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C4X273

- C4X273_KLEPN

UniProt

C4X273 - C4X273_KLEPN

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Protein

Xylose isomerase

Gene

xylA

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051UniRule annotation
Active sitei108 – 1081UniRule annotation
Metal bindingi236 – 2361Magnesium 1UniRule annotation
Metal bindingi272 – 2721Magnesium 1UniRule annotation
Metal bindingi272 – 2721Magnesium 2UniRule annotation
Metal bindingi275 – 2751Magnesium 2UniRule annotation
Metal bindingi300 – 3001Magnesium 1UniRule annotation
Metal bindingi311 – 3111Magnesium 2UniRule annotation
Metal bindingi313 – 3131Magnesium 2UniRule annotation
Metal bindingi343 – 3431Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-4896-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
ORF Names:KP1_5276Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
Taxonomic identifieri484021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000010106: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi484021.KP1_5276.

Structurei

3D structure databases

ProteinModelPortaliC4X273.
SMRiC4X273. Positions 7-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
KOiK01805.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4X273 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSMQTYFD QLDRVRYEGP KSTNPLAFRH YNPDELVLGK RMEDHLRFAA
60 70 80 90 100
CYWHTFCWNG ADMFGVGSFD RPWQQPGDAL EMAKRKADVA FEFFHKLNVP
110 120 130 140 150
YYCFHDVDVS PEGASLKEYS NNFARMVEVL AEKQQQSGVK LLWGTANCFT
160 170 180 190 200
NPRYGAGAAT NPDPEVFSWA ATQVVTAMNA THQLGGENYV LWGGREGYET
210 220 230 240 250
LLNTDLRQER EQIGRFMQLV VEHKHKIGFK GTLLIEPKPQ EPTKHQYDYD
260 270 280 290 300
ASTVYGFLKQ FGLEKEIKLN IEANHATLAG HSFHHEIATA IALGLFGSVD
310 320 330 340 350
ANRGDPQLGW DTDQFPNSVE ENALVMYEIL KAGGFTTGGL NFDAKVRRQS
360 370 380 390 400
TDKYDLFYGH IGAMDTMALS LKVAARMIED GELDKRVARR YAGWNGELGQ
410 420 430 440
QILNGQMTLS DIAQYAAQHQ LAPQHRSGQQ EQLENLVNHY LFDK
Length:444
Mass (Da):50,376
Last modified:July 28, 2009 - v1
Checksum:i1A43F99ED8684B5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1.
RefSeqiYP_002921775.1. NC_012731.1.

Genome annotation databases

EnsemblBacteriaiBAH65708; BAH65708; KP1_5276.
GeneIDi7948914.
KEGGikpu:KP1_5276.
PATRICi20453738. VBIKlePne21779_4636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1 .
RefSeqi YP_002921775.1. NC_012731.1.

3D structure databases

ProteinModelPortali C4X273.
SMRi C4X273. Positions 7-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484021.KP1_5276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH65708 ; BAH65708 ; KP1_5276 .
GeneIDi 7948914.
KEGGi kpu:KP1_5276.
PATRICi 20453738. VBIKlePne21779_4636.

Phylogenomic databases

eggNOGi COG2115.
KOi K01805.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci KPNE484021:GCWL-4896-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
    Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
    J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTUH-K2044Imported.

Entry informationi

Entry nameiC4X273_KLEPN
AccessioniPrimary (citable) accession number: C4X273
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3