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Protein

Superoxide dismutase [Cu-Zn]

Gene

ACYPI007471

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:ACYPI007471Imported
OrganismiAcyrthosiphon pisum (Pea aphid)
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidiformesAphidoideaAphididaeMacrosiphiniAcyrthosiphon
ProteomesiUP000007819 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7029.ACYPI007471-PA.

Structurei

3D structure databases

ProteinModelPortaliC4WRV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000263447.
InParanoidiC4WRV2.
KOiK04565.
OMAiWITQNSE.
OrthoDBiEOG776SR4.
PhylomeDBiC4WRV2.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C4WRV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVCVLNG EDVKGTIFFS QPDDKSPVEI TGELTGLSKG RHGFHIHEFG
60 70 80 90 100
DNTNGCMSSG PHFNPFGKTH GAPNDDVRHV GDLGNIEAPG SSVTKIQFND
110 120 130 140 150
PIISLTGPLN IIGRTLVVHA DQDDLGKGGH ELSATTGNAG ARIACGVIGI

TK
Length:152
Mass (Da):15,840
Last modified:July 28, 2009 - v1
Checksum:iC0AE91BC453BBF18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02023801 Genomic DNA. No translation available.
AK339927 mRNA. Translation: BAH70622.1.
RefSeqiNP_001156243.1. NM_001162771.1.
UniGeneiAps.106342.
Aps.309.
Aps.41409.

Genome annotation databases

EnsemblMetazoaiACYPI007471-RA; ACYPI007471-PA; ACYPI007471.
GeneIDi100166614.
KEGGiapi:100166614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02023801 Genomic DNA. No translation available.
AK339927 mRNA. Translation: BAH70622.1.
RefSeqiNP_001156243.1. NM_001162771.1.
UniGeneiAps.106342.
Aps.309.
Aps.41409.

3D structure databases

ProteinModelPortaliC4WRV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7029.ACYPI007471-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiACYPI007471-RA; ACYPI007471-PA; ACYPI007471.
GeneIDi100166614.
KEGGiapi:100166614.

Phylogenomic databases

HOGENOMiHOG000263447.
InParanoidiC4WRV2.
KOiK04565.
OMAiWITQNSE.
OrthoDBiEOG776SR4.
PhylomeDBiC4WRV2.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
PRINTSiPR00068. CUZNDISMTASE.
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00087. SOD_CU_ZN_1. 1 hit.
PS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A full-length cDNA resource of the pea aphid, Acyrthosiphon pisum."
    Shigenobu S., Nakabachi A., Richards S.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LSR1Imported.
    Tissue: Whole bodyImported.
  2. Jiang H., Abraham K., Ali S., Alsbrooks S.L., Anim B.N., Anosike U.S., Attaway T., Bandaranaike D.P., Battles P.K., Bell S.N., Bell A.V., Beltran B., Bickham C., Bustamante Y., Caleb T., Canada A., Cardenas V., Carter K.
    , Chacko J., Chandrabose M.N., Chavez D., Chavez A., Chen L., Chu H.-S., Claassen K.J., Cockrell R., Collins M., Cooper J.A., Cree A., Curry S.M., Da Y., Dao M.D., Das B., Davila M.-L., Davy-Carroll L., Denson S., Dinh H., Ebong V.E., Edwards J.R., Egan A., El-Daye J., Escobedo L., Fernandez S., Fernando P.R., Flagg N., Forbes L.D., Fowler R.G., Fu Q., Gabisi R.A., Ganer J., Garbino Pronczuk A., Garcia R.M., Garner T., Garrett T.E., Gonzalez D.A., Hamid H., Hawkins E.S., Hirani K., Hogues M.E., Hollins B., Hsiao C.-H., Jabil R., James M.L., Jhangiani S.N., Johnson B., Johnson Q., Joshi V., Kalu J.B., Kam C., Kashfia A., Keebler J., Kisamo H., Kovar C.L., Lago L.A., Lai C.-Y., Laidlaw J., Lara F., Le T.-K., Lee S.L., Legall F.H., Lemon S.J., Lewis L.R., Li B., Liu Y., Liu Y.-S., Lopez J., Lozado R.J., Lu J., Madu R.C., Maheshwari M., Maheshwari R., Malloy K., Martinez E., Mathew T., Mercado I.C., Mercado C., Meyer B., Montgomery K., Morgan M.B., Munidasa M., Nazareth L.V., Nelson J., Ng B.M., Nguyen N.B., Nguyen P.Q., Nguyen T., Obregon M., Okwuonu G.O., Onwere C.G., Orozco G., Parra A., Patel S., Patil S., Perez A., Perez Y., Pham C., Primus E.L., Pu L.-L., Puazo M., Qin X., Quiroz J.B., Reese J., Richards S., Rives C.M., Robberts R., Ruiz S.J., Ruiz M.J., Santibanez J., Schneider B.W., Sisson I., Smith M., Sodergren E., Song X.-Z., Song B.B., Summersgill H., Thelus R., Thornton R.D., Trejos Z.Y., Usmani K., Vattathil S., Villasana D., Walker D.L., Wang S., Wang K., White C.S., Williams A.C., Williamson J., Wilson K., Woghiren I.O., Woodworth J.R., Worley K.C., Wright R.A., Wu W., Young L., Zhang L., Zhang J., Zhu Y., Muzny D.M., Weinstock G., Gibbs R.A.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. EnsemblMetazoa
    Submitted (FEB-2015) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiC4WRV2_ACYPI
AccessioniPrimary (citable) accession number: C4WRV2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.