Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

mRNA cap guanine-N7 methyltransferase

Gene

ACYPI001020

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45S-adenosyl-L-methionineUniRule annotation1
Binding sitei72S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei95S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferaseUniRule annotation, RNA-bindingUniRule annotation, Transferase
Biological processmRNA cappingUniRule annotation, mRNA processing
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA cap guanine-N7 methyltransferaseUniRule annotation (EC:2.1.1.56UniRule annotation)
Gene namesi
Name:ACYPI001020Imported
Synonyms:LOC100159670Imported
OrganismiAcyrthosiphon pisum (Pea aphid)Imported
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
Proteomesi
  • UP000007819 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7029.ACYPI001020-PA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 339MRNA cap 0 methyltransferaseInterPro annotationAdd BLAST339

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 128S-adenosyl-L-methionine bindingUniRule annotation2
Regioni150 – 152S-adenosyl-L-methionine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1975. Eukaryota.
ENOG410Y7HG. LUCA.
HOGENOMiHOG000242614.
KOiK00565.

Family and domain databases

InterProiView protein in InterPro
IPR016899. mRNA_G-N7_MeTrfase.
IPR004971. mRNA_G-N7_MeTrfase_dom.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF03291. Pox_MCEL. 1 hit.
PIRSFiPIRSF028762. ABD1. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51562. RNA_CAP0_MT. 1 hit.

Sequencei

Sequence statusi: Complete.

C4WXH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVTKPQEL LSATIARHYD HGENNLSARN ASRILYLRNF NNWVKSTLIQ
60 70 80 90 100
EAVTMLRDSR IHDGKMHVLD FACGKGGDLN KWRNSSCMEY LVAVDISPGS
110 120 130 140 150
IGNCHSRYKE MKARNRYLFD AEFIVADCTR VNINTLFKDS CMKLHLVSCQ
160 170 180 190 200
FAFHYCFESI QQAECMLKNV SENLVSGGIF IGTIPNAREI VRRQKECGEK
210 220 230 240 250
QFGNSIYNIE FMCNIDKPFP IFGAKYNFHL EGVVDCPEFL VYFPALEKLA
260 270 280 290 300
KSYGLELKMK MTFAEYFEKH SNLDINFLSR ITALEVYPPR EGVELMGTEE
310 320 330
DYDKAKQFLN ENKQESVGTL SKSEWEVATL YMVFMFQKM
Length:339
Mass (Da):39,094
Last modified:July 28, 2009 - v1
Checksum:iBA52F6D91337BF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02040229 Genomic DNA. No translation available.
AK342640 mRNA. Translation: BAH72595.1.
RefSeqiNP_001233056.1. NM_001246127.1.
XP_008181788.1. XM_008183566.2.
UniGeneiAps.104717.
Aps.1450.
Aps.32952.

Genome annotation databases

EnsemblMetazoaiACYPI001020-RA; ACYPI001020-PA; ACYPI001020.
GeneIDi100159670.
KEGGiapi:100159670.

Entry informationi

Entry nameiC4WXH5_ACYPI
AccessioniPrimary (citable) accession number: C4WXH5
Secondary accession number(s): J9JLE6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: September 27, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported