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C4X4B4 (C4X4B4_KLEPN) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL BAH61972.1
ORF Names:KP1_1182 EMBL BAH61972.1
OrganismKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044 [Complete proteome] EMBL BAH61972.1
Taxonomic identifier484021 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain145 – 348204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding175 – 23056ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3021Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3151Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3171Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C4X4B4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: B7DB86A68EE2AD01

FASTA36539,445
        10         20         30         40         50         60 
MAKMRVGIVF GGKSAEHEVS LQSAKNIVEA IDKSRFDVVL LGIDKQGLWH INDAGNYLLN 

        70         80         90        100        110        120 
AQDPARIALR PSTVTLAQIP GREAQQLINA ESGQPLAAID VIFPIVHGTL GEDGSLQGML 

       130        140        150        160        170        180 
RMANLPFVGS DVLGSAACMD KDVTKRLLRD AGLAVAPFIT LTRANRAQFS FADVEAKLGL 

       190        200        210        220        230        240 
PLFVKPANQG SSVGVSKVKN EEQYHQAVAL AFEFDHKVVV EQGIKGREIE CAVLGNDHPQ 

       250        260        270        280        290        300 
ASTCGEIVLN SEFYAYDTKY IDDQGAQVVV PAAIAPEIND KIRAIAVQAY QTLGCSGMAR 

       310        320        330        340        350        360 
VDVFLTADNE VVINEINTLP GFTNISMYPK LWQASGLDYT SLITRLIELA LERHAADRAL 


KTSMN 

« Hide

References

[1]Wu K.M., Tsai S.F.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NTUH-K2044 EMBL BAH61972.1.
[2]"Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NTUH-K2044 EMBL BAH61972.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006725 Genomic DNA. Translation: BAH61972.1.
RefSeqYP_002918039.1. NC_012731.1.

3D structure databases

ProteinModelPortalC4X4B4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING484021.KP1_1182.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH61972; BAH61972; KP1_1182.
GeneID7944897.
KEGGkpu:KP1_1182.
PATRIC20446375. VBIKlePne21779_1025.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
KOK01921.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycKPNE484021:GCWL-1098-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4X4B4_KLEPN
AccessionPrimary (citable) accession number: C4X4B4
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)