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C4WZK9 (C4WZK9_KLEPN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphofructokinase HAMAP-Rule MF_00339
Short name=Phosphofructokinase HAMAP-Rule MF_00339
EC=2.7.1.11 HAMAP-Rule MF_00339
Alternative name(s):
Phosphohexokinase HAMAP-Rule MF_00339
Gene names
Name:pfkA HAMAP-Rule MF_00339 EMBL BAH60998.1
ORF Names:KP1_0082 EMBL BAH60998.1
OrganismKlebsiella pneumoniae subsp. pneumoniae NTUH-K2044 EMBL BAH60998.1
Taxonomic identifier484021 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella ›

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP-Rule MF_00339 SAAS SAAS000023

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP-Rule MF_00339 SAAS SAAS000023

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00339 SAAS SAAS000023.

Sequence similarities

Belongs to the phosphofructokinase family. HAMAP-Rule MF_00339

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding22 – 265ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding155 – 1595ATP By similarity HAMAP-Rule MF_00339
Nucleotide binding172 – 18817ATP By similarity HAMAP-Rule MF_00339

Sites

Active site1281Proton acceptor By similarity HAMAP-Rule MF_00339
Metal binding1861Magnesium; via carbonyl oxygen By similarity HAMAP-Rule MF_00339
Metal binding1881Magnesium By similarity HAMAP-Rule MF_00339
Binding site1631Substrate By similarity HAMAP-Rule MF_00339
Binding site2441Substrate By similarity HAMAP-Rule MF_00339
Binding site2501Substrate By similarity HAMAP-Rule MF_00339
Binding site2531Substrate By similarity HAMAP-Rule MF_00339

Sequences

Sequence LengthMass (Da)Tools
C4WZK9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 07544D8598DF1604

FASTA32034,984
        10         20         30         40         50         60 
MIKKIGVLTS GGDAPGMNAA IRGVVRAALT EGLEVFGIYD GYLGLYEDRM VQLDRYSVSD 

        70         80         90        100        110        120 
MINRGGTFLG SARFPEFREE HIRAVAIENM KKRGLDALVV IGGDGSYMGA MRLTEMGFPC 

       130        140        150        160        170        180 
IGLPGTIDND IKGTDYTIGF FTALSTVVEA IDRLRDTSSS HQRISVVEVM GRYCGDLTLA 

       190        200        210        220        230        240 
AAIAGGCEFI MVPEVEYTRD DLVAEIKAGI AKGKKHAIVA ITEHMCDVDE LASYIEKETG 

       250        260        270        280        290        300 
RETRATVLGH IQRGGSPVPY DRILASRMGA YAIELLLQGH GGRCVGIQNE KLVHHDIIDA 

       310        320 
IENMKRPFKN DWLDCAKKLY

« Hide

References

[1]Wu K.M., Tsai S.F.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NTUH-K2044 EMBL BAH60998.1.
[2]"Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis."
Wu K.-M., Li L.-H., Yan J.-J., Tsao N., Liao T.-L., Tsai H.-C., Fung C.-P., Chen H.-J., Liu Y.-M., Wang J.-T., Fang C.-T., Chang S.-C., Shu H.-Y., Liu T.-T., Chen Y.-T., Shiau Y.-R., Lauderdale T.-L., Su I.-J., Kirby R., Tsai S.-F.
J. Bacteriol. 191:4492-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NTUH-K2044 EMBL BAH60998.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006725 Genomic DNA. Translation: BAH60998.1.
RefSeqYP_002917065.1. NC_012731.1.

3D structure databases

ProteinModelPortalC4WZK9.
SMRC4WZK9. Positions 1-320.
ModBaseSearch...

Protein-protein interaction databases

STRING484021.KP1_0082.
C4WZK9.

Proteomic databases

PRIDEC4WZK9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAH60998; BAH60998; KP1_0082.
GeneID7947355.
KEGGkpu:KP1_0082.
PATRIC20444387. VBIKlePne21779_0075.

Phylogenomic databases

eggNOGCOG0205.
KOK00850.
ProtClustDBPRK03202.

Enzyme and pathway databases

UniPathwayUPA00109; UER00182.

Family and domain databases

HAMAPMF_00339. Phosphofructokinase.
InterProIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamPF00365. PFK. 1 hit.
[Graphical view]
PIRSFPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSPR00476. PHFRCTKINASE.
SUPFAMSSF53784. Ppfruckinase. 1 hit.
TIGRFAMsTIGR02482. PFKA_ATP. 1 hit.
PROSITEPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC4WZK9_KLEPN
AccessionPrimary (citable) accession number: C4WZK9
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info