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Protein
Submitted name:

Bifunctional aspartate kinase II/homoserine dehydrogenase II

Gene

metL

Organism
Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. aspartate kinase activity Source: InterPro
  2. homoserine dehydrogenase activity Source: InterPro
  3. NADP binding Source: InterPro

GO - Biological processi

  1. aspartate family amino acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-90-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional aspartate kinase II/homoserine dehydrogenase IIImported
Gene namesi
Name:metLImported
ORF Names:KP1_0096Imported
OrganismiKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044Imported
Taxonomic identifieri484021 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella
ProteomesiUP000010106: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi484021.KP1_0096.

Structurei

3D structure databases

ProteinModelPortaliC4WZM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0527.
KOiK12525.
OrthoDBiEOG6M0T34.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00657. asp_kinases. 1 hit.
PROSITEiPS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4WZM0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSVIAQAGAK GRQLHKFGGS SLADAKCYLR VAGIMKEYSQ AGDMMVVSAA
60 70 80 90 100
GSTTNQLISW LKLSQSDRLA AHQVQQSLRR YHTELIGGLL EPAAADTLIA
110 120 130 140 150
AFIHDLERLA GLLDGGVSEA VYAEVVGHGE VWSARLMAAV LNQLGMEAAW
160 170 180 190 200
LDARAFLRAE RAAQPQVDEG LSYPLLQQLM AQHPNKRLVV TGFISRNQAG
210 220 230 240 250
ETVLLGRNGS DYSATQIGAL AGASRVTIWS DVAGVYSADP RKVKDACLLP
260 270 280 290 300
LLRLDEASEL ARLAAPVLHA RTLQPVSASD IDLQLRCSYT PEQGSTRIER
310 320 330 340 350
VLASGTGARI VTSHDDVCLV EFQVPAGHDF KLAHKELDAL LKRAQLRPLA
360 370 380 390 400
VGVHADRKLL QFCYTSEVAD SALKLLDEAG LPGELRLRQK LALVAMVGAG
410 420 430 440 450
VTRNPLHCHR FWQQLKGQPV EFTWQSEEGI SLVAVLRAGP TESLIQGLHQ
460 470 480 490 500
SLFRAEKRIG LMLFGKGNIG SRWLELFARE QTTLSARTGF EFILAGVVDS
510 520 530 540 550
KRSLLNYDGL DASRALAFFN DEAVEQDEES LFLWMRAHPY DDLVVLDVTA
560 570 580 590 600
SEQLADQYLD FASHGFHVIS ANKLAGASSS DKYRQIHDAF EKTGRHWLYN
610 620 630 640 650
ATVGAGLPVN HTVRDLIDSG DTILGLSGIF SGTLSWLFLQ FDGTVPFTDL
660 670 680 690 700
VDQAWQQGLT EPDPRVDLSG KDVMRKLVIL AREAGYDIEP DQVRVESLVP
710 720 730 740 750
AHCEEGSVDH FFENGEELNE QMLQRLEAAR EMGLVLRYVA RFDANGKARV
760 770 780 790 800
GVEAVREEHP LAALLPCDNV FAIESRWYRD NPLVIRGPGA GRDVTAGAIQ
810
SDINRLAQLL
Length:810
Mass (Da):88,714
Last modified:July 28, 2009 - v1
Checksum:iC1043E9F6A738F9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006725 Genomic DNA. Translation: BAH61009.1.
RefSeqiYP_002917076.1. NC_012731.1.

Genome annotation databases

EnsemblBacteriaiBAH61009; BAH61009; KP1_0096.
GeneIDi7947865.
KEGGikpu:KP1_0096.
PATRICi20444409. VBIKlePne21779_0086.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006725 Genomic DNA. Translation: BAH61009.1.
RefSeqiYP_002917076.1. NC_012731.1.

3D structure databases

ProteinModelPortaliC4WZM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi484021.KP1_0096.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAH61009; BAH61009; KP1_0096.
GeneIDi7947865.
KEGGikpu:KP1_0096.
PATRICi20444409. VBIKlePne21779_0086.

Phylogenomic databases

eggNOGiCOG0527.
KOiK12525.
OrthoDBiEOG6M0T34.

Enzyme and pathway databases

BioCyciKPNE484021:GCWL-90-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 2 hits.
3.40.50.720. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR005106. Asp/hSer_DH_NAD-bd.
IPR001341. Asp_kinase_dom.
IPR018042. Aspartate_kinase_CS.
IPR011147. Bifunc_aspartokin/hSer_DH.
IPR001342. HDH_cat.
IPR019811. HDH_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
PF00742. Homoserine_dh. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000727. ThrA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00657. asp_kinases. 1 hit.
PROSITEiPS00324. ASPARTOKINASE. 1 hit.
PS01042. HOMOSER_DHGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
    Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
    J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NTUH-K2044Imported.

Entry informationi

Entry nameiC4WZM0_KLEPN
AccessioniPrimary (citable) accession number: C4WZM0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: January 7, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.