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C4X273

- C4X273_KLEPN

UniProt

C4X273 - C4X273_KLEPN

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Protein
Xylose isomerase
Gene
xylA, KP1_5276
Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051 By similarityUniRule annotation
Active sitei108 – 1081 By similarityUniRule annotation
Metal bindingi236 – 2361Magnesium 1 By similarityUniRule annotation
Metal bindingi272 – 2721Magnesium 1 By similarityUniRule annotation
Metal bindingi272 – 2721Magnesium 2 By similarityUniRule annotation
Metal bindingi275 – 2751Magnesium 2 By similarityUniRule annotation
Metal bindingi300 – 3001Magnesium 1 By similarityUniRule annotation
Metal bindingi311 – 3111Magnesium 2 By similarityUniRule annotation
Metal bindingi313 – 3131Magnesium 2 By similarityUniRule annotation
Metal bindingi343 – 3431Magnesium 1 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotationSAAS annotations, Xylose metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-4896-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
ORF Names:KP1_5276Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
Taxonomic identifieri484021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000010106: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi484021.KP1_5276.

Structurei

3D structure databases

ProteinModelPortaliC4X273.
SMRiC4X273. Positions 7-443.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2115.
KOiK01805.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4X273-1 [UniParc]FASTAAdd to Basket

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MEFSMQTYFD QLDRVRYEGP KSTNPLAFRH YNPDELVLGK RMEDHLRFAA    50
CYWHTFCWNG ADMFGVGSFD RPWQQPGDAL EMAKRKADVA FEFFHKLNVP 100
YYCFHDVDVS PEGASLKEYS NNFARMVEVL AEKQQQSGVK LLWGTANCFT 150
NPRYGAGAAT NPDPEVFSWA ATQVVTAMNA THQLGGENYV LWGGREGYET 200
LLNTDLRQER EQIGRFMQLV VEHKHKIGFK GTLLIEPKPQ EPTKHQYDYD 250
ASTVYGFLKQ FGLEKEIKLN IEANHATLAG HSFHHEIATA IALGLFGSVD 300
ANRGDPQLGW DTDQFPNSVE ENALVMYEIL KAGGFTTGGL NFDAKVRRQS 350
TDKYDLFYGH IGAMDTMALS LKVAARMIED GELDKRVARR YAGWNGELGQ 400
QILNGQMTLS DIAQYAAQHQ LAPQHRSGQQ EQLENLVNHY LFDK 444
Length:444
Mass (Da):50,376
Last modified:July 28, 2009 - v1
Checksum:i1A43F99ED8684B5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1.
RefSeqiYP_002921775.1. NC_012731.1.

Genome annotation databases

EnsemblBacteriaiBAH65708; BAH65708; KP1_5276.
GeneIDi7948914.
KEGGikpu:KP1_5276.
PATRICi20453738. VBIKlePne21779_4636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006725 Genomic DNA. Translation: BAH65708.1 .
RefSeqi YP_002921775.1. NC_012731.1.

3D structure databases

ProteinModelPortali C4X273.
SMRi C4X273. Positions 7-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 484021.KP1_5276.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAH65708 ; BAH65708 ; KP1_5276 .
GeneIDi 7948914.
KEGGi kpu:KP1_5276.
PATRICi 20453738. VBIKlePne21779_4636.

Phylogenomic databases

eggNOGi COG2115.
KOi K01805.
OrthoDBi EOG62NX4R.

Enzyme and pathway databases

BioCyci KPNE484021:GCWL-4896-MONOMER.

Family and domain databases

Gene3Di 3.20.20.150. 1 hit.
HAMAPi MF_00455. Xylose_isom_A.
InterProi IPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view ]
Pfami PF01261. AP_endonuc_2. 1 hit.
[Graphical view ]
PRINTSi PR00688. XYLOSISMRASE.
SUPFAMi SSF51658. SSF51658. 1 hit.
TIGRFAMsi TIGR02630. xylose_isom_A. 1 hit.
PROSITEi PS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
    Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
    J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTUH-K2044Imported.

Entry informationi

Entry nameiC4X273_KLEPN
AccessioniPrimary (citable) accession number: C4X273
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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