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C4X273

- C4X273_KLEPN

UniProt

C4X273 - C4X273_KLEPN

Protein

Xylose isomerase

Gene

xylA

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051UniRule annotation
    Active sitei108 – 1081UniRule annotation
    Metal bindingi236 – 2361Magnesium 1UniRule annotation
    Metal bindingi272 – 2721Magnesium 1UniRule annotation
    Metal bindingi272 – 2721Magnesium 2UniRule annotation
    Metal bindingi275 – 2751Magnesium 2UniRule annotation
    Metal bindingi300 – 3001Magnesium 1UniRule annotation
    Metal bindingi311 – 3111Magnesium 2UniRule annotation
    Metal bindingi313 – 3131Magnesium 2UniRule annotation
    Metal bindingi343 – 3431Magnesium 1UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. xylose isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-xylose metabolic process Source: UniProtKB-HAMAP
    2. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotation, Xylose metabolismUniRule annotationSAAS annotation

    Keywords - Ligandi

    MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciKPNE484021:GCWL-4896-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
    Gene namesi
    Name:xylAUniRule annotationImported
    ORF Names:KP1_5276Imported
    OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
    Taxonomic identifieri484021 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
    ProteomesiUP000010106: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi484021.KP1_5276.

    Structurei

    3D structure databases

    ProteinModelPortaliC4X273.
    SMRiC4X273. Positions 7-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the xylose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2115.
    KOiK01805.
    OrthoDBiEOG62NX4R.

    Family and domain databases

    Gene3Di3.20.20.150. 1 hit.
    HAMAPiMF_00455. Xylose_isom_A.
    InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view]
    PfamiPF01261. AP_endonuc_2. 1 hit.
    [Graphical view]
    PRINTSiPR00688. XYLOSISMRASE.
    SUPFAMiSSF51658. SSF51658. 1 hit.
    TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
    PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C4X273-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSMQTYFD QLDRVRYEGP KSTNPLAFRH YNPDELVLGK RMEDHLRFAA    50
    CYWHTFCWNG ADMFGVGSFD RPWQQPGDAL EMAKRKADVA FEFFHKLNVP 100
    YYCFHDVDVS PEGASLKEYS NNFARMVEVL AEKQQQSGVK LLWGTANCFT 150
    NPRYGAGAAT NPDPEVFSWA ATQVVTAMNA THQLGGENYV LWGGREGYET 200
    LLNTDLRQER EQIGRFMQLV VEHKHKIGFK GTLLIEPKPQ EPTKHQYDYD 250
    ASTVYGFLKQ FGLEKEIKLN IEANHATLAG HSFHHEIATA IALGLFGSVD 300
    ANRGDPQLGW DTDQFPNSVE ENALVMYEIL KAGGFTTGGL NFDAKVRRQS 350
    TDKYDLFYGH IGAMDTMALS LKVAARMIED GELDKRVARR YAGWNGELGQ 400
    QILNGQMTLS DIAQYAAQHQ LAPQHRSGQQ EQLENLVNHY LFDK 444
    Length:444
    Mass (Da):50,376
    Last modified:July 28, 2009 - v1
    Checksum:i1A43F99ED8684B5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006725 Genomic DNA. Translation: BAH65708.1.
    RefSeqiYP_002921775.1. NC_012731.1.

    Genome annotation databases

    EnsemblBacteriaiBAH65708; BAH65708; KP1_5276.
    GeneIDi7948914.
    KEGGikpu:KP1_5276.
    PATRICi20453738. VBIKlePne21779_4636.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006725 Genomic DNA. Translation: BAH65708.1 .
    RefSeqi YP_002921775.1. NC_012731.1.

    3D structure databases

    ProteinModelPortali C4X273.
    SMRi C4X273. Positions 7-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 484021.KP1_5276.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAH65708 ; BAH65708 ; KP1_5276 .
    GeneIDi 7948914.
    KEGGi kpu:KP1_5276.
    PATRICi 20453738. VBIKlePne21779_4636.

    Phylogenomic databases

    eggNOGi COG2115.
    KOi K01805.
    OrthoDBi EOG62NX4R.

    Enzyme and pathway databases

    BioCyci KPNE484021:GCWL-4896-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.150. 1 hit.
    HAMAPi MF_00455. Xylose_isom_A.
    InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
    IPR013452. Xylose_isom_bac.
    IPR001998. Xylose_isomerase.
    [Graphical view ]
    Pfami PF01261. AP_endonuc_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00688. XYLOSISMRASE.
    SUPFAMi SSF51658. SSF51658. 1 hit.
    TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
    PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
      Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
      J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NTUH-K2044Imported.

    Entry informationi

    Entry nameiC4X273_KLEPN
    AccessioniPrimary (citable) accession number: C4X273
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3