVHK GNIMKFTEGA FKDWGYQLAR
260 270 280 290 300
EEFGGELIDG GPWVKIKNPN TGKEIVVKDV IADAFLQQIL LRPAEYDVIA
310 320 330 340 350
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK
360 370 380 390 400
VNPGSIILSA EMMLRHMQWF EAADLIVKGM EGAIAAKTVT YDFERLMEGA
410
KLLKCSEFGD AIIANM
Length:416
Mass (Da):45,749
Last modified:July 28, 2009 - v1
Checksum:i01132AB90538A89A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH62852.1.
RefSeqiYP_002918919.1. NC_012731.1.

Genome annotation databases

EnsemblBacteriaiBAH62852; BAH62852; KP1_2146.
GeneIDi7949498.
KEGGikpu:KP1_2146.
PATRICi20448136. VBIKlePne21779_1885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH62852.1 .
RefSeqi YP_002918919.1. NC_012731.1.

3D structure databases

ProteinModelPortali C4X6U4.
SMRi C4X6U4. Positions 1-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484021.KP1_2146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH62852 ; BAH62852 ; KP1_2146 .
GeneIDi 7949498.
KEGGi kpu:KP1_2146.
PATRICi 20448136. VBIKlePne21779_1885.

Phylogenomic databases

eggNOGi COG0538.
KOi K00031.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci KPNE484021:GCWL-1996-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
    Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
    J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTUH-K2044Imported.

Entry informationi

Entry nameiC4X6U4_KLEPN
AccessioniPrimary (citable) accession number: C4X6U4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 1, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3