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Protein

Xylose isomerase

Gene

xylA

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051UniRule annotation
Active sitei108 – 1081UniRule annotation
Metal bindingi236 – 2361Magnesium 1UniRule annotation
Metal bindingi272 – 2721Magnesium 1UniRule annotation
Metal bindingi272 – 2721Magnesium 2UniRule annotation
Metal bindingi275 – 2751Magnesium 2UniRule annotation
Metal bindingi300 – 3001Magnesium 1UniRule annotation
Metal bindingi311 – 3111Magnesium 2UniRule annotation
Metal bindingi313 – 3131Magnesium 2UniRule annotation
Metal bindingi343 – 3431Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-4896-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
ORF Names:KP1_5276Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
Taxonomic identifieri484021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000010106: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi484021.KP1_5276.

Structurei

3D structure databases

ProteinModelPortaliC4X273.
SMRiC4X273. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
KOiK01805.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4X273-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSMQTYFD QLDRVRYEGP KSTNPLAFRH YNPDELVLGK RMEDHLRFAA
60 70 80 90 100
CYWHTFCWNG ADMFGVGSFD RPWQQPGDAL EMAKRKADVA FEFFHKLNVP
110 120 130 140 150
YYCFHDVDVS PEGASLKEYS NNFARMVEVL AEKQQQSGVK LLWGTANCFT
160 170 180 190 200
NPRYGAGAAT NPDPEVFSWA ATQVVTAMNA THQLGGENYV LWGGREGYET
210 220 230 240 250
LLNTDLRQER EQIGRFMQLV VEHKHKIGFK GTLLIEPKPQ EPTKHQYDYD
260 270 280 290 300
ASTVYGFLKQ FGLEKEIKLN IEANHATLAG HSFHHEIATA IALGLFGSVD
310 320 330 340 350
ANRGDPQLGW DTDQFPNSVE ENALVMYEIL KAGGFTTGGL NFDAKVRRQS
360 370 380 390 400
TDKYDLFYGH IGAMDTMALS LKVAARMIED GELDKRVARR YAGWNGELGQ
410 420 430 440
QILNGQMTLS DIAQYAAQHQ LAPQHRSGQQ EQLENLVNHY LFDK
Length:444
Mass (Da):50,376
Last modified:July 28, 2009 - v1
Checksum:i1A43F99ED8684B5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1.
RefSeqiYP_002921775.1. NC_012731.1.

Genome annotation databases

EnsemblBacteriaiBAH65708; BAH65708; KP1_5276.
GeneIDi7948914.
KEGGikpu:KP1_5276.
PATRICi20453738. VBIKlePne21779_4636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1.
RefSeqiYP_002921775.1. NC_012731.1.

3D structure databases

ProteinModelPortaliC4X273.
SMRiC4X273. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484021.KP1_5276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH65708; BAH65708; KP1_5276.
GeneIDi7948914.
KEGGikpu:KP1_5276.
PATRICi20453738. VBIKlePne21779_4636.

Phylogenomic databases

eggNOGiCOG2115.
KOiK01805.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-4896-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
    Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
    J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTUH-K2044Imported.

Entry informationi

Entry nameiC4X273_KLEPN
AccessioniPrimary (citable) accession number: C4X273
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: January 7, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.